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Objective: To investigate the effects of aerobic exercise and resveratrol on janus kinase 2(JAK2) and transforming growth factor-β1(TGF-β1) in renal tissue of type 2 diabetes rats and its mechanism. Methods: The model of type 2 diabetic rats was established through SD rats fed high-fat diet for 5 weeks together with intraperitoneal infecting after a low dose of STZ. The rats were randomly divided into diabetic control group(DC), diabetic exercise group(DE), diabetic resveratrol group(DR), diabetic exercise and resveratrol group(DER), normal control group(NC), 12 rats in each group. Exercise-related groups performed 8 weeks treadmill exercise (20 m/min, 60 min/day). Resveratrol was administered to drug-related groups for 8 weeks (45 mg/kg, 7 day/week). Eight weeks later, we examined blood glucose concentrations, 24 h microalbuminuria(UA), serum creatinine(Scr), blood urea nitrogen(BUN), and the expressions of TGF-β1, janus kinase 2(JAK2) and JAK2 mRNA in renal tissue. Results: After eight weeks of intervention, compared with NC group, the concentrations blood glucose, 24 h UA, Scr, BUN, the expressions of TGF-β1, JAK2 and JAK2 mRNA were increased significantly in DC group(P＜0.05). Compared with DC group, the concentrations of blood glucose, 24 h UA, Scr, BUN, the expressions of TGF-β1, JAK2 and JAK2 mRNA were decreased significantly in DE group, DR group and DER group(P＜0.05). Conclusion: Exercise, resveratrol and combined intervention may decrease the expressions of JAK2 mRNA, JAK2 and TGF-β1, which further attenuate renal injury for type 2 diabetes. The renal protective effect produced by exercise and resveratrol combined intervention is better than that produced by exercise or resveratrol intervention alone.

Titel:	[Effects of aerobic exercise and resveratrol on the expressions of JAK2 and TGF-β1 in renal tissue of type 2 diabetes rats].
Autor/in / Beteiligte Person:	Sun, XJ ; Feng, WL ; Hou, N ; Li, N ; Jiang, WL
Zeitschrift:	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, Jg. 36 (2020-05-01), Heft 3, S. 202-206
Veröffentlichung:	Tianjin : Zhongguo ying yong sheng li xue za zhi bian ji bu ; <i>Original Publication</i>: Beijing Shi : Zhongguo ying yong sheng li xue za zhi bian ji bu,, 2020
Medientyp:	academicJournal
ISSN:	1000-6834 (print)
DOI:	10.12047/j.cjap.5918.2020.045
Schlagwort:	Acute Kidney Injury etiology Acute Kidney Injury prevention & control Animals Diabetes Mellitus, Experimental complications Diabetes Mellitus, Experimental drug therapy Rats Rats, Sprague-Dawley Diabetes Mellitus, Type 2 complications Diabetes Mellitus, Type 2 drug therapy Gene Expression Regulation drug effects Janus Kinase 2 metabolism Kidney drug effects Kidney enzymology Physical Conditioning, Animal physiology Resveratrol pharmacology Transforming Growth Factor beta1 metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Publication Type: Journal Article Language: Chinese [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2020 May; Vol. 36 (3), pp. 202-206. MeSH Terms: Diabetes Mellitus, Type 2* / complications ; Diabetes Mellitus, Type 2* / drug therapy ; Gene Expression Regulation* / drug effects ; Janus Kinase 2* / metabolism ; Kidney* / drug effects ; Kidney* / enzymology ; Physical Conditioning, Animal* / physiology ; Resveratrol* / pharmacology ; Transforming Growth Factor beta1* / metabolism ; Acute Kidney Injury / etiology ; Acute Kidney Injury / prevention & control ; Animals ; Diabetes Mellitus, Experimental / complications ; Diabetes Mellitus, Experimental / drug therapy ; Rats ; Rats, Sprague-Dawley Contributed Indexing: Keywords: rat; JAK2; TGF-β1; aerobic exercise; resveratrol; type 2 diabetes ; Local Abstract: [Publisher, Chinese] 目的: 研究有氧运动和白藜芦醇对2型糖尿病大鼠肾脏Janus激酶2(JAK2)及转化生长因子-β1(TGF-β1)表达的影响,探讨运动与白藜芦醇改善糖尿病肾损伤的可能作用机制。方法: SD大鼠经5周高糖高脂饲料喂养加腹腔注射链脲佐菌素(STZ)建立糖尿病模型后,将糖尿病大鼠随机分为糖尿病安静组(DC组),糖尿病运动组(DE组),糖尿病药物组(DR组)和糖尿病运动药物组(DER组),每组各12只,另设正常对照组(NC组)。运动组大鼠进行8周的有氧运动(跑速为20 m/min),每天运动60 min,每周运动6 d;药物组大鼠进行8周的白藜芦醇灌胃(每天45 mg/kg,7天/周)。8周末,检测血糖、24 h尿白蛋白(24 h UA)、血肌酐(Scr)、血尿素氮(BUN)的变化;采用荧光定量PCR检测肾脏JAK2 mRNA的表达,免疫组织化学法和Western blot法检测肾脏JAK2和TGF-β1的表达。结果: 8周干预后,与NC组相比, DC组血糖浓度、24 h UA、Scr、BUN均显著上升(P＜0.05),肾组织病理损伤加重,肾组织TGF-β1、JAK2和JAK2 mRNA的表达均明显增加(P＜0.05)。与DC组相比,DE、DR和DER组血糖浓度、24 h UA、Scr、BUN均显著下降(P＜0.05),肾组织病理损伤减轻,肾组织TGF-β1、JAK2和JAK2 mRNA的表达均明显减少(P＜0.05),且DER组的降低更显著,与DE、DR组相比差异有显著性(P＜0.05)。结论: 有氧运动、白藜芦醇及联合干预可能通过下调肾脏JAK2 mRNA表达,抑制JAK2蛋白的合成,使TGF-β1表达减少,从而改善糖尿病大鼠肾脏损伤的病理性变化。有氧运动联合白藜芦醇干预减轻肾脏病理损伤的效果优于单一的有氧运动或白藜芦醇干预。. Substance Nomenclature: 0 (Transforming Growth Factor beta1) ; EC 2.7.10.2 (Janus Kinase 2) ; Q369O8926L (Resveratrol) Entry Date(s): Date Created: 20200927 Date Completed: 20201109 Latest Revision: 20201109 Update Code: 20240513

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[Effects of aerobic exercise and resveratrol on the expressions of JAK2 and TGF-β1 in renal tissue of type 2 diabetes rats].