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Objectives: 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is useful for the detection of cancerous lesions, and FDG uptake is related to the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of extracranial tumors. The purpose of our study was to investigate the ability of FDG PET/CT in distinguishing primary central nervous system lymphoma (PCNSL) from glioblastoma multiforme (GBM) and to explore the relationship between 18 F-FDG uptake and the ADC in patients with PCNSL.

Methods: We reviewed 92 patients (40 with PCNSL and 52 with GBM) who underwent FDG PET/CT scans at disease onset. The maximum standardized uptake value (SUVmax), tumor to normal contralateral cortex activity (T/N) ratio, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of tumor lesions were calculated. Receiver operating characteristic (ROC) curves were generated to determine the diagnostic performance for FDG PET-related parameters to differentiate PCNSL from GBM. Twenty-eight patients with PCNSL (with 34 lesions) also underwent diffusion-weighted imaging. Pearson's correlation analysis was used to assess the relation between SUV- and ADC-derived parameters.

Results: The SUVmax, T/N ratio, SUVmean, and TLG values were significantly higher in PCNSL than in GBM. Comparative ROC analysis indicated that the SUVmax had a greater area under the curve (AUC) of 0.910 than the T/N ratio (0.905, P = .85), SUVmean (0.836, P = .0006), or TLG (0.641, P < 0.0001). The T/N ratio had the highest specificity (94.23%) for differentiating PCNSL from GBM, while the SUVmax had the most optimal sensitivity (92.31%). Further combined analysis of the indices did not significantly improve the AUC. Moderate inverse correlations between the SUVmax, SUVmean, TLG, and the ADC ratio (rADC) were found in PCNSLs (r = -0.526, P = .002; r = -0.504, P = .004; and r = -0.483, P = .006; respectively).

Conclusions: The SUVmax and T/N ratio may be reliable measures for differentiating PCNSLs from GBMs. Additionally, FDG metabolism indices were inversely proportional to the rADCs of PCNSL lesions.

Titel:	<superscript>18</superscript> F-FDG PET/CT in immunocompetent patients with primary central nervous system lymphoma: Differentiation from glioblastoma and correlation with DWI.
Autor/in / Beteiligte Person:	Zhou, W ; Wen, J ; Hua, F ; Xu, W ; Lu, X ; Yin, B ; Geng, D ; Guan, Y
Zeitschrift:	European journal of radiology, Jg. 104 (2018-07-01), S. 26-32
Veröffentlichung:	Limerick : Elsevier Science Ireland Ltd ; <i>Original Publication</i>: Stuttgart ; New York : Thieme, [c1981-, 2018
Medientyp:	academicJournal
ISSN:	1872-7727 (electronic)
DOI:	10.1016/j.ejrad.2018.04.020
Schlagwort:	Adult Aged Central Nervous System Neoplasms pathology Diagnosis, Differential Feasibility Studies Female Fluorodeoxyglucose F18 pharmacokinetics Glioblastoma pathology Humans Lymphoma, Non-Hodgkin pathology Male Middle Aged ROC Curve Radiopharmaceuticals pharmacokinetics Sensitivity and Specificity Central Nervous System Neoplasms diagnostic imaging Diffusion Magnetic Resonance Imaging Glioblastoma diagnostic imaging Lymphoma, Non-Hodgkin diagnostic imaging Positron-Emission Tomography methods Tomography, Emission-Computed
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Eur J Radiol] 2018 Jul; Vol. 104, pp. 26-32. <i>Date of Electronic Publication: </i>2018 Apr 22. MeSH Terms: Diffusion Magnetic Resonance Imaging* ; Positron-Emission Tomography* / methods ; Tomography, Emission-Computed* ; Central Nervous System Neoplasms / diagnostic imaging ; Glioblastoma / diagnostic imaging ; Lymphoma, Non-Hodgkin / *diagnostic imaging ; Adult ; Aged ; Central Nervous System Neoplasms / pathology ; Diagnosis, Differential ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18 / pharmacokinetics ; Glioblastoma / pathology ; Humans ; Lymphoma, Non-Hodgkin / pathology ; Male ; Middle Aged ; ROC Curve ; Radiopharmaceuticals / pharmacokinetics ; Sensitivity and Specificity Contributed Indexing: Keywords: Diffusion weighted imaging; FDG; Glioblastoma multiforme; PET/CT; Primary central nervous system lymphoma Substance Nomenclature: 0 (Radiopharmaceuticals) ; 0Z5B2CJX4D (Fluorodeoxyglucose F18) Entry Date(s): Date Created: 20180603 Date Completed: 20181219 Latest Revision: 20181219 Update Code: 20240513

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<superscript>18</superscript> F-FDG PET/CT in immunocompetent patients with primary central nervous system lymphoma: Differentiation from glioblastoma and correlation with DWI.