Einzeltreffer — DigiBib

Background: Cerebral small vessel diseases (SVD) are associated with poststroke depressive symptoms (PDS). The mechanisms underlying the association between SVD burden and PDS are unclear. This study investigated the clinical pathways linking SVD burden to PDS.

Method: A cohort of 563 patients with acute ischemic stroke were examined at three and fifteen months after stroke. PDS was measured with the 15-item Geriatric Depression Scale (GDS). Cognitive and physical functions were assessed with the Mini-Mental State Examination and the modified Rankin Scale, respectively. All patients received MRI scans at baseline. Infarct volumes and the four SVD markers (lacunae, white matter hyperintensities, cerebral microbleeds, and perivascular spaces) were assessed on magnetic resonance imaging. SVD burden was defined as a latent variable encompassing the information about all four SVD markers in structural equation modeling (SEM). SEM was further employed to examine the direct and indirect linking pathways between SVD burden, infarct volumes, stroke severity, poststroke cognitive and physical dysfunctions, and PDS.

Results: The latent SVD burden was directly associated with more severe PDS at the 3-month follow-up (path coefficient=0.11), while SVD burden and PDS at the 15-month were mainly linked through PDS at the 3-month follow-up (path coefficient=0.48). The volume of acute infarcts and impaired physical functions predominantly mediated the association between SVD burden and PDS at 3-month follow-up. Physical and cognitive functions 15 months after stroke mainly bridged the link between SVD burden and the PDS at the 15-month follow-up.

Limitations: The study included patients with mild stroke, which reduced the generalizability of the findings.

Conclusions: SVD burden not only directly determines poststroke depressive symptoms, but also worsens acute stroke lesions, stroke severity, and poststroke neurological deficits, thereby contributing further to the development of PDS over the first 15 months after stroke.

Titel:	Exploring causal pathways linking cerebral small vessel diseases burden to poststroke depressive symptoms with structural equation model analysis.
Autor/in / Beteiligte Person:	Liang, Y ; Chen, YK ; Liu, YL ; Mok, VCT ; Ungvari, GS ; Chu, WCW ; Tang, WK ; Kim, JS ; Kim, JM
Zeitschrift:	Journal of affective disorders, Jg. 253 (2019-06-15), S. 218-223
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2019
Medientyp:	academicJournal
ISSN:	1573-2517 (electronic)
DOI:	10.1016/j.jad.2019.04.092
Schlagwort:	Aged Brain Ischemia psychology Cerebral Small Vessel Diseases physiopathology Cognition Cognition Disorders Cohort Studies Depression physiopathology Female Humans Magnetic Resonance Imaging Male Middle Aged Stroke psychology Brain Ischemia complications Cerebral Small Vessel Diseases etiology Depression etiology Stroke complications
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Affect Disord] 2019 Jun 15; Vol. 253, pp. 218-223. <i>Date of Electronic Publication: </i>2019 Apr 22. MeSH Terms: Brain Ischemia / complications ; Cerebral Small Vessel Diseases / etiology ; Depression / etiology ; Stroke / complications ; Aged ; Brain Ischemia / psychology ; Cerebral Small Vessel Diseases / physiopathology ; Cognition ; Cognition Disorders ; Cohort Studies ; Depression / physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Stroke / psychology Contributed Indexing: Keywords: Abbreviations: CFI, Comparative fit index; Acute ischemic stroke; CMB, Cerebral microbleeds; Cerebral small vessel disease; Depressive symptoms; EPVS, Enlarged perivascular spaces; FLAIR, Fluid attenuated inversion recovery; GDS, Geriatric Depression Scale; LSNS, Lubben Social Network Scale; MMSE, Mini-Mental State Examination; MRI, Magnetic resonance imaging; NIHSS, National Institutes of Health Stroke Scale; PDS, Poststroke depressive symptoms; RMSEA, Root mean square error of approximation; SEM, Structural equation modelling; SVD, Small vessel diseases; Structural equation modeling; WMH, White matter hyperintensities; mRS, Modified Rankin Scale Entry Date(s): Date Created: 20190505 Date Completed: 20200406 Latest Revision: 20200408 Update Code: 20231215

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Exploring causal pathways linking cerebral small vessel diseases burden to poststroke depressive symptoms with structural equation model analysis.