Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro.

Joëls, M ; Shinnick-Gallagher, P ; et al.

In: Brain research, Jg. 417 (1987-08-04), Heft 1, S. 99-107

academicJournal

In this study we have tested the effect of serotonin (5-HT) and serotonin-analogues on passive membrane properties of septal neurons in a rat brain slice. Superfusion with 5-HT hyperpolarized the membrane potential and decreased the membrane resistance of lateral septal neurons in a concentration dependent manner. The lowest effective concentration was 1 microM while maximal effects were observed with 30 microM. Hyperpolarizing responses to 5-HT persisted in the presence of haloperidol, phentolamine or ritanserin. The 5-HTIa agonist 8-hydroxy-2-[n-dipropylamino]tetralin (8OHDPAT) hyperpolarized septal neurons like 5-HT though the agonist was active at a lower concentration than 5-HT and induced longer-lasting effects. Two other 5-HT1a analogues, TVX Q 7821 and buspirone, could also mimick the effect of 5-HT. The 5-HT1b agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP) did not appreciably affect the membrane potential or resistance of septal neurons. The present results are consistent with data from binding studies and suggest that the effect of 5-HT on lateral septal neurons is at least partly mediated through 5-HT1a-like receptors.

Titel:	Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro.
Autor/in / Beteiligte Person:	Joëls, M ; Shinnick-Gallagher, P ; Gallagher, JP
Link:	E-Journal im Bestand der UB Hagen?
Zeitschrift:	Brain research, Jg. 417 (1987-08-04), Heft 1, S. 99-107
Veröffentlichung:	Amsterdam Elsevier/North-Holland Biomedical Press., 1987
Medientyp:	academicJournal
ISSN:	0006-8993 (print)
DOI:	10.1016/0006-8993(87)90183-1
Schlagwort:	8-Hydroxy-2-(di-n-propylamino)tetralin Animals Buspirone Cell Membrane drug effects Electric Conductivity Fenfluramine analogs & derivatives Fenfluramine pharmacology Male Membrane Potentials drug effects Pyrimidines pharmacology Rats Rats, Inbred Strains Receptors, Serotonin drug effects Tetrahydronaphthalenes pharmacology Septum Pellucidum drug effects Serotonin pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Language: English [Brain Res] 1987 Aug 04; Vol. 417 (1), pp. 99-107. MeSH Terms: Septum Pellucidum / drug effects ; Serotonin / pharmacology ; 8-Hydroxy-2-(di-n-propylamino)tetralin ; Animals ; Buspirone ; Cell Membrane / drug effects ; Electric Conductivity ; Fenfluramine / analogs & derivatives ; Fenfluramine / pharmacology ; Male ; Membrane Potentials / drug effects ; Pyrimidines / pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Serotonin / drug effects ; Tetrahydronaphthalenes / pharmacology Grant Information: MH/39163 United States MH NIMH NIH HHS Contributed Indexing: Indexing Agency: NASA Local ID #: 87300833. Substance Nomenclature: 0 (Pyrimidines) ; 0 (Receptors, Serotonin) ; 0 (Tetrahydronaphthalenes) ; 2DS058H2CF (Fenfluramine) ; 333DO1RDJY (Serotonin) ; 621-45-4 (1-(3-trifluoromethylphenyl)-2-propanol) ; 6J9B11MN0K (ipsapirone) ; 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin) ; TK65WKS8HL (Buspirone) Entry Date(s): Date Created: 19870804 Date Completed: 19871013 Latest Revision: 20190614 Update Code: 20240513

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