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Objectives: Long bone defects often require surgical intervention for functional restoration. The 'gold standard' treatment is autologous bone graft (ABG), usually from the patient's iliac crest. However, autograft is plagued by complications including limited supply, donor site morbidity, and the need for an additional surgery. Thus, alternative therapies are being actively investigated. Autologous bone marrow (BM) is considered as a candidate due to the presence of both endogenous reparative cells and growth factors. We aimed to compare the therapeutic potentials of autologous bone marrow aspirate (BMA) and ABG, which has not previously been done.

Methods: We compared the efficacy of coagulated autologous BMA and ABG for the repair of ulnar defects in New Zealand White rabbits. Segmental defects (14 mm) were filled with autologous clotted BM or morcellized autograft, and healing was assessed four and 12 weeks postoperatively. Harvested ulnas were subjected to radiological, micro-CT, histological, and mechanical analyses.

Results: Comparable results were obtained with autologous BMA clot and ABG, except for the quantification of new bone by micro-CT. Significantly more bone was found in the ABG-treated ulnar defects than in those treated with autologous BMA clot. This is possibly due to the remnants of necrotic autograft fragments that persisted within the healing defects at week 12 post-surgery.

Conclusion: As similar treatment outcomes were achieved by the two strategies, the preferred treatment would be one that is associated with a lower risk of complications. Hence, these results demonstrate that coagulated BMA can be considered as an alternative autogenous therapy for long bone healing. Cite this article : Z. X. H. Lim, B. Rai, T. C. Tan, A. K. Ramruttun, J. H. Hui, V. Nurcombe, S. H. Teoh, S. M. Cool. Autologous bone marrow clot as an alternative to autograft for bone defect healing. Bone Joint Res 2019;8:107-117. DOI: 10.1302/2046-3758.83.BJR-2018-0096.R1.

Titel:	Autologous bone marrow clot as an alternative to autograft for bone defect healing.
Autor/in / Beteiligte Person:	Lim, ZXH ; Rai, B ; Tan, TC ; Ramruttun, AK ; Hui, JH ; Nurcombe, V ; Teoh, SH ; Cool, SM
Link:	Full Text Finder (Volltext)
Zeitschrift:	Bone & joint research, Jg. 8 (2019-04-02), Heft 3, S. 107-117
Veröffentlichung:	London, England : British Editorial Society of Bone & Joint Surgery, 2019
Medientyp:	academicJournal
ISSN:	2046-3758 (print)
DOI:	10.1302/2046-3758.83.BJR-2018-0096.R1
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Bone Joint Res] 2019 Apr 02; Vol. 8 (3), pp. 107-117. <i>Date of Electronic Publication: </i>2019 Apr 02 (<i>Print Publication: </i>2019). References: Spine (Phila Pa 1976). 1999 Mar 1;24(5):434-8; discussion 438-9. (PMID: 10084179) ; Med Hypotheses. 2000 Dec;55(6):474-9. (PMID: 11090293) ; Angiogenesis. 2001;4(1):37-43. (PMID: 11824377) ; Thromb Haemost. 2002 Aug;88(2):186-93. (PMID: 12195687) ; J Cell Biochem. 2002;87(3):305-12. (PMID: 12397612) ; Biomaterials. 2003 Apr;24(9):1643-51. (PMID: 12559824) ; Br J Haematol. 2003 Jun;121(6):949-51. (PMID: 12786808) ; Biotech Histochem. 1992 Nov;67(6):339-45. (PMID: 1283340) ; Bone. 2004 Dec;35(6):1316-22. (PMID: 15589212) ; J Am Acad Orthop Surg. 2005 Jan-Feb;13(1):77-86. (PMID: 15712985) ; J Clin Pathol. 2005 Apr;58(4):406-8. (PMID: 15790706) ; Spine (Phila Pa 1976). 2005 May 1;30(9):1001-7; discussion 1007. (PMID: 15864149) ; Neurosurgery. 2005 Oct;57(4 Suppl):286-9; discussion 286-9. (PMID: 16234676) ; Spine (Phila Pa 1976). 2006 Jan 1;31(1):11-7. (PMID: 16395170) ; Spine (Phila Pa 1976). 2006 Aug 15;31(18):E636-40. (PMID: 16915079) ; Cytotherapy. 2006;8(4):315-7. (PMID: 16923606) ; Blood. 2008 Feb 1;111(3):1227-33. (PMID: 17962514) ; Biochem Biophys Res Commun. 2008 Oct 17;375(2):261-4. (PMID: 18706392) ; Clin J Am Soc Nephrol. 2008 Nov;3 Suppl 3:S131-9. (PMID: 18988698) ; Implant Dent. 2009 Apr;18(2):132-41. (PMID: 19359864) ; Eur Spine J. 2009 Nov;18(11):1610-20. (PMID: 19475437) ; Orthop Clin North Am. 2010 Jan;41(1):15-26; table of contents. (PMID: 19931049) ; Spine (Phila Pa 1976). 2011 Mar 15;36(6):441-7. (PMID: 21124263) ; Proc Inst Mech Eng H. 2010 Dec;224(12):1329-43. (PMID: 21287823) ; Tissue Eng Part A. 2011 Oct;17(19-20):2389-97. (PMID: 21682591) ; Injury. 2011 Sep;42 Suppl 2:S3-15. (PMID: 21704997) ; Craniomaxillofac Trauma Reconstr. 2008 Nov;1(1):49-61. (PMID: 22110789) ; Bone. 2012 Apr;50(4):954-64. (PMID: 22227436) ; J Tissue Eng Regen Med. 2013 May;7(5):392-400. (PMID: 22392849) ; Biomaterials. 2012 Sep;33(26):6113-22. (PMID: 22687758) ; Tissue Eng Part B Rev. 2013 Aug;19(4):308-26. (PMID: 23268651) ; J Bone Joint Surg Am. 2013 Jan 16;95(2):158-66. (PMID: 23324964) ; J Bone Joint Surg Am. 2013 Feb 20;95(4):338-47. (PMID: 23426768) ; J Photochem Photobiol B. 2013 Apr 5;121:6-14. (PMID: 23474527) ; Biomaterials. 2013 Jul;34(22):5594-605. (PMID: 23632323) ; Clin Orthop Relat Res. 1990 Jul;(256):280-5. (PMID: 2364614) ; J Cell Sci. 2013 Sep 15;126(Pt 18):4085-98. (PMID: 23843612) ; Int Orthop. 2014 Sep;38(9):1855-60. (PMID: 24658874) ; J Tissue Eng Regen Med. 2015 Aug;9(8):889-902. (PMID: 24916192) ; PLoS One. 2015 Mar 17;10(3):e0119603. (PMID: 25781027) ; Acta Biomater. 2015 Dec;28:193-204. (PMID: 26384700) ; Connect Tissue Res. 2017 Mar;58(2):208-214. (PMID: 27462987) ; J Cell Physiol. 2018 Apr;233(4):2723-2732. (PMID: 28639702) ; Bone Joint J. 2018 May 1;100-B(5):667-674. (PMID: 29701102) ; Clin Orthop Relat Res. 1986 Jul;(208):300-12. (PMID: 3522026) ; Clin Orthop Relat Res. 1985 Nov;(200):125-41. (PMID: 3905105) ; Transplantation. 1968 Mar;6(2):230-47. (PMID: 5654088) ; Clin Orthop Relat Res. 1995 Apr;(313):8-18. (PMID: 7641502) ; J Bone Joint Surg Am. 1994 Jun;76(6):827-38. (PMID: 8200889) ; J Foot Ankle Surg. 1996 Sep-Oct;35(5):413-7. (PMID: 8915864) ; Int J Oral Maxillofac Surg. 1997 Feb;26(1):55-60. (PMID: 9081257) ; J Bone Joint Surg Am. 1997 Nov;79(11):1699-709. (PMID: 9384430) ; Biomed Mater Eng. 1998;8(1):1-9. (PMID: 9713681) Contributed Indexing: Keywords: Autologous bone graft; Bone mineralization; Bone repair; Coagulated autologous bone marrow aspirate; Defect healing Entry Date(s): Date Created: 20190419 Latest Revision: 20220408 Update Code: 20231215 PubMed Central ID: PMC6444063

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