Interactions of multiple gene alterations in colorectal liver metastases.
In: Chinese clinical oncology, Jg. 8 (2019-10-01), Heft 5, S. 50
academicJournal
Zugriff:
The advancements in next generation sequencing have expanded the information available in clinical practice. Alterations of TP53, APC, RAS, PIK3CA, and SMAD4 are present in more than 10% of patients with colorectal liver metastases (CLM). Of these genes, TP53, RAS and SMAD4 were associated with worse survival in patients undergoing CLM resection. Testing multiple gene alterations provides a more precise prognosis for patients undergoing CLM resection and may be useful for better clinical decision making.
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Interactions of multiple gene alterations in colorectal liver metastases.
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Autor/in / Beteiligte Person: | Kawaguchi, Y ; Velasco, JD ; Arvide, EM ; Wei, SH ; Vauthey, JN |
Zeitschrift: | Chinese clinical oncology, Jg. 8 (2019-10-01), Heft 5, S. 50 |
Veröffentlichung: | Hong Kong : AME Publishing Company, 2019 |
Medientyp: | academicJournal |
ISSN: | 2304-3873 (electronic) |
DOI: | 10.21037/cco.2019.08.06 |
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