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More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and we found approximately one-third of all signals to be sexually dimorphic. The 5% of individuals carrying the most WHRadjBMI-increasing alleles were 1.62 times more likely than the bottom 5% to have a WHR above the thresholds used for metabolic syndrome. These data, made publicly available, will inform the biology of body fat distribution and its relationship with disease.

Titel:	Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
Autor/in / Beteiligte Person:	Pulit, SL ; Stoneman, C ; Morris, AP ; Wood, AR ; Glastonbury, CA ; Tyrrell, J ; Yengo, L ; Ferreira, T ; Marouli, E ; Ji, Y ; Yang, J ; Jones, S ; Beaumont, R ; Croteau-Chonka, DC ; Winkler, TW ; Hattersley, AT ; Loos, RJF ; Hirschhorn, JN ; Visscher, PM ; Frayling, TM ; Yaghootkar, H ; Lindgren, CM
Link:	Full Text Finder (Volltext)
Zeitschrift:	Human molecular genetics, Jg. 28 (2019), Heft 1, S. 166-174
Veröffentlichung:	Oxford, England ; New York : IRL Press at Oxford University Press, c1992-, 2019
Medientyp:	academicJournal
ISSN:	1460-2083 (electronic)
DOI:	10.1093/hmg/ddy327
Schlagwort:	Adipose Tissue physiology Adult Alleles Body Mass Index Female Gene Frequency genetics Genetic Predisposition to Disease genetics Genome-Wide Association Study methods Humans Male Polymorphism, Single Nucleotide genetics Waist-Hip Ratio White People genetics Adiposity genetics Body Fat Distribution methods Obesity genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: GIANT Consortium Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Hum Mol Genet] 2019 Jan 01; Vol. 28 (1), pp. 166-174. MeSH Terms: Adiposity / genetics ; Body Fat Distribution / methods ; Obesity / *genetics ; Adipose Tissue / physiology ; Adult ; Alleles ; Body Mass Index ; Female ; Gene Frequency / genetics ; Genetic Predisposition to Disease / genetics ; Genome-Wide Association Study / methods ; Humans ; Male ; Polymorphism, Single Nucleotide / genetics ; Waist-Hip Ratio ; White People / genetics References: Nature. 2015 Feb 12;518(7538):187-196. (PMID: 25673412) ; Science. 2007 May 11;316(5826):889-94. (PMID: 17434869) ; Genome Biol. 2016 Jul 14;17(1):157. (PMID: 27418169) ; Nat Genet. 2017 Jan;49(1):125-130. (PMID: 27918534) ; Am J Hum Genet. 2011 Jan 7;88(1):76-82. (PMID: 21167468) ; Int J Epidemiol. 2010 Apr;39(2):417-20. (PMID: 19926667) ; N Engl J Med. 2017 Jan 19;376(3):254-266. (PMID: 28099824) ; Nat Genet. 2017 Jan;49(1):17-26. (PMID: 27841877) ; Diabetes. 2016 Aug;65(8):2448-60. (PMID: 27207519) ; PLoS Med. 2015 Mar 31;12(3):e1001779. (PMID: 25826379) ; Int J Epidemiol. 2018 Feb 1;47(1):226-235. (PMID: 29040562) ; Obes Res. 1998 Nov;6(6):383-92. (PMID: 9845227) ; Nature. 2015 Feb 12;518(7538):197-206. (PMID: 25673413) ; Nat Genet. 2015 Mar;47(3):284-90. (PMID: 25642633) ; JAMA. 2017 Feb 14;317(6):626-634. (PMID: 28196256) ; Nat Genet. 2016 Oct;48(10):1279-83. (PMID: 27548312) ; Am J Clin Nutr. 2005 Mar;81(3):555-63. (PMID: 15755822) ; Nat Genet. 2015 Mar;47(3):291-5. (PMID: 25642630) ; Nat Genet. 2015 Nov;47(11):1236-41. (PMID: 26414676) ; Gigascience. 2015 Feb 25;4:7. (PMID: 25722852) ; Genet Epidemiol. 2017 Feb;41(2):145-151. (PMID: 27990689) ; N Engl J Med. 2017 Jul 6;377(1):13-27. (PMID: 28604169) ; Diabetes. 2014 Dec;63(12):4378-4387. (PMID: 24947364) ; PLoS Genet. 2013 Jun;9(6):e1003500. (PMID: 23754948) ; Dis Model Mech. 2009 May-Jun;2(5-6):231-7. (PMID: 19407331) ; PLoS One. 2010 Sep 08;5(9):e12600. (PMID: 20838612) ; Bioinformatics. 2010 Sep 1;26(17):2190-1. (PMID: 20616382) ; Bioinformatics. 2015 Jan 15;31(2):259-61. (PMID: 25260699) ; Nature. 2007 Oct 18;449(7164):851-61. (PMID: 17943122) ; Am J Hum Genet. 2007 Sep;81(3):559-75. (PMID: 17701901) ; Am J Hum Genet. 2016 Feb 4;98(2):392-3. (PMID: 26849114) ; Nature. 2003 Dec 18;426(6968):789-96. (PMID: 14685227) ; Biosci Rep. 2017 Feb 3;37(1):. (PMID: 28073971) Grant Information: MC_PC_17228 United Kingdom MRC_ Medical Research Council; MR/M005070/1 United Kingdom MRC_ Medical Research Council; R01 DK075787 United States DK NIDDK NIH HHS; 323195 International ERC_ European Research Council; United Kingdom Wellcome Trust; 104150/Z/14/Z United Kingdom WT_ Wellcome Trust; M01 RR000070 United States RR NCRR NIH HHS; MC_QA137853 United Kingdom MRC_ Medical Research Council; P30 DK020541 United States DK NIDDK NIH HHS; K01 HL127265 United States HL NHLBI NIH HHS Entry Date(s): Date Created: 20180922 Date Completed: 20190614 Latest Revision: 20231104 Update Code: 20240513 PubMed Central ID: PMC6298238

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Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.