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Exposure to prolonged, uncontrollable stress reduces reward-seeking behavior, resulting in anhedonia in neuropsychiatric disorders, such as posttraumatic stress disorder. However, it is unclear to what degree stressed subjects lose interest in rewards themselves or in reward-related cues that instigate reward-seeking behavior. In the present study, we investigated the effects of single prolonged stress (SPS) on cue-directed behavior in two different procedures: Pavlovian conditioned approach (PCA) and cue-induced reinstatement of cocaine-seeking. In Experiment 1, rats were exposed to SPS and tested for the acquisition of sign-tracking (cue-directed) and goal-tracking (reward-directed) behaviors during a PCA procedure. In Experiment 2, rats were exposed to SPS and tested for the expression of sign- and goal-tracking as well as cue-induced reinstatement of cocaine-seeking. Because dopaminergic activity in the nucleus accumbens is known to play a central role in many cue-directed behaviors, including both sign-tracking and cue-induced reinstatement, Experiment 3 used in vivo microdialysis to measure the effect of SPS on baseline and evoked dopamine levels in the nucleus accumbens. SPS decreased sign-tracking and increased goal-tracking during the acquisition of PCA behavior without affecting reward consumption. In addition, SPS decreased cue-induced reinstatement without affecting cocaine self-administration. Finally, SPS decreased evoked but not baseline levels of dopamine in the nucleus accumbens. These results suggest that SPS decreases the motivational, but not consummatory, aspects of reward-seeking behavior, which may result from long-term, SPS-induced reductions in dopamine release in the nucleus accumbens.

Titel:	Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking.
Autor/in / Beteiligte Person:	Fitzpatrick, CJ ; Jagannathan, L ; Lowenstein, ED ; Robinson, TE ; Becker, JB ; Morrow, JD
Zeitschrift:	Behavioural brain research, Jg. 359 (2019-02-01), S. 799-806
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2019
Medientyp:	academicJournal
ISSN:	1872-7549 (electronic)
DOI:	10.1016/j.bbr.2018.07.026
Schlagwort:	Animals Conditioning, Classical drug effects Drug-Seeking Behavior physiology Male Rats Rats, Sprague-Dawley Self Administration Time Factors Cocaine administration & dosage Conditioning, Classical physiology Cues Dopamine Uptake Inhibitors administration & dosage Drug-Seeking Behavior drug effects Reinforcement, Psychology Stress, Psychological physiopathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Language: English [Behav Brain Res] 2019 Feb 01; Vol. 359, pp. 799-806. <i>Date of Electronic Publication: </i>2018 Aug 02. MeSH Terms: Cues* ; Reinforcement, Psychology* ; Cocaine / administration & dosage ; Conditioning, Classical / physiology ; Dopamine Uptake Inhibitors / administration & dosage ; Drug-Seeking Behavior / drug effects ; Stress, Psychological / *physiopathology ; Animals ; Conditioning, Classical / drug effects ; Drug-Seeking Behavior / physiology ; Male ; Rats ; Rats, Sprague-Dawley ; Self Administration ; Time Factors References: J Neurochem. 1999 May;72(5):2039-46. (PMID: 10217282) ; Pharmacol Biochem Behav. 1999 Sep;64(1):53-7. (PMID: 10494997) ; Brain Res Brain Res Rev. 1999 Dec;31(1):6-41. (PMID: 10611493) ; Brain Res. 2000 Apr 28;863(1-2):71-86. 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(PMID: 9858756) Grant Information: R01 DA039952 United States DA NIDA NIH HHS; R01 DA044960 United States DA NIDA NIH HHS; K08 DA037912 United States DA NIDA NIH HHS; P01 DA031656 United States DA NIDA NIH HHS; R01 DA012677 United States DA NIDA NIH HHS; T32 DA007281 United States DA NIDA NIH HHS Contributed Indexing: Keywords: Anhedonia; Dopamine; Incentive salience; Motivation; Nucleus accumbens; Pavlovian conditioned approach Substance Nomenclature: 0 (Dopamine Uptake Inhibitors) ; I5Y540LHVR (Cocaine) Entry Date(s): Date Created: 20180806 Date Completed: 20190403 Latest Revision: 20200226 Update Code: 20231215 PubMed Central ID: PMC6309754

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Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking.