CXCL9/CXCL10 angiostasis CXC-chemokines in parallel with the CXCL12 as an angiogenesis CXC-chemokine are variously expressed in pre-eclamptic-women and their neonates.

Darakhshan, S ; Hassanshahi, G ; et al.

In: Pregnancy hypertension, Jg. 17 (2019-07-01), S. 36-42

academicJournal

Background: The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis chemokines as well as CXCL12 as an angiogenesis, homeostatic chemokine, in pregnant women with and without pre-eclampsia and their neonates.

Methods: Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these chemokines were investigated by ELISA and western blot analysis, respectively.

Results: Findings of the present study demonstrated that the levels of CXCL9 chemokine in parallel with CXCL12 as homeostatic chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers.

Conclusion: According to the results, the CXC chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.

Titel:	CXCL9/CXCL10 angiostasis CXC-chemokines in parallel with the CXCL12 as an angiogenesis CXC-chemokine are variously expressed in pre-eclamptic-women and their neonates.
Autor/in / Beteiligte Person:	Darakhshan, S ; Hassanshahi, G ; Mofidifar, Z ; Soltani, B ; Karimabad, MN
Zeitschrift:	Pregnancy hypertension, Jg. 17 (2019-07-01), S. 36-42
Veröffentlichung:	Amtserdam : Elsevier, 2019
Medientyp:	academicJournal
ISSN:	2210-7797 (electronic)
DOI:	10.1016/j.preghy.2019.05.001
Schlagwort:	Adult Biomarkers blood Case-Control Studies Chemokine CXCL10 blood Chemokine CXCL10 metabolism Chemokine CXCL12 blood Chemokine CXCL12 metabolism Chemokine CXCL9 blood Chemokine CXCL9 metabolism Chemokines, CXC blood Cordocentesis Enzyme-Linked Immunosorbent Assay Female Humans Infant, Newborn Pre-Eclampsia blood Predictive Value of Tests Pregnancy Sensitivity and Specificity Biomarkers metabolism Chemokines, CXC metabolism Pre-Eclampsia metabolism Prenatal Diagnosis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Evaluation Study; Journal Article Language: English [Pregnancy Hypertens] 2019 Jul; Vol. 17, pp. 36-42. <i>Date of Electronic Publication: </i>2019 May 03. MeSH Terms: Prenatal Diagnosis* ; Biomarkers / metabolism ; Chemokines, CXC / metabolism ; Pre-Eclampsia / *metabolism ; Adult ; Biomarkers / blood ; Case-Control Studies ; Chemokine CXCL10 / blood ; Chemokine CXCL10 / metabolism ; Chemokine CXCL12 / blood ; Chemokine CXCL12 / metabolism ; Chemokine CXCL9 / blood ; Chemokine CXCL9 / metabolism ; Chemokines, CXC / blood ; Cordocentesis ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Infant, Newborn ; Pre-Eclampsia / blood ; Predictive Value of Tests ; Pregnancy ; Sensitivity and Specificity Contributed Indexing: Keywords: CXCL10; CXCL12; Chemokine; Preeclampsia; Pregnancy Substance Nomenclature: 0 (Biomarkers) ; 0 (CXCL12 protein, human) ; 0 (Chemokine CXCL10) ; 0 (Chemokine CXCL12) ; 0 (Chemokine CXCL9) ; 0 (Chemokines, CXC) Entry Date(s): Date Created: 20190906 Date Completed: 20200219 Latest Revision: 20200219 Update Code: 20240513

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