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Duchenne muscular dystrophy (DMD) is a condition caused by an amendment to the X chromosome, inherited as a recessive trait, and affects 1:3500 live births, especially males. Low-intensity exercise is known to decrease certain parameters associated with muscular degeneration in animal models of progressive muscular dystrophies. In the present study, 28-day-old male mdx and wild-type (wild) mice were used. The animals were subjected to a low-intensity physical exercise protocol for 8 weeks. It was found that this protocol was able to reduce oxidative stress in muscle tissue and in most of the CNS structures analyzed, with a significant increase in antioxidant activity in all analyzed structures. It is thus possible to infer that this exercise protocol was able to reduce oxidative stress and improve the energy metabolism in brain tissue and in the gastrocnemius muscle of animals with DMD.

Titel:	Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy.
Autor/in / Beteiligte Person:	Hoepers, A ; Alberti, A ; Freiberger, V ; Ventura, L ; Grigollo, LR ; Andreu, CS ; da Silva BB ; Martins, DF ; Junior, RJN ; Streck, EL ; Comim, CM
Link:	View record at Springer (Volltext)
Zeitschrift:	Journal of molecular neuroscience : MN, Jg. 70 (2020-10-01), Heft 10, S. 1552-1564
Veröffentlichung:	Totowa, NJ : Humana Press ; <i>Original Publication</i>: Boston : Birkhäuser [i.e. Cambridge, MA : Birkhäuser Boston, c1989-, 2020
Medientyp:	academicJournal
ISSN:	1559-1166 (electronic)
DOI:	10.1007/s12031-020-01565-0
Schlagwort:	Animals Male Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle, Skeletal metabolism Muscle, Skeletal physiopathology Oxidative Stress Exercise Therapy methods Muscular Dystrophy, Duchenne therapy Physical Conditioning, Animal methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Mol Neurosci] 2020 Oct; Vol. 70 (10), pp. 1552-1564. <i>Date of Electronic Publication: </i>2020 Jun 08. MeSH Terms: Exercise Therapy / methods ; Muscular Dystrophy, Duchenne / therapy ; Physical Conditioning, Animal / *methods ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred mdx ; Muscle, Skeletal / metabolism ; Muscle, Skeletal / physiopathology ; Oxidative Stress References: Abou-Samra M, Lecompte S, Schakman O, Noel L, Many MC, Gailly P et al (2015) Involvement of adiponectin in the pathogenesis of dystrophinopathy. Skelet Muscle 7(5):25. (PMID: 10.1186/s13395-015-0051-9) ; Alemdaroğlu Đ, Karaduman A, Yilmaz ÖT, Topaloğlu H (2015) Different types of upper extremity exercise training in Duchenne muscular dystrophy: effects on functional performance, strength, endurance, and ambulation. Muscle Nerve 51(5):697–705. 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Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy.