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Basal amygdala (BA) neurons guide associative learning via acquisition of responses to stimuli that predict salient appetitive or aversive outcomes. We examined the learning- and state-dependent dynamics of BA neurons and ventral tegmental area (VTA) dopamine (DA) axons that innervate BA (VTA DA→BA ) using two-photon imaging and photometry in behaving mice. BA neurons did not respond to arbitrary visual stimuli, but acquired responses to stimuli that predicted either rewards or punishments. Most VTA DA→BA axons were activated by both rewards and punishments, and they acquired responses to cues predicting these outcomes during learning. Responses to cues predicting food rewards in VTA DA→BA axons and BA neurons in hungry mice were strongly attenuated following satiation, while responses to cues predicting unavoidable punishments persisted or increased. Therefore, VTA DA→BA axons may provide a reinforcement signal of motivational salience that invigorates adaptive behaviors by promoting learned responses to appetitive or aversive cues in distinct, intermingled sets of BA excitatory neurons.

Titel:	State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala.
Autor/in / Beteiligte Person:	Lutas, A ; Kucukdereli, H ; Alturkistani, O ; Carty, C ; Sugden, AU ; Fernando, K ; Diaz, V ; Flores-Maldonado, V ; Andermann, ML
Link:	View record at Springer (Volltext)
Zeitschrift:	Nature neuroscience, Jg. 22 (2019-11-01), Heft 11, S. 1820-1833
Veröffentlichung:	<2002->: New York, NY : Nature Publishing Group ; <i>Original Publication</i>: New York, NY : Nature America Inc., c1998-, 2019
Medientyp:	academicJournal
ISSN:	1546-1726 (electronic)
DOI:	10.1038/s41593-019-0506-0
Schlagwort:	Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Cues Dopamine Plasma Membrane Transport Proteins genetics Female Male Mice Mice, Transgenic Neural Pathways physiology Photic Stimulation Punishment Reward Visual Perception physiology Amygdala physiology Dopaminergic Neurons physiology Sensory Gating physiology Ventral Tegmental Area physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Nat Neurosci] 2019 Nov; Vol. 22 (11), pp. 1820-1833. <i>Date of Electronic Publication: </i>2019 Oct 14. MeSH Terms: Amygdala / physiology ; Dopaminergic Neurons / physiology ; Sensory Gating / physiology ; Ventral Tegmental Area / physiology ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Cues ; Dopamine Plasma Membrane Transport Proteins / genetics ; Female ; Male ; Mice ; Mice, Transgenic ; Neural Pathways / physiology ; Photic Stimulation ; Punishment ; Reward ; Visual Perception / physiology References: Burgess, C. R., Livneh, Y., Ramesh, R. N. & Andermann, M. L. Gating of visual processing by physiological need. Curr. Opin. Neurobiol. 49, 16–23 (2018). (PMID: 29125986) ; Johnson, A. W., Gallagher, M. & Holland, P. C. 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Grant Information: DP2 DK105570 United States DK NIDDK NIH HHS; P30 DK046200 United States DK NIDDK NIH HHS; F32 DK112589 United States DK NIDDK NIH HHS; T32 DK007516 United States DK NIDDK NIH HHS; R01 DK109930 United States DK NIDDK NIH HHS; T32 NS007484 United States NS NINDS NIH HHS Substance Nomenclature: 0 (Dopamine Plasma Membrane Transport Proteins) ; 0 (Slc6a3 protein, mouse) ; EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2) Entry Date(s): Date Created: 20191016 Date Completed: 20200131 Latest Revision: 20220417 Update Code: 20231215 PubMed Central ID: PMC6858554

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State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala.