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Objective: Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments.

Results: 839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≥ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%).

Titel:	Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study.
Autor/in / Beteiligte Person:	Kopczynska, M ; Sharif, B ; Cleaver, S ; Spencer, N ; Kurani, A ; Lee, C ; Davis, J ; Durie, C ; Joseph-Gubral, J ; Sharma, A ; Allen, L ; Atkins, B ; Gordon, A ; Jones, L ; Noble, A ; Bradley, M ; Atkinson, H ; Inns, J ; Penney, H ; Gilbert, C ; Walford, R ; Pike, L ; Edwards, R ; Howcroft, R ; Preston, H ; Gee, J ; Doyle, N ; Maden, C ; Smith, C ; Nik Azis, NS ; Vadivale, N ; Szakmany, T
Link:	Volltext (PDF) View record at Springer (Volltext)
Zeitschrift:	BMC research notes, Jg. 11 (2018-10-11), Heft 1, S. 720
Veröffentlichung:	London : Biomed Central, 2008., 2018
Medientyp:	academicJournal
ISSN:	1756-0500 (electronic)
DOI:	10.1186/s13104-018-3819-2
Schlagwort:	Adolescent Adult Aged Aged, 80 and over Cross-Sectional Studies Female Hospitals statistics & numerical data Humans Male Middle Aged Organ Dysfunction Scores Prevalence Risk Factors Sepsis epidemiology Sepsis pathology United Kingdom epidemiology Cause of Death trends Emergency Service, Hospital statistics & numerical data Hospital Mortality trends Patients' Rooms statistics & numerical data Sepsis mortality
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: Welsh Digital Data Collection Platform Collaborators Publication Type: Journal Article Language: English [BMC Res Notes] 2018 Oct 11; Vol. 11 (1), pp. 720. <i>Date of Electronic Publication: </i>2018 Oct 11. MeSH Terms: Cause of Death / trends ; Emergency Service, Hospital / statistics & numerical data ; Hospital Mortality / trends ; Patients' Rooms / statistics & numerical data ; Sepsis / *mortality ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Hospitals / statistics & numerical data ; Humans ; Male ; Middle Aged ; Organ Dysfunction Scores ; Prevalence ; Risk Factors ; Sepsis / epidemiology ; Sepsis / pathology ; United Kingdom / epidemiology References: J Crit Care. 2018 Jun;45:33-39. (PMID: 29413720) ; PLoS One. 2016 Dec 1;11(12):e0167230. (PMID: 27907062) ; BMC Infect Dis. 2016 Jul 13;16:330. (PMID: 27412337) ; Intensive Care Med. 2018 Sep;44(9):1400-1426. (PMID: 29971592) ; Lancet Infect Dis. 2015 May;15(5):581-614. (PMID: 25932591) ; J Am Med Inform Assoc. 2016 Nov;23(6):1185-1189. (PMID: 27094989) ; Popul Health Metr. 2018 Feb 12;16(1):4. (PMID: 29433513) ; Trends Mol Med. 2014 Apr;20(4):195-203. (PMID: 24581450) ; Am J Respir Crit Care Med. 2017 Apr 1;195(7):906-911. (PMID: 27649072) ; Crit Care Med. 2006 Feb;34(2):344-53. (PMID: 16424713) ; Nurs Crit Care. 2018 Jul 24;:null. (PMID: 30039637) ; Crit Care Med. 2001 Jul;29(7):1303-10. (PMID: 11445675) ; J Intensive Care Med. 2017 Jan 1;:885066617715251. (PMID: 28675981) ; Crit Care Med. 2018 Jun;46(6):839-842. (PMID: 29762395) ; CMAJ. 2005 Aug 30;173(5):489-95. (PMID: 16129869) ; PLoS One. 2017 Nov 17;12(11):e0187990. (PMID: 29149187) ; Anaesthesia. 2018 Feb;73(2):195-204. (PMID: 29150856) ; JAMA. 2016 Feb 23;315(8):801-10. (PMID: 26903338) ; Crit Care Med. 2018 Nov;46(11):1753-1760. (PMID: 30024430) ; Emerg Med J. 2016 Jan;33(1):37-41. (PMID: 25971890) Grant Information: 2016 Fiona Elizabeth Agnew Trust Features Award; 2015 Welsh Intensive Care Society Contributed Indexing: Investigator: R Pugh; C Battle; R Lyons; P Morgan; M Hobrok; I Otahal; P Havalda; V Hamlyn; L Macchiavello; R Jones; O Minik; P Morgan; G Ellis; C Brown; C Littler; A Campbell; D George; C Subbe; JE Hall; S Szoke; R Self; U Gunter; RM Lundin; M Alsaeed; H Williams; A Ayob; N Farzana; S Parida; D Lawson; M Mazur; L D'Souza; B Ponting; T Lau; R Kerrigan; L Morgan; R Vindla; C Zeicu; B James; AA Ariff; WBW Azzlan; C Collins; E Wickens; A Norbee; A Zulkefli; T Haddock; M Thomas; M Lee; A Dandawate; H Shayan-Arani; E Taylor; O Kyriakides; R Price; FH Mackey; E Haines; S Chun; C Roberts; A Waller; L Heekin; K Wang; R Church; S Patel; M Broderick; H Whillis; DC Hathaway; E Yildirim; C Atkins; AG Mounce; A Ramjeeawon; N Mtunzi; D Soppitt; J Hale; J Wellington; RB Ross; D Lis; S Stovold; S Vickery; N Jones; A O'Donnell; M Cuthbert; O Eghosa; M Karim; L Williams; L Tucker; T Downs; A MacNaught; S Balachandran; A Shipley; JL Kent; T Roberts; S Tilley; B Davies; E Withers; K Parmar; L Webber; T Grother; H Smith; R Watson; N Hoyle; RC El Alaoui; O Marei; E Kirby; A Gilfedder; L Maw; S O'Connor; A Rogers; ZX Tan; C Chantrill; A Robertson; J Foulkes; R Khanam; J John; I Sutherland; SH Meehan; H Metezai; H Dawson; E Baxendale; K Khan; P Myat; A Forrester; O Moore; HJ Lim; A Owen; F Hussain; NB Allybocus; M Sethi; U Asim; E Boggon; I Alkurd; G Lawrence; J Brown; LH Thomas; E Murphy; E Lambert; J Guilford; B Payne; M Almulaifi; A Poacher; S Ganesananthan; S Tanatova; J Kew; ME Clark; E Hannay; O Godsafe; C Houghton; F Lavric; R Mallinson; HMP Chan; E Ang; N McSwiney; YY Lim; ZX Lee; S Kulikouskaya; N Zulkifli; S Lim; L Xin; T Chandy; A Taufik; J Cochrane; S Davies; S Willis; J Lynch; SY Heng; A Cooper; HG von der Pahlen; I Talbot; RG Roberts; JS Smith; A Sweeney; C Roberts; P McNulty; E Walters; R Sinnerton; B Tanner; B Cunningham-Walker; C Spooner; A Kiran; N Nadeem; V Unadkat; JNC Hui; E Sparey; D Li; J Smith; I Corrin; H Waring; A Khan; E Baker; MY Amjad; M Cynan; I Hay; C Russell; J Davies; R Parsonson; A Arunthavarajah; J Nicholas; A Harris; T Burnett; JR Gowar; S DeFriend; H Jones; NAB Maliki; M Zimmerman; J Webber; R Phillips; L McCarthy; L Wirt; E Hubbard; E Evans; LJ Davis; LW Davies; L Sanders-Crook; A Dhadda; G Logue; I Jones; A Urazbayeva; NHA Hanif; YK Ying; A Coleclough; E Higgins; TG Ng; S Booth; N Vignarajah; T Chamberlain; D Zhao; NN Tantirige; J Watts; A Prideaux; A Tee; A Hook; A Mounce; E Eccles; K Ramesh; L Bausor; A Handley; R Paddock; L Banerjee ; Keywords: Critical care; Frailty; Mortality; Sepsis Entry Date(s): Date Created: 20181013 Date Completed: 20181231 Latest Revision: 20220409 Update Code: 20240513 PubMed Central ID: PMC6182791

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Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study.