| Sonstiges: |
- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Language: English
- [Nat Commun] 2020 Sep 14; Vol. 11 (1), pp. 4596. <i>Date of Electronic Publication: </i>2020 Sep 14.
- MeSH Terms: Caspase 8 / *metabolism ; Inflammation / *pathology ; Malaria, Cerebral / *enzymology ; Animals ; Brain / pathology ; Caspase 1 / metabolism ; Dendritic Cells / metabolism ; Enzyme Activation ; Extracellular Matrix / metabolism ; Gene Expression Regulation ; Humans ; Interferon-gamma / metabolism ; Interleukin-1beta / metabolism ; Lipopolysaccharides ; Malaria, Cerebral / genetics ; Mice, Inbred C57BL ; Monocytes / metabolism ; Plasmodium chabaudi / physiology ; Spleen / metabolism ; Toll-Like Receptors / metabolism
- Comments: Erratum in: Nat Commun. 2020 Nov 3;11(1):5673. (PMID: 33144583)
- References: Gazzinelli, R. T., Kalantari, P., Fitzgerald, K. A. & Golenbock, D. T. Innate sensing of malaria parasites. Nat. Rev. Immunol. 14, 744–757 (2014). (PMID: 25324127) ; Parroche, P. et al. Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc. Natl Acad. Sci. USA 104, 1919–1924 (2007). ; Krishnegowda, G. et al. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J. Biol. Chem. 280, 8606–8616 (2005). (PMID: 15623512) ; Dostert, C. et al. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS ONE 4, e6510 (2009). (PMID: 196527102714977) ; Shio, M. T. et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 5, e1000559 (2009). (PMID: 19696895) ; Kalantari, P. et al. Dual engagement of the NLRP3 and AIM2 inflammasomes by Plasmodium-derived hemozoin and DNA during malaria. Cell Rep. 6, 196–210 (2014). (PMID: 243887514105362) ; Orengo, J. M. et al. Plasmodium-induced inflammation by uric acid. PLoS Pathog. 4, e1000013 (2008). (PMID: 183694652267007) ; Gallego-Marin, C. et al. Cyclic GMP-AMP synthase is the cytosolic sensor of Plasmodium falciparum genomic DNA and activates type I IFN in malaria. J. Immunol. 200, 768–774 (2018). (PMID: 29212905) ; Cunnington, A. J., de Souza, J. B., Walther, M. & Riley, E. M. Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization. Nat. Med. 18, 120–127 (2012). ; Lacerda, M. V. et al. Postmortem characterization of patients with clinical diagnosis of Plasmodium vivax malaria: to what extent does this parasite kill? Clin. Infect. Dis. 55, e67–e74 (2012). ; Scott, J. A. et al. Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study. Lancet 378, 1316–1323 (2011). (PMID: 219032513192903) ; Were, T. et al. Bacteremia in Kenyan children presenting with malaria. J. Clin. Microbiol. 49, 671–676 (2011). (PMID: 211067893043473) ; Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10, 417–426 (2002). ; Bauernfeind, F. G. et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787–791 (2009). (PMID: 195708222824855) ; Harder, J. et al. Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J. Immunol. 183, 5823–5829 (2009). (PMID: 198122052765568) ; Latz, E., Xiao, T. S. & Stutz, A. Activation and regulation of the inflammasomes. Nat. Rev. Immunol. 13, 397–411 (2013). ; Lamkanfi, M. & Dixit, V. M. Modulation of inflammasome pathways by bacterial and viral pathogens. J. Immunol. 187, 597–602 (2011). ; Ataide, M. A. et al. Malaria-Induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog. 10, e1003885 (2014). (PMID: 244539773894209) ; Hirako, I. C. et al. DNA-containing immunocomplexes promote inflammasome assembly and release of pyrogenic cytokines by CD14+ CD16+ CD64high CD32low inflammatory monocytes from malaria patients. mBio 6, e01605–e01615 (2015). (PMID: 265786794659466) ; Casson, C. N. et al. Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. PLoS Pathog. 9, e1003400 (2013). (PMID: 237620263675167) ; Kayagaki, N. et al. Non-canonical inflammasome activation targets caspase-11. Nature 479, 117–121 (2011). (PMID: 22002608) ; Casson, C. N. et al. Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens. Proc. Natl Acad. Sci. USA 112, 6688–6693 (2015). (PMID: 25964352) ; Kayagaki, N. et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666–671 (2015). (PMID: 26375259) ; Liu, X. et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535, 153–158 (2016). (PMID: 273839865539988) ; Aglietti, R. A. et al. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc. Natl Acad. Sci. USA 113, 7858–7863 (2016). (PMID: 27339137) ; Sborgi, L. et al. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J. 35, 1766–1778 (2016). (PMID: 274181905010048) ; Ketelut-Carneiro, N., Ghosh, S., Levitz, S. M., Fitzgerald, K. A. & da Silva, J. S. A dectin-1-caspase-8 pathway licenses canonical caspase-1 inflammasome activation and interleukin-1beta release in response to a pathogenic fungus. J. Infect. Dis. 217, 329–339 (2018). (PMID: 29099934) ; Man, S. M. et al. Salmonella infection induces recruitment of caspase-8 to the inflammasome to modulate IL-1beta production. J. Immunol. 191, 5239–5246 (2013). (PMID: 24123685) ; Weng, D. et al. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc. Natl Acad. Sci. USA 111, 7391–7396 (2014). (PMID: 24799678) ; Orning, P. et al. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science 362, 1064–1069 (2018). (PMID: 65221296522129) ; Franklin, B. S. et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc. Natl Acad. Sci. USA 108, 3689–3694 (2011). ; Franklin, B. S. et al. Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc. Natl Acad. Sci. USA 106, 5789–5794 (2009). ; Broz, P., von Moltke, J., Jones, J. W., Vance, R. E. & Monack, D. M. Differential requirement for caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 8, 471–483 (2010). (PMID: 2114746221147462) ; Hagar, J. A., Powell, D. A., Aachoui, Y., Ernst, R. K. & Miao, E. A. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 341, 1250–1253 (2013). (PMID: 2403101824031018) ; Kayagaki, N. et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341, 1246–1249 (2013). (PMID: 2388787323887873) ; Rathinam, V. A. et al. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell 150, 606–619 (2012). (PMID: 2281953922819539) ; Gurung, P. et al. Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-beta (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens. J. Biol. Chem. 287, 34474–34483 (2012). (PMID: 2289881622898816) ; Wu, X., Gowda, N. M., Kumar, S. & Gowda, D. C. Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses. J. Immunol. 184, 4338–4348 (2010). (PMID: 2023169320231693) ; Sharma, S. et al. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity 35, 194–207 (2011). (PMID: 31629983162998) ; Wu, J. et al. Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality. Proc. Natl Acad. Sci. USA 111, E511–E520 (2014). (PMID: 24474800) ; Aachoui, Y. et al. Canonical inflammasomes drive IFN-gamma to prime caspase-11 in defense against a cytosol-invasive bacterium. Cell Host Microbe 18, 320–332 (2015). (PMID: 263209994567510) ; Chimma, P. et al. A distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated Plasmodium falciparum malaria. PLoS Pathog. 5, e1000631 (2009). (PMID: 198514532759288) ; Antonelli, L. R. V. et al. The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria. PLoS Pathog. 10, e1004393 (2014). ; Hirako, I. C. et al. Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria. Nat. Commun. 7, 13277 (2016). (PMID: 278080895097164) ; Shi, J. et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660–665 (2015). (PMID: 26375003) ; Monie, T. P. & Bryant, C. E. Caspase-8 functions as a key mediator of inflammation and pro-IL-1beta processing via both canonical and non-canonical pathways. Immunol. Rev. 265, 181–193 (2015). (PMID: 25879293) ; Grau, G. E. et al. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237, 1210–1212 (1987). (PMID: 3306918) ; Kwiatkowski, D. et al. Anti-TNF therapy inhibits fever in cerebral malaria. Q J. Med. 86, 91–98 (1993). (PMID: 8329024) ; Galvao-Filho, B. et al. The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4. Mucosal Immunol. 12, 312–322 (2018). (PMID: 303376506375779) ; Reimer, T. et al. Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome. Eur. J. Immunol. 40, 764–769 (2010). (PMID: 199501872837133) ; Kordes, M., Matuschewski, K. & Hafalla, J. C. Caspase-1 activation of interleukin-1beta (IL-1beta) and IL-18 is dispensable for induction of experimental cerebral malaria. Infect. Immun. 79, 3633–3641 (2011). (PMID: 217089933165484) ; Rosenthal, P. J. & Meshnick, S. R. Hemoglobin catabolism and iron utilization by malaria parasites. Mol. Biochem. Parasitol. 83, 131–139 (1996). (PMID: 9027746) ; Zhou, J., Ludlow, L. E., Hasang, W., Rogerson, S. J. & Jaworowski, A. Opsonization of malaria-infected erythrocytes activates the inflammasome and enhances inflammatory cytokine secretion by human macrophages. Malar. J. 11, 343 (2012). (PMID: 230465483528456) ; Gross, O. et al. Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36, 388–400 (2012). ; Py, B. F. et al. Caspase-11 controls interleukin-1beta release through degradation of TRPC1. Cell Rep. 6, 1122–1128 (2014). (PMID: 246309894239700) ; Ruhl, S. & Broz, P. Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux. Eur. J. Immunol. 45, 2927–2936 (2015). ; Schmid-Burgk, J. L. et al. Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells. Eur. J. Immunol. 45, 2911–2917 (2015). ; Rivers-Auty, J. & Brough, D. Potassium efflux fires the canon: potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. Eur. J. Immunol. 45, 2758–2761 (2015). ; Yang, J., Zhao, Y. & Shao, F. Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity. Curr. Opin. Immunol. 32, 78–83 (2015). ; Gowda, N. M., Wu, X. & Gowda, D. C. TLR9 and MyD88 are crucial for the development of protective immunity to malaria. J. Immunol. 188, 5073–5085 (2012). (PMID: 225169593345097) ; Yu, X. et al. Cross-regulation of two type I interferon signaling pathways in plasmacytoid dendritic cells controls anti-malaria immunity and host mortality. Immunity 45, 1093–1107 (2016). (PMID: 277935947128466) ; Franklin, B. S. et al. MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria. Microbes Infect. 9, 881–890 (2007). (PMID: 17537666) ; Wang, S. et al. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92, 501–509 (1998). (PMID: 9491891) ; Stevenson, M. M., Tam, M. F., Belosevic, M., van der Meide, P. H. & Podoba, J. E. Role of endogenous gamma interferon in host response to infection with blood-stage Plasmodium chabaudi AS. Infect. Immun. 58, 3225–3232 (1990). (PMID: 2119342313643) ; Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114–2120 (2014). (PMID: 246954044103590) ; Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15–21 (2013). (PMID: 2310488623104886) ; Trapnell, C. et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and cufflinks. Nat. Protoc. 7, 562–578 (2012). (PMID: 223830363334321) ; Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498–2504 (2003). (PMID: 14597658403769)
- Grant Information: R01 AI079293 United States AI NIAID NIH HHS; U19 AI089681 United States AI NIAID NIH HHS; R21 AI150546 United States AI NIAID NIH HHS; R03 TW009007 United States TW FIC NIH HHS; R01 NS098747 United States NS NINDS NIH HHS
- Molecular Sequence: figshare 10.6084/m9.figshare.12751163.v1
- Substance Nomenclature: 0 (Interleukin-1beta) ; 0 (Lipopolysaccharides) ; 0 (Toll-Like Receptors) ; 82115-62-6 (Interferon-gamma) ; EC 3.4.22.- (Caspase 8) ; EC 3.4.22.36 (Caspase 1)
- Entry Date(s): Date Created: 20200915 Date Completed: 20200923 Latest Revision: 20220716
- Update Code: 20240513
- PubMed Central ID: PMC7490701
|
