Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation.

Olatunji, OJ ; Chen, H ; et al.

In: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jg. 102 (2018-06-01), S. 1145-1151

academicJournal

Diabetic nephropathy is one of the most serious and most frequently encountered diabetic complication, accounting for the highest cause of end-stage renal disease. This present study was aimed at exploring the protective/attenuative effect of Lycium chinense leaf extract (MELC) on streptozotocin induced diabetic nephropathy in experimental Sprague Dawley rats. The oral administration of diabetic rats with MELC markedly ameliorated renal dysfunction as observed in the signiﬁcant reduction in the serum levels of creatinine, blood urea nitrogen (BUN), albumin and TGF-β1 as compared to the untreated diabetic control rats. In addition, the elevated levels of renal oxidative stress markers and pro-inflammatory parameters (GSH, SOD, CAT, MDA, TNF-α, IL-6 and IL-1β) were significantly reduced in MELC treated diabetic rats. The results obtained in this study suggests that L. chinense leaf might have the potential as possible pharmacological agent against diabetic nephropathy by suppressing renal oxidative stress and inﬂammation.

Titel:	Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation.
Autor/in / Beteiligte Person:	Olatunji, OJ ; Chen, H ; Zhou, Y
Zeitschrift:	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jg. 102 (2018-06-01), S. 1145-1151
Veröffentlichung:	Paris : Editions Scientifiques Elsevier ; <i>Original Publication</i>: New York, N.Y. : Masson Pub. USA, Inc., c1982-, 2018
Medientyp:	academicJournal
ISSN:	1950-6007 (electronic)
DOI:	10.1016/j.biopha.2018.03.037
Schlagwort:	Animals Antioxidants metabolism Biomarkers blood Biomarkers urine Diabetes Mellitus, Experimental blood Diabetes Mellitus, Experimental complications Diabetes Mellitus, Experimental drug therapy Diabetes Mellitus, Experimental pathology Diabetic Nephropathies blood Diabetic Nephropathies complications Diabetic Nephropathies pathology Hyperglycemia complications Hyperglycemia pathology Hypertrophy Inflammation complications Inflammation pathology Kidney drug effects Male Plant Extracts pharmacology Rats, Sprague-Dawley Streptozocin Transforming Growth Factor beta1 metabolism Diabetic Nephropathies drug therapy Hyperglycemia drug therapy Inflammation drug therapy Kidney pathology Lycium chemistry Oxidative Stress drug effects Plant Extracts therapeutic use Plant Leaves chemistry
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Biomed Pharmacother] 2018 Jun; Vol. 102, pp. 1145-1151. <i>Date of Electronic Publication: </i>2018 Apr 05. MeSH Terms: Oxidative Stress* / drug effects ; Diabetic Nephropathies / drug therapy ; Hyperglycemia / drug therapy ; Inflammation / drug therapy ; Kidney / pathology ; Lycium / chemistry ; Plant Extracts / therapeutic use ; Plant Leaves / *chemistry ; Animals ; Antioxidants / metabolism ; Biomarkers / blood ; Biomarkers / urine ; Diabetes Mellitus, Experimental / blood ; Diabetes Mellitus, Experimental / complications ; Diabetes Mellitus, Experimental / drug therapy ; Diabetes Mellitus, Experimental / pathology ; Diabetic Nephropathies / blood ; Diabetic Nephropathies / complications ; Diabetic Nephropathies / pathology ; Hyperglycemia / complications ; Hyperglycemia / pathology ; Hypertrophy ; Inflammation / complications ; Inflammation / pathology ; Kidney / drug effects ; Male ; Plant Extracts / pharmacology ; Rats, Sprague-Dawley ; Streptozocin ; Transforming Growth Factor beta1 / metabolism Contributed Indexing: Keywords: Diabetic nephropathy; Inﬂammation; Lycium chinense; Oxidative stress Substance Nomenclature: 0 (Antioxidants) ; 0 (Biomarkers) ; 0 (Plant Extracts) ; 0 (Transforming Growth Factor beta1) ; 5W494URQ81 (Streptozocin) Entry Date(s): Date Created: 20180502 Date Completed: 20181002 Latest Revision: 20181004 Update Code: 20240513

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