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Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.

Methods and Results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration ( n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events.

Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.

Titel:	Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium.
Autor/in / Beteiligte Person:	Bahls, M ; Lorenz, MW ; Dörr, M ; Gao, L ; Kitagawa, K ; Tuomainen, TP ; Agewall, S ; Berenson, G ; Catapano, AL ; Norata, GD ; Bots, ML ; van Gilst W ; Asselbergs, FW ; Brouwers, FP ; Uthoff, H ; Sander, D ; Poppert, H ; Hecht Olsen, M ; Empana, JP ; Schminke, U ; Baldassarre, D ; Veglia, F ; Franco, OH ; Kavousi, M ; de Groot E ; Mathiesen, EB ; Grigore, L ; Polak, JF ; Rundek, T ; Stehouwer, CD ; Skilton, MR ; Hatzitolios, AI ; Savopoulos, C ; Ntaios, G ; Plichart, M ; McLachlan, S ; Lind, L ; Willeit, P ; Steinmetz, H ; Desvarieux, M ; Ikram, MA ; Johnsen, SH ; Schmidt, C ; Willeit, J ; Ducimetiere, P ; Price, JF ; Bergström, G ; Kauhanen, J ; Kiechl, S ; Sitzer, M ; Bickel, H ; Sacco, RL ; Hofman, A ; Völzke, H ; Thompson, SG
Link:	Full Text Finder (Volltext)
Zeitschrift:	European journal of preventive cardiology, Jg. 27 (2020-02-01), Heft 3, S. 234-243
Veröffentlichung:	2021- : [Oxford] : Oxford University Press ; <i>Original Publication</i>: London : Sage, 2020
Medientyp:	academicJournal
ISSN:	2047-4881 (electronic)
DOI:	10.1177/2047487319877078
Schlagwort:	Adult Aged Aged, 80 and over Female Humans Male Middle Aged Young Adult Biomarkers blood Carotid Intima-Media Thickness Cholesterol, HDL blood Cholesterol, LDL blood Disease Progression Heart Disease Risk Factors Myocardial Infarction epidemiology Predictive Value of Tests Prognosis Risk Assessment Stroke epidemiology Time Factors Blood Pressure Cardiovascular Diseases diagnosis Cardiovascular Diseases epidemiology Cardiovascular Diseases mortality Carotid Artery Diseases diagnostic imaging Carotid Artery Diseases epidemiology Carotid Artery Diseases mortality Cholesterol blood Dyslipidemias blood Dyslipidemias diagnosis Dyslipidemias epidemiology Dyslipidemias mortality Hypertension diagnosis Hypertension epidemiology Hypertension mortality Hypertension physiopathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: PROG-IMT Study Group Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Eur J Prev Cardiol] 2020 Feb; Vol. 27 (3), pp. 234-243. <i>Date of Electronic Publication: </i>2019 Oct 16. MeSH Terms: Blood Pressure* ; Cardiovascular Diseases* / diagnosis ; Cardiovascular Diseases* / epidemiology ; Cardiovascular Diseases* / mortality ; Carotid Artery Diseases* / diagnostic imaging ; Carotid Artery Diseases* / epidemiology ; Carotid Artery Diseases* / mortality ; Cholesterol* / blood ; Dyslipidemias* / blood ; Dyslipidemias* / diagnosis ; Dyslipidemias* / epidemiology ; Dyslipidemias* / mortality ; Hypertension* / diagnosis ; Hypertension* / epidemiology ; Hypertension* / mortality ; Hypertension* / physiopathology ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Biomarkers / blood ; Carotid Intima-Media Thickness ; Cholesterol, HDL / blood ; Cholesterol, LDL / blood ; Disease Progression ; Heart Disease Risk Factors ; Myocardial Infarction / epidemiology ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Stroke / epidemiology ; Time Factors Comments: Comment in: Eur J Prev Cardiol. 2020 Feb;27(3):231-233. (PMID: 31610703) References: J Hypertens. 1994 Oct;12(10):1183-9. (PMID: 7836735) ; Stroke. 2004 Oct;35(10):2248-52. (PMID: 15345795) ; Adv Ther. 2010 Apr;27(4):233-44. (PMID: 20437214) ; Am J Epidemiol. 2017 Oct 15;186(8):899-907. (PMID: 28549073) ; Eur Heart J. 2002 Jun;23(12):934-40. (PMID: 12069447) ; Circulation. 2018 Mar 20;137(12):e67-e492. (PMID: 29386200) ; Lancet. 2012 Jun 2;379(9831):2053-62. (PMID: 22541275) ; Int J Epidemiol. 1996 Dec;25(6):1172-81. (PMID: 9027521) ; Hypertension. 2000 Nov;36(5):801-7. (PMID: 11082146) ; Eur Heart J. 2018 Feb 14;39(7):508-579. (PMID: 29190377) ; JAMA. 2018 Nov 6;320(17):1793-1804. (PMID: 30398604) ; Control Clin Trials. 1986 Sep;7(3):177-88. (PMID: 3802833) ; Am J Epidemiol. 2005 Aug 1;162(3):267-78. (PMID: 15987729) ; J Clin Hypertens (Greenwich). 2003 Jan-Feb;5(1):47-52. (PMID: 12556653) ; J Am Coll Cardiol. 2000 Mar 1;35(3):673-80. (PMID: 10716470) ; Eur Heart J. 1997 Apr;18(4):566-71. (PMID: 9129884) ; Circulation. 2000 Sep 26;102(13):1536-41. (PMID: 11004145) ; Circulation. 2007 Jan 30;115(4):459-67. (PMID: 17242284) ; Int J Epidemiol. 2005 Feb;34(1):215-20. (PMID: 15333621) ; Circulation. 1995 Nov 1;92(9):2396-403. (PMID: 7586337) ; Stroke. 2006 Jan;37(1):87-92. (PMID: 16339465) ; Stroke. 1984 Sep-Oct;15(5):839-46. (PMID: 6474535) ; Circulation. 2001 Feb 27;103(8):1064-70. (PMID: 11222467) ; N Engl J Med. 1999 Jan 7;340(1):14-22. (PMID: 9878640) ; Stroke. 2006 Jun;37(6):1558-61. (PMID: 16675737) ; Am J Cardiol. 2008 Dec 15;102(12):1663-7. (PMID: 19064020) ; J Am Coll Cardiol. 2009 Dec 29;55(1):35-41. (PMID: 20117361) ; Am Heart J. 2010 May;159(5):730-736.e2. (PMID: 20435179) ; Psychol Bull. 1967 Nov;68(5):304-5. (PMID: 6062585) ; Stroke. 2010 Oct;41(10):2375-7. (PMID: 20814002) ; Arterioscler Thromb Vasc Biol. 1997 Mar;17(3):513-9. (PMID: 9102170) ; Circulation. 2012 Jan 3;125(1):37-44. (PMID: 22184621) ; Am J Epidemiol. 1997 Sep 15;146(6):483-94. (PMID: 9290509) ; Stroke. 2000 Mar;31(3):574-81. (PMID: 10700488) ; Circ Cardiovasc Imaging. 2018 Jan;11(1):e006209. (PMID: 29305347) ; BMJ. 2003 Sep 6;327(7414):557-60. (PMID: 12958120) Grant Information: K24 NS062737 United States NS NINDS NIH HHS; HHSN268201200036C United States HL NHLBI NIH HHS; R37 NS029993 United States NS NINDS NIH HHS Contributed Indexing: Keywords: CVD biomarker; Risk factors; risk factor progression Substance Nomenclature: 0 (Biomarkers) ; 97C5T2UQ7J (Cholesterol) ; 0 (Cholesterol, HDL) ; 0 (Cholesterol, LDL) Entry Date(s): Date Created: 20191018 Date Completed: 20201221 Latest Revision: 20240404 Update Code: 20240405 PubMed Central ID: PMC7008553

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Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium.