The effect of 12-month dehydroepiandrosterone supplementation on the menstrual pattern, ovarian reserve markers, and safety profile in women with premature ovarian insufficiency.

Wong, QHY ; Yeung, TWY ; et al.

In: Journal of assisted reproduction and genetics, Jg. 35 (2018-05-01), Heft 5, S. 857-862

Online academicJournal

Zugriff:

Purpose: To evaluate the effect of 12-month DHEA supplementation on menstrual pattern and ovarian reserve markers in women with premature ovarian insufficiency (POI) METHODS: This is a prospective observational study. Women with POI were given DHEA supplements (25 mg three times daily) for 12 months. Sonographic assessment for ovarian volume and antral follicle count (AFC) and serum measurement for anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), estradiol, testosterone, liver function, and hemoglobin level were performed at baseline and monthly for 13 months after the supplementation. Menstrual pattern, ovarian reserve markers, and side-effects were recorded.

Results: Between August 2011 and July 2014, 38 women with POI were recruited and 31 completed the study. The median age of women was 36 years, and the median baseline FSH and AMH concentrations were 82.2 IU/L and 0.01 ng/ml, respectively. No women had resumption of regular menstruation after DHEA supplementation. AMH, FSH, and AFC did not change significantly. No serious side effects were reported.

Conclusions: Our results do not support any significant improvement in ovarian function by 12-month DHEA supplementation in women with POI.

Titel:	The effect of 12-month dehydroepiandrosterone supplementation on the menstrual pattern, ovarian reserve markers, and safety profile in women with premature ovarian insufficiency.
Autor/in / Beteiligte Person:	Wong, QHY ; Yeung, TWY ; Yung, SSF ; Ko, JKY ; Li, HWR ; Ng, EHY
Link:	View record at Springer (Volltext)
Zeitschrift:	Journal of assisted reproduction and genetics, Jg. 35 (2018-05-01), Heft 5, S. 857-862
Veröffentlichung:	<2004- >: Amsterdam : Springer ; <i>Original Publication</i>: New York : Plenum Press, c1992-, 2018
Medientyp:	academicJournal
ISSN:	1573-7330 (electronic)
DOI:	10.1007/s10815-018-1152-2
Schlagwort:	Adult Anti-Mullerian Hormone blood Dehydroepiandrosterone adverse effects Estradiol blood Female Follicle Stimulating Hormone blood Humans Prospective Studies Testosterone blood Biomarkers blood Dehydroepiandrosterone therapeutic use Menstrual Cycle drug effects Ovarian Reserve drug effects Primary Ovarian Insufficiency drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Observational Study Language: English [J Assist Reprod Genet] 2018 May; Vol. 35 (5), pp. 857-862. <i>Date of Electronic Publication: </i>2018 Mar 09. MeSH Terms: Biomarkers / blood ; Dehydroepiandrosterone / therapeutic use ; Menstrual Cycle / drug effects ; Ovarian Reserve / drug effects ; Primary Ovarian Insufficiency / *drug therapy ; Adult ; Anti-Mullerian Hormone / blood ; Dehydroepiandrosterone / adverse effects ; Estradiol / blood ; Female ; Follicle Stimulating Hormone / blood ; Humans ; Prospective Studies ; Testosterone / blood References: Hum Reprod. 1986 Feb;1(2):81-7. (PMID: 3558758) ; Results Probl Cell Differ. 2016;58:167-90. (PMID: 27300179) ; Hum Reprod. 2000 Oct;15(10):2129-32. (PMID: 11006185) ; Maturitas. 2010 Jun;66(2):172-9. (PMID: 20089375) ; Fertil Steril. 2009 Feb;91(2):644-6. (PMID: 18321501) ; Hum Reprod. 2014 Jan;29(1):146-54. (PMID: 24256992) ; J Clin Endocrinol Metab. 2013 Jan;98(1):380-8. (PMID: 23144466) ; J Clin Invest. 1998 Jun 15;101(12):2622-9. (PMID: 9637695) ; Maturitas. 2009 Jul 20;63(3):240-5. (PMID: 19410392) ; Fertil Steril. 2014 Jul;102(1):108-115.e1. (PMID: 24796766) ; J Gynecol Obstet Hum Reprod. 2017 Jan;46(1):1-7. (PMID: 28403950) ; J Clin Endocrinol Metab. 2011 Jun;96(6):1642-53. (PMID: 21411558) ; Ann N Y Acad Sci. 2000;900:393-402. (PMID: 10818427) ; Curr Opin Obstet Gynecol. 2006 Aug;18(4):418-26. (PMID: 16794423) ; Fertil Steril. 2005 Sep;84(3):756. (PMID: 16169414) ; Hum Reprod. 2016 May;31(5):926-37. (PMID: 27008889) ; Fertil Steril. 2009 Mar;91(3):931.e1-2. (PMID: 18922519) ; J Clin Endocrinol Metab. 1994 Nov;79(5):1470-5. (PMID: 7962345) ; J Clin Endocrinol Metab. 2000 Sep;85(9):3208-17. (PMID: 10999810) ; Curr Opin Obstet Gynecol. 2009 Aug;21(4):306-8. (PMID: 19610174) ; Hum Reprod Update. 1999 Sep-Oct;5(5):483-92. (PMID: 10582785) Contributed Indexing: Keywords: Anti-Mullerian hormone; Antral follicle count; Dehydroepiandrosterone; Follicle-stimulating hormone; Premature ovarian insufficiency Substance Nomenclature: 0 (Biomarkers) ; 3XMK78S47O (Testosterone) ; 459AG36T1B (Dehydroepiandrosterone) ; 4TI98Z838E (Estradiol) ; 80497-65-0 (Anti-Mullerian Hormone) ; 9002-68-0 (Follicle Stimulating Hormone) Entry Date(s): Date Created: 20180310 Date Completed: 20181004 Latest Revision: 20190501 Update Code: 20240513 PubMed Central ID: PMC5984890

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