The Burden of Severe Asthma in France: A Case-Control Study Using a Medical Claims Database.
In: The journal of allergy and clinical immunology. In practice, Jg. 7 (2019-05-01), Heft 5, S. 1477-1487
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Zugriff:
Background: Severe asthma (SA) is defined by treatment intensity. The availability of national databases allows accurate estimation of the prevalence, long-term outcomes, and costs of SA.
Objective: To provide accurate information on SA, focusing on comorbidities, mortality, health care resource consumption, and associated costs.
Methods: A cohort of patients with SA identified in 2012 was extracted from a French representative claims database and followed for 3 years. Their characteristics, comorbidities, mortality, and direct costs were compared with a matched control group without asthma.
Results: A total of 690 patients with SA were matched to 2070 patients without asthma (mean age, 61 years; 65.7% women). The prevalence of SA was estimated to be 0.18% to 0.51% of the French adult population. Comorbidities were more frequent in patients with SA (73.9% suffered from cardiovascular disease vs 54.3% in controls; P < .001). A total of 58.7% of patients with SA used oral corticosteroids (OCS) in 2012 with a mean intake of 3.3 boxes/year/patient and 9% received ≥6 dispensings of OCS. A total of 6.7% were treated by omalizumab. Patients with SA were more frequently hospitalized (33.2% vs 19.7%; P < .001), more frequently consulted a general practitioner (97.8% vs 83.9%; P < .001) (9.8 ± 6.8 vs 6.2 ± 5.3 consultations/year; P < .001), and 31% have consulted a private respiratory physician. Compared with controls, 3-year cumulative mortality was higher in SA (7.1% vs 4.5%; P = .007). Direct medical cost was $9227 versus $3950 (P < .001) mostly driven by medication costs.
Conclusions: The prevalence of SA in the French adult population is at least 18 of 10,000. Burden of disease is high with respect to comorbidities, mortality, and asthma-related health care resource use.
(Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
Titel: |
The Burden of Severe Asthma in France: A Case-Control Study Using a Medical Claims Database.
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Autor/in / Beteiligte Person: | Bourdin, A ; Fabry-Vendrand, C ; Ostinelli, J ; Ait-Yahia, M ; Darnal, E ; Bouee, S ; Laurendeau, C ; Bureau, I ; Gourmelen, J ; Chouaid, C |
Zeitschrift: | The journal of allergy and clinical immunology. In practice, Jg. 7 (2019-05-01), Heft 5, S. 1477-1487 |
Veröffentlichung: | New York, NY : Elsevier Inc., [2013]-, 2019 |
Medientyp: | academicJournal |
ISSN: | 2213-2201 (electronic) |
DOI: | 10.1016/j.jaip.2018.12.029 |
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