Functional and structural outcomes of ILM peeling in uncomplicated macula-off RRD using microperimetry & en-face OCT.

Eissa, MGAM ; Abdelhakim, MASE ; et al.

In: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Jg. 256 (2018-02-01), Heft 2, S. 249-257

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Purpose: To investigate functional and structural outcomes of internal limiting membrane (ILM) peeling during primary vitrectomy for uncomplicated macula-off rhegmatogenous retinal detachment (RRD).

Methods: In this prospective interventional randomized comparative study, 43 eyes (43 patients) were randomly divided into group A (20), and group B (23), with and without ILM peeling respectively. Patients were evaluated clinically, and by spectral-domain optical coherence tomography (SD-OCT) and microperimetry (MP) following silicone oil removal. Main outcome measures were functional-MP (mean and foveal retinal sensitivity; MRS, FRS) and best-corrected visual acuity (BCVA)-and anatomical-en-face image analysis (retinal dimples), and SD-OCT changes [epiretinal membrane (ERM), subretinal fluid (SRF), ellipsoid zone disruption, central subfoveal thickness (CSFT), and foveal contour].

Results: All eyes achieved complete postoperative attachment with mean BCVA 1.0 ± 0.4 logMAR (6/60) in group A, and 0.4 ± 0.4 logMAR (6/15) in group B (p < 0.001). MRS and FRS were significantly higher in group B (p = 0.037 and 0.036 respectively). En-face OCT showed retinal dimples in all patients in group A (29.17 ± 7.67 dimples), compared to none in group B (p = 0.007). ERM did not develop in any eye in group A, while it developed in 17.4% of eyes in group B (p = 0.05).

Conclusion: Although ILM peeling prevented ERM, it resulted in poorer visual outcome in these uncomplicated RRD cases, and might be better reserved only for complicated cases.

Titel:	Functional and structural outcomes of ILM peeling in uncomplicated macula-off RRD using microperimetry & en-face OCT.
Autor/in / Beteiligte Person:	Eissa, MGAM ; Abdelhakim, MASE ; Macky, TA ; Khafagy, MM ; Mortada, HA
Link:	View record at Springer (Volltext)
Zeitschrift:	Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Jg. 256 (2018-02-01), Heft 2, S. 249-257
Veröffentlichung:	Berlin ; New York : Springer-Verlag, c1982-, 2018
Medientyp:	academicJournal
ISSN:	1435-702X (electronic)
DOI:	10.1007/s00417-017-3875-7
Schlagwort:	Adolescent Adult Aged Basement Membrane pathology Female Follow-Up Studies Humans Male Middle Aged Postoperative Period Prospective Studies Retinal Detachment diagnosis Retinal Detachment physiopathology Tomography, Optical Coherence Treatment Outcome Young Adult Basement Membrane surgery Fovea Centralis pathology Retinal Detachment surgery Visual Acuity Visual Field Tests methods Visual Fields Vitrectomy methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial Language: English [Graefes Arch Clin Exp Ophthalmol] 2018 Feb; Vol. 256 (2), pp. 249-257. <i>Date of Electronic Publication: </i>2018 Jan 03. MeSH Terms: Visual Acuity* ; Visual Fields* ; Basement Membrane / surgery ; Fovea Centralis / pathology ; Retinal Detachment / surgery ; Visual Field Tests / methods ; Vitrectomy / *methods ; Adolescent ; Adult ; Aged ; Basement Membrane / pathology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Postoperative Period ; Prospective Studies ; Retinal Detachment / diagnosis ; Retinal Detachment / physiopathology ; Tomography, Optical Coherence ; Treatment Outcome ; Young Adult References: J Ophthalmol. 2016;2016:7030791. (PMID: 27088008) ; Retina. 2012 Oct;32(9):1719-26. (PMID: 23007669) ; Retina. 2014 Apr;34(4):655-63. (PMID: 24670998) ; Ophthalmologica. 2014;232(3):170-8. (PMID: 25323920) ; Retina. 2015 Mar;35(3):498-507. (PMID: 25158943) ; Retina. 2012 Nov-Dec;32(10):2070-6. (PMID: 22842490) ; Retina. 2012 May;32(5):877-91. (PMID: 22105502) ; Int Ophthalmol. 2014 Apr;34(2):437-46. (PMID: 23864285) ; Retina. 2017 Feb 23;:null. (PMID: 28234805) ; Cesk Slov Oftalmol. 2014 Jun;70(3):98-101. (PMID: 25032795) ; Trans Am Ophthalmol Soc. 1982;80:580-656. (PMID: 6763804) ; Invest Ophthalmol Vis Sci. 2005 Mar;46(3):1000-9. (PMID: 15728558) ; Retina. 2015 May;35(5):880-5. (PMID: 25545479) ; Vis Neurosci. 2001 Mar-Apr;18(2):299-317. (PMID: 11417804) ; Retina. 2012 Feb;32(2):226-31. (PMID: 21878849) ; Ophthalmology. 2004 Feb;111(2):238-43. (PMID: 15019369) ; Am J Ophthalmol. 2001 Sep;132(3):363-8. (PMID: 11530049) ; Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1895-902. (PMID: 19151392) ; Invest Ophthalmol Vis Sci. 2011 Oct 21;52(11):8349-55. (PMID: 21862645) ; Am J Ophthalmol. 2014 Oct;158(4):762-768.e1. (PMID: 24997234) ; Graefes Arch Clin Exp Ophthalmol. 2009 May;247(5):619-23. (PMID: 19107502) ; Acta Ophthalmol. 2012 Dec;90(8):733-7. (PMID: 21914150) ; Retina. 2010 Jun;30(6):881-6. (PMID: 20182404) ; Ophthalmologica. 2016;235(1):10-7. (PMID: 26731764) ; Am J Ophthalmol. 2016 Nov;171:1-10. (PMID: 27544480) ; Br J Ophthalmol. 2012 Dec;96(12):1513-6. (PMID: 23077227) Contributed Indexing: Keywords: En-face OCT; Epiretinal membrane; Internal limiting membrane; Microperimetery; Primary vitrectomy; Uncomplicated rhegmatogenous RD Entry Date(s): Date Created: 20180105 Date Completed: 20180214 Latest Revision: 20181113 Update Code: 20231215

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