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Rationale and Objectives: To determine the upgrade rate of noncalcified ductal carcinoma in situ (DCIS) and features that are associated with risk of upgrade to invasive disease at surgery.

Materials and Methods: A retrospective review was conducted of consecutive women who were diagnosed with noncalcified DCIS from January 2007 to December 2016. Patient demographics, imaging findings, biopsy pathology results, and surgical outcomes were reviewed. The unpaired t test, chi-square test, and Fisher's exact test were used to compare features between the cases of DCIS that did and did not upgrade to invasive carcinoma at surgery.

Results: Over a 10-year period, 78 women (mean age 62 years, range 30-88 years) were diagnosed with noncalcified DCIS. Two-thirds (67.9%, 53/78) of cases were detected on screening mammography, and 15.4% (12/78) of diagnoses were made after presentation with an area of palpable concern. The most common mammographic presentations of noncalcified DCIS were mass (51.3%, 40/78) and asymmetry (30.8%, 24/78). Seventeen cases (21.8%, 17/78) were upgraded to invasive ductal carcinoma (IDC) at surgery. Features associated with upgrade risk included older patient age (68.1 versus 60.3 years, OR 1.08, p < 0.01) and family history of breast cancer in a first-degree relative (41.2% [7/17] versus 16.4% [10/61], OR 3.57, p = 0.03).

Conclusion: In our study cohort, the upgrade rate of noncalcified DCIS to IDC at surgery is 21.8%. Upgrade risk is associated with older patient age and family history of breast cancer in a first-degree relative.

Titel:	Noncalcified Ductal Carcinoma In Situ (DCIS): Rate and Predictors of Upgrade to Invasive Carcinoma.
Autor/in / Beteiligte Person:	Lamb, LR ; Kim, G ; Oseni, TO ; Bahl, M
Zeitschrift:	Academic radiology, Jg. 28 (2021-03-01), Heft 3, S. e71-e76
Veröffentlichung:	Reston Va : Association Of University Radiologists ; <i>Original Publication</i>: Reston, VA : Association of University Radiologists, c1994-, 2021
Medientyp:	academicJournal
ISSN:	1878-4046 (electronic)
DOI:	10.1016/j.acra.2020.02.011
Schlagwort:	Adult Aged Aged, 80 and over Early Detection of Cancer Female Humans Mammography Middle Aged Retrospective Studies Breast Neoplasms diagnostic imaging Breast Neoplasms epidemiology Carcinoma in Situ Carcinoma, Ductal, Breast diagnostic imaging Carcinoma, Ductal, Breast epidemiology Carcinoma, Intraductal, Noninfiltrating diagnostic imaging Carcinoma, Intraductal, Noninfiltrating epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Acad Radiol] 2021 Mar; Vol. 28 (3), pp. e71-e76. <i>Date of Electronic Publication: </i>2020 Mar 26. MeSH Terms: Breast Neoplasms* / diagnostic imaging ; Breast Neoplasms* / epidemiology ; Carcinoma in Situ* ; Carcinoma, Ductal, Breast* / diagnostic imaging ; Carcinoma, Ductal, Breast* / epidemiology ; Carcinoma, Intraductal, Noninfiltrating* / diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating* / epidemiology ; Adult ; Aged ; Aged, 80 and over ; Early Detection of Cancer ; Female ; Humans ; Mammography ; Middle Aged ; Retrospective Studies Contributed Indexing: Keywords: Breast cancer; Ductal carcinoma in situ; Invasive ductal carcinoma Entry Date(s): Date Created: 20200331 Date Completed: 20210316 Latest Revision: 20210316 Update Code: 20240513

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Noncalcified Ductal Carcinoma In Situ (DCIS): Rate and Predictors of Upgrade to Invasive Carcinoma.