Risk of Neurological Disorders in Patients With European Lyme Neuroborreliosis: A Nationwide, Population-Based Cohort Study.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jg. 71 (2020-09-12), Heft 6, S. 1511-1516
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Zugriff:
Background: Lyme neuroborreliosis (LNB), caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu lato species complex, has been suggested to be associated with a range of neurological disorders. In a nationwide, population-based cohort study, we examined the associations between LNB and dementia, Alzheimer's disease, Parkinson's disease, motor neuron disease, epilepsy, and Guillain-Barré syndrome.
Methods: We used national registers to identify all Danish residents diagnosed during 1986-2016 with LNB (n = 2067), created a gender- and age-matched comparison cohort from the general population (n = 20 670), and calculated risk estimates and hazard ratios.
Results: We observed no long-term increased risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, or epilepsy. However, within the first year, 8 (0.4%) of the LNB patients developed epilepsy, compared with 20 (0.1%) of the comparison cohort (difference, 0.3%; 95% confidence interval, .02-.6%). In the LNB group, 11 (0.5%) patients were diagnosed with Guillain-Barré syndrome within the first year after LNB diagnosis, compared with 0 (0.0%) in the comparison cohort. After the first year, the risk of Guillain-Barré was not increased.
Conclusions: LNB patients did not have increased long-term risks of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, epilepsy, or Guillain-Barré. Although the absolute risk is low, LNB patients might have an increased short-term risk of epilepsy and Guillain-Barré syndrome.
(© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
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Risk of Neurological Disorders in Patients With European Lyme Neuroborreliosis: A Nationwide, Population-Based Cohort Study.
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Autor/in / Beteiligte Person: | Haahr, R ; Tetens, MM ; Dessau, RB ; Krogfelt, KA ; Bodilsen, J ; Andersen, NS ; Møller, JK ; Roed, C ; Christiansen, CB ; Ellermann-Eriksen, S ; Bangsborg, JM ; Hansen, K ; Benfield, TL ; Andersen, CØ ; Obel, N ; Lebech, AM ; Omland, LH |
Zeitschrift: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jg. 71 (2020-09-12), Heft 6, S. 1511-1516 |
Veröffentlichung: | Jan. 2011- : Oxford : Oxford University Press ; <i>Original Publication</i>: Chicago, IL : The University of Chicago Press, c1992-, 2020 |
Medientyp: | academicJournal |
ISSN: | 1537-6591 (electronic) |
DOI: | 10.1093/cid/ciz997 |
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