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In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3 years. Forty-nine GC events were observed in 47 patients. MLH1 (n = 21) and MSH2 (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early-stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; P = .0231). Thirty-two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28-66). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30.

Titel:	Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome.
Autor/in / Beteiligte Person:	Ladigan-Badura, S ; Vangala, DB ; Engel, C ; Bucksch, K ; Hueneburg, R ; Perne, C ; Nattermann, J ; Steinke-Lange, V ; Rahner, N ; Schackert, HK ; Weitz, J ; Kloor, M ; Kuhlkamp, J ; Nguyen, HP ; Moeslein, G ; Strassburg, C ; Morak, M ; Holinski-Feder, E ; Buettner, R ; Aretz, S ; Loeffler, M ; Schmiegel, W ; Pox, C ; Schulmann, K
Link:	Full Text Finder (Volltext)
Zeitschrift:	International journal of cancer, Jg. 148 (2021), Heft 1, S. 106-114
Veröffentlichung:	1995- : New York, NY : Wiley-Liss ; <i>Original Publication</i>: 1966-1984 : Genève : International Union Against Cancer, 2021
Medientyp:	academicJournal
ISSN:	1097-0215 (electronic)
DOI:	10.1002/ijc.33294
Schlagwort:	Adult Age Factors Aged Colorectal Neoplasms, Hereditary Nonpolyposis genetics Early Detection of Cancer standards Early Detection of Cancer statistics & numerical data Evaluation Studies as Topic Gastric Mucosa diagnostic imaging Gastric Mucosa pathology Gastroscopy standards Genetic Predisposition to Disease Germany epidemiology Humans Male Middle Aged MutL Protein Homolog 1 genetics MutS Homolog 2 Protein genetics Mutation Neoplasm Staging Patient Compliance statistics & numerical data Practice Guidelines as Topic Prospective Studies Stomach Neoplasms epidemiology Stomach Neoplasms genetics Stomach Neoplasms pathology Colorectal Neoplasms, Hereditary Nonpolyposis complications Early Detection of Cancer methods Gastroscopy statistics & numerical data Stomach Neoplasms diagnosis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: German Consortium for Familial Intestinal Cancer Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Language: English [Int J Cancer] 2021 Jan 01; Vol. 148 (1), pp. 106-114. <i>Date of Electronic Publication: </i>2020 Oct 13. MeSH Terms: Colorectal Neoplasms, Hereditary Nonpolyposis / complications ; Early Detection of Cancer / methods ; Gastroscopy / statistics & numerical data ; Stomach Neoplasms / diagnosis ; Adult ; Age Factors ; Aged ; Colorectal Neoplasms, Hereditary Nonpolyposis / genetics ; Early Detection of Cancer / standards ; Early Detection of Cancer / statistics & numerical data ; Evaluation Studies as Topic ; Gastric Mucosa / diagnostic imaging ; Gastric Mucosa / pathology ; Gastroscopy / standards ; Genetic Predisposition to Disease ; Germany / epidemiology ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1 / genetics ; MutS Homolog 2 Protein / genetics ; Mutation ; Neoplasm Staging ; Patient Compliance / statistics & numerical data ; Practice Guidelines as Topic ; Prospective Studies ; Stomach Neoplasms / epidemiology ; Stomach Neoplasms / genetics ; Stomach Neoplasms / pathology References: Hampel H, Stephens JA, Pukkala E, et al. 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Contributed Indexing: Keywords: HNPCC; Lynch syndrome; gastric cancer; screening; surveillance Substance Nomenclature: 0 (MLH1 protein, human) ; EC 3.6.1.3 (MSH2 protein, human) ; EC 3.6.1.3 (MutL Protein Homolog 1) ; EC 3.6.1.3 (MutS Homolog 2 Protein) Entry Date(s): Date Created: 20200915 Date Completed: 20210610 Latest Revision: 20210610 Update Code: 20240513

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Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome.