Organ dose and total effective dose of whole-body CT in multiple myeloma patients.
In: Skeletal radiology, Jg. 49 (2020-04-01), Heft 4, S. 549-554
Online
academicJournal
Zugriff:
Objective: To evaluate organ dose and total effective dose of whole-body low-dose CT (WBLDCT) performed on different CT-scanner models in patients with multiple myeloma (MM) and to compare it to the effective dose of radiographic skeletal survey and representative diagnostic CTs.
Material and Methods: We retrospectively analyzed data from 228 patients (47.4% females, mean age 67.9 ± 10.4 years, mean weight 81.8 ± 22.4 kg) who underwent WBLDCT for the work-up or surveillance of MM. Patients were scanned using one of six multi-detector CT-scanners. Organ doses and total effective doses per scan were calculated using a commercially available dose-management platform (Radimetrics, Bayer Healthcare, Leverkusen, Germany). The median effective dose was compared to radiographic skeletal survey and representative diagnostic CTs.
Results: The mean effective dose of our WBLDCT-protocol was 4.82 mSv. A significantly higher effective dose was observed in females compared to males (4.95 vs. 4.70 mSv, P = 0.002). Mean organ dose ranged from 3.72 mSv (esophagus) to 13.09 mSv (skeleton). Mean effective dose varied amongst different CT-scanners (range 4.34-8.37 mSv). The median effective dose of WBLDCT was more than twice the dose of a skeletal survey (4.82 vs. 2.04 mSv), 23% higher than a diagnostic contrast-enhanced chest CT (3.9 mSv), 46% lower than a diagnostic contrast-enhanced abdomen/pelvis CT (9.0 mSv), and 45% lower than a lumbar spine CT (8.7 mSv).
Conclusions: WBLDCT in MM has a higher effective dose than a radiographic skeletal survey, but a lower effective dose than diagnostic CTs of lumbar spine, abdomen and pelvis. This underlines the broad applicability of WBLDCT in the management of MM patients.
Titel: |
Organ dose and total effective dose of whole-body CT in multiple myeloma patients.
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Autor/in / Beteiligte Person: | Hemke, R ; Yang, K ; Husseini, J ; Bredella, MA ; Simeone, FJ |
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Zeitschrift: | Skeletal radiology, Jg. 49 (2020-04-01), Heft 4, S. 549-554 |
Veröffentlichung: | Berlin : Springer Verlag ; <i>Original Publication</i>: Berlin, New York, Springer International., 2020 |
Medientyp: | academicJournal |
ISSN: | 1432-2161 (electronic) |
DOI: | 10.1007/s00256-019-03292-z |
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