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Objective: Bone responsiveness to parathyroid hormone (PTH) in different subtypes of pseudohypoparathyroidism type 1 (PHP1) remains controversial. We aimed to investigate this phenomenon using bone turnover markers (BTMs) in a large cohort of PHP1 patients.

Design: Retrospective study.

Patients: Sixty-three PHP1 patients diagnosed by molecular analysis were used as subjects, and 48 sex- and age-matched patients with nonsurgical hypoparathyroidism (NS-HP) were used for comparison.

Measurements: Bone turnover markers, alkaline phosphatase (ALP), C-terminal telopeptide of type I collagen (β-CTX) and related parameters in PHP1 were compared among different subtypes and with NS-HP.

Results: Among all the PHP1 patients (15 PHP1A, 14 familial 1B and 34 sporadic 1B), 23.8% had elevated baseline BTM levels. No significant difference was found in the β-CTX levels among different subtypes. The β-CTX level was positively correlated with the PTH level for all PHP1, PHP1B and PHP1A patients (B = 0.001, 0.001 and 0.004, respectively; all p < .05). The BTM levels of PHP1 patients were significantly higher than those of NS-HP patients (β-CTX: 0.56 ng/ml vs. 0.20 ng/ml, p = .001; ALP: 105 U/L vs. 72 U/L, p = .001). The serum β-CTX levels in different PHP1 subtypes were all significantly higher than those in NS-HP patients in adults. Among the 22 followed up patients, changes in BTMs were associated with changes in PTH (β-CTX: r = .507, p = .023; ALP: r = .475, p = .034).

Conclusions: Bone tissues respond to PTH in different PHP1 subtypes, and it is reasonable to monitor and normalize PTH and BTMs in addition to the serum and urinary calcium levels in the follow-up of PHP1 patients.

Titel:	Bone turnover markers are associated with the PTH levels in different subtypes of pseudohypoparathyroidism type 1 patients.
Autor/in / Beteiligte Person:	Duan, X ; Yang, Y ; Wang, O ; Nie, M ; Chu, X ; Quan, T ; Guan, W ; Jiang, Y ; Li, M ; Xia, W ; Xing, X
Link:	Full Text Finder (Volltext)
Zeitschrift:	Clinical endocrinology, Jg. 95 (2021-08-01), Heft 2, S. 277-285
Veröffentlichung:	<2003->: Oxford : Blackwell Publishing ; <i>Original Publication</i>: Oxford, Blackwell Scientific Publications., 2021
Medientyp:	academicJournal
ISSN:	1365-2265 (electronic)
DOI:	10.1111/cen.14496
Schlagwort:	Adult Biomarkers Bone Remodeling Collagen Type I Humans Retrospective Studies Parathyroid Hormone Pseudohypoparathyroidism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Clin Endocrinol (Oxf)] 2021 Aug; Vol. 95 (2), pp. 277-285. <i>Date of Electronic Publication: </i>2021 May 19. MeSH Terms: Parathyroid Hormone* ; Pseudohypoparathyroidism* ; Adult ; Biomarkers ; Bone Remodeling ; Collagen Type I ; Humans ; Retrospective Studies References: Albright FBCH. Pseudohypoparathyroidism - an example of ‘Seabright-Bantam syndrome’. Endocrinology. 1942;30:922-932. ; Mantovani G, Bastepe M, Monk D, et al. Diagnosis and management of pseudohypoparathyroidism and related disorders: first international consensus statement. Nat Rev Endocrinol. 2018;14:476-500. ; Mantovani G, Spada A. Mutations in the Gs alpha gene causing hormone resistance. Best Pract Res Clin Endocrinol Metab. 2006;20:501-513. ; Mantovani G, Ballare E, Giammona E, Beck-Peccoz P, Spada A. 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Grant Information: 2017-I2M-1-001 Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine (CAMS-I2M); 81873641 National Natural Science Foundation of China; 82070817 National Natural Science Foundation of China Contributed Indexing: Keywords: bone responsiveness; bone turnover markers; molecular subtype; parathyroid hormone; pseudohypoparathyroidism Substance Nomenclature: 0 (Biomarkers) ; 0 (Collagen Type I) ; 0 (PTH protein, human) ; 0 (Parathyroid Hormone) Entry Date(s): Date Created: 20210507 Date Completed: 20211027 Latest Revision: 20220531 Update Code: 20240513

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Bone turnover markers are associated with the PTH levels in different subtypes of pseudohypoparathyroidism type 1 patients.