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Layered double hydroxide nanoparticles (LDHs) have shown the excellent capability and good adjuvant function as a nanocarrier for protein antigen delivery to enhance the immune response. Furthermore, LDHs have good biocompatibility and low cytotoxicity. However, their oral vaccine delivery efficiency is limited due to acidic/enzyme degradation in the stomach and low bioavailability in the small intestine. To overcome these challenges, alginate-chitosan coated LDHs nanocomposites (ALG-CHT-LDH) have been developed and used as a carrier for oral protein vaccine delivery. The physicochemical properties of ALG-CHT-LDH have been determined by dynamic light scattering (DLS), transmission electron microscopy (TEM), and ultraviolet visible (UV-Vis) spectroscopy. Protein release properties of LDHs with/without polymer coating have been investigated at various pHs. The protein release profile of ALG-CHT-LDH nanocomposites indicated that ALG-CHT coating could partially protect protein release at the acidic condition (pH 1.2). The cellular uptake efficiency of protein delivered by ALG-CHT-LDH for the intestine cells and macrophages were studied. After alginate layer falls from ALG-CHT-LDH nanocomposite, flow cytometry analysis (FACS) data suggest that chitosan-coated LDHs significantly enhance the internalization of proteins at the Caco2 and macrophage cells.

Titel:	Alginate-chitosan coated layered double hydroxide nanocomposites for enhanced oral vaccine delivery.
Autor/in / Beteiligte Person:	Yu, X ; Wen, T ; Cao, P ; Shan, L ; Li, L
Zeitschrift:	Journal of colloid and interface science, Jg. 556 (2019-11-15), S. 258-265
Veröffentlichung:	Orlando, FL : Academic Press ; <i>Original Publication</i>: New York., 2019
Medientyp:	academicJournal
ISSN:	1095-7103 (electronic)
DOI:	10.1016/j.jcis.2019.08.027
Schlagwort:	Administration, Oral Animals Caco-2 Cells HT29 Cells Humans Mice RAW 264.7 Cells Alginates chemistry Alginates pharmacology Chitosan chemistry Chitosan pharmacology Drug Carriers chemistry Drug Carriers pharmacology Hydroxides chemistry Hydroxides pharmacology Nanocomposites chemistry Nanocomposites therapeutic use Vaccines chemistry Vaccines pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Colloid Interface Sci] 2019 Nov 15; Vol. 556, pp. 258-265. <i>Date of Electronic Publication: </i>2019 Aug 09. MeSH Terms: Alginates* / chemistry ; Alginates* / pharmacology ; Chitosan* / chemistry ; Chitosan* / pharmacology ; Drug Carriers* / chemistry ; Drug Carriers* / pharmacology ; Hydroxides* / chemistry ; Hydroxides* / pharmacology ; Nanocomposites* / chemistry ; Nanocomposites* / therapeutic use ; Vaccines* / chemistry ; Vaccines* / pharmacology ; Administration, Oral ; Animals ; Caco-2 Cells ; HT29 Cells ; Humans ; Mice ; RAW 264.7 Cells Contributed Indexing: Keywords: Alginate; Chitosan; Layered double hydroxide nanoparticle; Oral delivery; Polymer coating Substance Nomenclature: 0 (Alginates) ; 0 (Drug Carriers) ; 0 (Hydroxides) ; 0 (Vaccines) ; 9012-76-4 (Chitosan) Entry Date(s): Date Created: 20190827 Date Completed: 20200219 Latest Revision: 20200219 Update Code: 20240513

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Alginate-chitosan coated layered double hydroxide nanocomposites for enhanced oral vaccine delivery.