Functional Biomarkers for Amyotrophic Lateral Sclerosis.
In: Frontiers in neurology, Jg. 9 (2019-01-04), S. 1141
Online
academicJournal
Zugriff:
The clinical diagnosis of amyotrophic lateral sclerosis (ALS) relies on determination of progressive dysfunction of both cortical as well as spinal and bulbar motor neurons. However, the variable mix of upper and lower motor neuron signs result in the clinical heterogeneity of patients with ALS, resulting frequently in delay of diagnosis as well as difficulty in monitoring disease progression and treatment outcomes particularly in a clinical trial setting. As such, the present review provides an overview of recently developed novel non-invasive electrophysiological techniques that may serve as biomarkers to assess UMN and LMN dysfunction in ALS patients.
Titel: |
Functional Biomarkers for Amyotrophic Lateral Sclerosis.
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Autor/in / Beteiligte Person: | Huynh, W ; Dharmadasa, T ; Vucic, S ; Kiernan, MC |
Link: | |
Zeitschrift: | Frontiers in neurology, Jg. 9 (2019-01-04), S. 1141 |
Veröffentlichung: | [Lausanne : Frontiers Research Foundation, 2010]-, 2019 |
Medientyp: | academicJournal |
ISSN: | 1664-2295 (print) |
DOI: | 10.3389/fneur.2018.01141 |
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