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Context: Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown.

Objective: To investigate how SAT mitochondria change following diet-induced and bariatric surgery-induced weight-loss interventions in 4 independent weight-loss studies.

Methods: The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up.

Results: Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: -8.7 following LCD, -4.4 following weight maintenance; CRYO: IPA z-score: -5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001).

Conclusions: Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.

Titel:	Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery.
Autor/in / Beteiligte Person:	van der Kolk BW ; Muniandy, M ; Kaminska, D ; Alvarez, M ; Ko, A ; Miao, Z ; Valsesia, A ; Langin, D ; Vaittinen, M ; Pääkkönen, M ; Jokinen, R ; Kaye, S ; Heinonen, S ; Virtanen, KA ; Andersson, DP ; Männistö, V ; Saris, WH ; Astrup, A ; Rydén, M ; Blaak, EE ; Pajukanta, P ; Pihlajamäki, J ; Pietiläinen, KH
Link:	Full Text Finder (Volltext)
Zeitschrift:	The Journal of clinical endocrinology and metabolism, Jg. 106 (2021-04-23), Heft 5, S. 1312-1324
Veröffentlichung:	2017- : New York : Oxford University Press ; <i>Original Publication</i>: Springfield, Ill. : Charles C. Thomas, 2021
Medientyp:	academicJournal
ISSN:	1945-7197 (electronic)
DOI:	10.1210/clinem/dgab072
Schlagwort:	Adult Bariatric Surgery Diet, Reducing Female Gene Expression Gene Expression Profiling Humans Male Metabolic Networks and Pathways genetics Middle Aged Mitochondria genetics Mitochondria metabolism Obesity, Morbid diet therapy Obesity, Morbid genetics Obesity, Morbid surgery Retrospective Studies Weight Loss genetics Weight Reduction Programs Adipose Tissue metabolism Genes, Mitochondrial genetics Weight Loss physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [J Clin Endocrinol Metab] 2021 Apr 23; Vol. 106 (5), pp. 1312-1324. MeSH Terms: Adipose Tissue / metabolism ; Genes, Mitochondrial / genetics ; Weight Loss / *physiology ; Adult ; Bariatric Surgery ; Diet, Reducing ; Female ; Gene Expression ; Gene Expression Profiling ; Humans ; Male ; Metabolic Networks and Pathways / genetics ; Middle Aged ; Mitochondria / genetics ; Mitochondria / metabolism ; Obesity, Morbid / diet therapy ; Obesity, Morbid / genetics ; Obesity, Morbid / surgery ; Retrospective Studies ; Weight Loss / genetics ; Weight Reduction Programs References: Sci Rep. 2018 May 22;8(1):8177. (PMID: 29784999) ; J Intern Med. 2020 Aug;288(2):219-233. (PMID: 32406570) ; Am J Clin Nutr. 2011 Dec;94(6):1399-409. (PMID: 22030226) ; Nature. 2006 Dec 14;444(7121):875-80. (PMID: 17167476) ; Obes Surg. 2015 Dec;25(12):2376-85. (PMID: 25975200) ; Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792) ; Br J Nutr. 2013 May 28;109(10):1910-6. (PMID: 22935366) ; Int J Obes (Lond). 2018 Apr;42(4):817-825. (PMID: 29203860) ; Nucleic Acids Res. 2016 Jan 4;44(D1):D1258-61. (PMID: 26432830) ; Sci Rep. 2015 Oct 05;5:14841. (PMID: 26434764) ; Am J Clin Nutr. 2010 Oct;92(4):975-84. (PMID: 20739421) ; Obesity (Silver Spring). 2015 Oct;23(10):2022-9. (PMID: 26337597) ; Diabetes. 2019 Dec;68(12):2247-2258. (PMID: 31492661) ; Am J Clin Nutr. 2001 Nov;74(5):579-84. (PMID: 11684524) ; Diabetologia. 2014 Jan;57(1):167-76. (PMID: 24100782) ; Int J Obes (Lond). 2017 Aug;41(8):1176-1184. (PMID: 28439093) ; Acta Physiol (Oxf). 2020 Jan;228(1):e13298. (PMID: 31077538) ; Int J Obes (Lond). 2017 May;41(5):722-728. (PMID: 28179648) ; J Clin Endocrinol Metab. 2021 Apr 23;106(5):1312-1324. (PMID: 33560372) ; Am J Clin Nutr. 2017 Sep;106(3):736-746. (PMID: 28793995) ; Surg Obes Relat Dis. 2018 May;14(5):708-714. (PMID: 29776493) ; Int J Obes (Lond). 2017 Feb;41(2):309-316. (PMID: 27840413) ; N Engl J Med. 2010 Nov 25;363(22):2102-13. (PMID: 21105792) ; Metabolism. 2010 Jun;59(6):866-72. (PMID: 20015521) ; Cell Metab. 2015 Aug 4;22(2):228-38. (PMID: 26244932) ; Int J Obes Relat Metab Disord. 1997 Mar;21 Suppl 1:S5-9. (PMID: 9130034) ; Nature. 2006 Dec 14;444(7121):840-6. (PMID: 17167471) ; Diabetologia. 2016 May;59(5):945-53. (PMID: 26983924) ; Adv Nutr. 2019 Jul 1;10(4):673-684. (PMID: 31075175) ; Genome Biol. 2008 Jan 21;9(1):R14. (PMID: 18208606) ; Diabetes. 2015 Sep;64(9):3135-45. (PMID: 25972572) ; Diabetologia. 2017 Jan;60(1):169-181. (PMID: 27734103) ; Clin Nutr. 2017 Jun;36(3):861-868. (PMID: 27188262) ; J Clin Endocrinol Metab. 2016 Mar;101(3):1263-73. (PMID: 26760174) ; J Clin Endocrinol Metab. 2020 Mar 1;105(3):. (PMID: 31917447) ; Diabetes Care. 2017 Jan;40(1):77-84. (PMID: 27852664) ; Sci Rep. 2019 Mar 12;9(1):4202. (PMID: 30862933) Grant Information: P01 HL028481 United States HL NHLBI NIH HHS; United States HHMI Howard Hughes Medical Institute; T32 HG002536 United States HG NHGRI NIH HHS; U01 DK105561 United States DK NIDDK NIH HHS; R01 HL095056 United States HL NHLBI NIH HHS Contributed Indexing: Keywords: adipose tissue; bariatric surgery; diet-induced; mitochondria; transcriptomics; weight loss Molecular Sequence: ClinicalTrials.gov NCT00390637; NCT01312090; NCT01785134 Entry Date(s): Date Created: 20210209 Date Completed: 20210927 Latest Revision: 20240403 Update Code: 20240403 PubMed Central ID: PMC8063261

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Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery.