Einzeltreffer — DigiBib

Objective: To compare of the clinical efficacy of frozen amniotic membrane transplantation (AMT) and lamellar keratoplasty (LKP) in the treatment of Mooren ulcer.

Method: Forty patients (42 eyes) with Mooren's ulcer in our hospital from January 2010 to January 2019 were divided into frozen AMT group (20 eyes) and LKP group (22 eyes). Comparative observation of post-operative best corrected visual acuity (BCVA), corneal epithelial healing time, corneal epithelialization time, ulcer healing, corneal transparency, corneal graft transparency, neovascularization and original disease recurrence were observed.

Results: The average BCVA at post-operative 6 and 12 months in LKP group were significantly lower than AMT group (P < 0.05). The ulcer healing rates in LKP group (63.6) were significantly higher than AMT group (30) (P < 0.05). The corneal epithelialization time of LKP group were 9.55 ± 1.26 days. The corneal epithelial healing time of AMT group were 13.50 ± 2.21 days. Nine cases were corneal graft transparency grade 0, and 13 cases were grade I. Three eyes in AMT group were corneal transparency grade 0, 7 were grade I and 10 were grade II. Corneal neovascularization were observed in 3 eyes in AMT group and 4 eyes in LKP group. The original disease recurrence rates in LKP group (50) were significantly higher than AMT group (20) (P < 0.05). Four cases of primary corneal transplantation failure were observed in LKP group.

Conclusion: Lamellar keratoplasty group obtained significantly better BCVA during follow-up and faster healing time than the frozen AMT group while frozen AMT group had lower original disease recurrence rates than LKP group.

Competing Interests: The authors report no conflicts of interest.

Titel:	Comparative Study on the Efficacy of Frozen Amniotic Membrane Transplantation and Lamellar Keratoplasty in the Treatment of Mooren Ulcer.
Autor/in / Beteiligte Person:	Chen, Y ; Gao, R ; Gao, M ; Liu, Q ; Song, L
Link:	Full Text Finder (Volltext)
Zeitschrift:	The Journal of craniofacial surgery, Jg. 32 (2021-03-01), Heft 2, S. 637-641
Veröffentlichung:	<2014-> : Hagerstown, MD : Lippincott Williams & Wilkins ; <i>Original Publication</i>: Burlington, Ont. : B.C. Decker, c1990-, 2021
Medientyp:	academicJournal
ISSN:	1536-3732 (electronic)
DOI:	10.1097/SCS.0000000000007063
Schlagwort:	Amnion transplantation Humans Treatment Outcome Ulcer Corneal Diseases surgery Corneal Transplantation Corneal Ulcer surgery
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Craniofac Surg] 2021 Mar-Apr 01; Vol. 32 (2), pp. 637-641. MeSH Terms: Corneal Diseases* / surgery ; Corneal Transplantation* ; Corneal Ulcer* / surgery ; Amnion / transplantation ; Humans ; Treatment Outcome ; Ulcer References: Jerez-Peña M, Salvador-Culla B, de la Paz MF, et al. Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer. Eur J Ophthalmol 2020; 1–6. ; Liu J, Shi W, Li S, et al. Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer. Br J Ophthalmol 2015; 99:778–783. ; Li S, Deng Y, Du C, et al. Rapid deterioration of Mooren's ulcers after conjunctival flap: a review of 2 cases. BMC Ophthalmol 2017; 17:93. ; Lal I, Shivanagari SB, Ali MH, et al. Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer. Br J Ophthalmol 2016; 100:971–975. ; Chen G, Tzekov R, Li W, et al. Deep anterior lamellar keratoplasty versus penetrating keratoplasty: a meta-analysis of randomized controlled trials. Cornea 2016; 35:169–174. ; Buzzonetti L, Ardia R, Petroni S, et al. Four years of corneal keratoplasty in Italian paediatric patients: indications and clinical outcomes. Graefes Arch Clin Exp Ophthalmol 2016; 254:2239–2245. ; Coster DJ, Lowe MT, Keane MC, et al. A comparison of lamellar and penetrating keratoplasty outcomes: a registry study. Ophthalmology 2014; 121:979–987. ; Tan DT, Por YM. Current treatment options for corneal ectasia. Curr Opin Ophthalmol 2007; 18:284–289. ; Mamede AC, Carvalho MJ, Abrantes AM, et al. Amniotic membrane: from structure and functions to clinical applications. Cell Tissue Res 2012; 349:447–458. ; Ashraf NN, Adhi MI. Outcome of application of amniotic membrane graft in ocular surface disorders. JPMA 2017; 67:1045–1049. ; Alhassan MB, Rabiu M, Agbabiaka IO. Interventions for Mooren's ulcer. Cochrane Database Syst Rev 2014; Art. No.: CD006131. ; Daya SM. Conjunctival-limbal autograft. Curr Opin Ophthalmol 2017; 28:370–376. ; Shinton AJ, Tsatsos M, Konstantopoulos A, et al. Impact of graft thickness on visual acuity after Descemet's stripping endothelial keratoplasty. Br J Ophthalmol 2012; 96:246–249. ; Hou G, Xu J, Sun B, et al. Amniotic membrane transplantation with autograft for ocular surface reconstruction in chemical and thermal burns. Chin J Pract Ophthalmol 2003; 021:652–654. ; Wang X, Wang W, Xu J, et al. Pretreatment of rapamycin before allogenic corneal transplant promotes graft survival through increasing CD4(+)CD25(+)Foxp3(+) regulatory T cells. Exp Clin Transplant 2013; 11:56–62. ; Kosker M, Suri K, Duman F, et al. Long-term outcomes of penetrating keratoplasty and Descemet stripping endothelial keratoplasty for Fuchs endothelial dystrophy: fellow eye comparison. Cornea 2013; 32:1083–1088. ; Shi W. Consensus among Chinese experts on drugs for corneal transplantation (2016). Chin J Ophthalmol 2016; 732–737. ; Ngan ND, Chau HT. Amniotic membrane transplantation for Mooren's ulcer. Clin Exp Ophthalmol 2011; 39:386–392. ; Ke L, Shen D, Wang H, et al. Lamellar keratoplasty combined with amniotic membrane transplantation for the treatment of corneal perforations: a clinical and in vivo confocal microscopy study. Biomed Res Int 2020; 2020:8. ; Toda A, Okabe M, Yoshida T, et al. The potential of amniotic membrane/amnion-derived cells for regeneration of various tissues. J Pharmacol Sci 2007; 105:215–228. ; Letko E, Stechschulte SU, Kenyon KR, et al. Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers. Arch Ophthalmol (Chicago, Ill: 1960) 2001; 119:659–663. ; Gabrić N, Mravicić I, Dekaris I, et al. Human amniotic membrane in the reconstruction of the ocular surface. Doc Ophthalmol 1999; 98:273–283. ; Shi Y, Cui H. Advances in clinical treatment of corneal neovascularization. Recent Adv Ophthalmol 2016; 36:1097–1100. ; Bachmann B, Taylor RS, Cursiefen C. Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis. Ophthalmology 2010; 117: 1300-1305.e1307. ; Perera C, Jhanji V, Vajpayee RB. Factors influencing outcomes of the treatment of allograft corneal rejection. Am J Ophthalmol 2011; 152: 358-363.e352. ; Yang L, Xiao J, Wang J, et al. Clinical characteristics and risk factors of recurrent Mooren's ulcer. J Ophthalmol 2017; 2017:7. ; Gottsch JD, Li Q, Ashraf MF, et al. Defensin gene expression in the cornea. Curr Eye Res 1998; 17:1082–1086. ; Li L, Li Y, Cao Q. Prevention and treatment of corneal rejection after corneal transplantation. Int Eye Sci 2011; 152–153. ; Ang M, Soh Y, Htoon HM, et al. Five-year graft survival comparing descemet stripping automated endothelial keratoplasty and penetrating keratoplasty. Ophthalmology 2016; 123:1646–1652. ; Cheng S, Wang G, Li X, et al. Clinical observation of improved amniotic membrane transplantation in the treatment of corneal ulcer. J Clin Ophthalmol 2019; 027:37–39. ; Zhou S, Chen J, Liu Z, et al. Clinical study on reconstruction of severely burned ocular surface in acute stage by amniotic membrane transplantation. Chin J Ophthalmol 2004; 040:97–100. Entry Date(s): Date Created: 20210311 Date Completed: 20210623 Latest Revision: 20230712 Update Code: 20240513

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Comparative Study on the Efficacy of Frozen Amniotic Membrane Transplantation and Lamellar Keratoplasty in the Treatment of Mooren Ulcer.