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Objectives: The main cardiac features of primary aldosteronism (PA) are impaired left ventricular (LV) diastolic function, and some articles also reported more cardiac fibrosis in PA patients. However, the correlation between LV dysfunction and diffuse myocardial fibrosis in PA remains unknown.

Methods: We enrolled 84 PA patients and 28 essential hypertension (EH) patients in West China Hospital. Cardiac magnetic resonance imaging (CMR) contrast enhancement was arranged for all subjects. Postcontrast T1 time and left ventricular myocardial strains and strain rates were measured.

Results: 76 PA patients and 27 essential hypertension (EH) patients were included in the final analysis. Blood pressure, LV mass indexes, and LV ejection fractions were comparable in both groups, while the global circumferential peak diastolic strain rate (PDSR) was lower (0.9 ± 0.3 vs. 1.1 ± 0.4, p <0.01) and the postcontrast T1 time was shorter (520 ± 38 vs. 538 ± 27, p = 0.01) in PA patients than those in EH patients. Postcontrast T1 time (p = 0.01) was independently related to global circumferential PDSR after adjusting for age and duration of hypertension in PA patients. Furthermore, plasma aldosterone concentration was negatively associated with postcontrast T1 time (R = -0.253, p = 0.028) in PA patients.

Conclusions: The global circumferential PDSR derived by CMR is decreased, and the diffuse myocardial fibrosis is increased in PA patients compared to those in blood pressure matched EH patients. The severity of cardiac diastolic dysfunction independently relates to the degree of diffuse myocardial fibrosis in PA patients, and the diffuse myocardial fibrosis may be caused by high PAC level.

Clinical Trial Registration: http://www.chictr.org.cn/listbycreater.asp, identifier ChiCTR2000031792.

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Titel:	CMR-Verified Myocardial Fibrosis Is Associated With Subclinical Diastolic Dysfunction in Primary Aldosteronism Patients.
Autor/in / Beteiligte Person:	Zhou, F ; Wu, T ; Wang, W ; Cheng, W ; Wan, S ; Tian, H ; Chen, T ; Sun, J ; Ren, Y
Link:	Full Text Finder (Volltext)
Zeitschrift:	Frontiers in endocrinology, Jg. 12 (2021-05-14), S. 672557
Veröffentlichung:	[Lausanne : Frontiers Research Foundation], 2021
Medientyp:	academicJournal
ISSN:	1664-2392 (print)
DOI:	10.3389/fendo.2021.672557
Schlagwort:	Adult Aged Female Fibrosis diagnostic imaging Heart diagnostic imaging Humans Hyperaldosteronism diagnostic imaging Magnetic Resonance Imaging, Cine Male Middle Aged Ventricular Dysfunction, Left diagnostic imaging Ventricular Dysfunction, Left physiopathology Young Adult Diastole physiology Fibrosis physiopathology Heart physiopathology Hyperaldosteronism physiopathology Myocardium
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Front Endocrinol (Lausanne)] 2021 May 14; Vol. 12, pp. 672557. <i>Date of Electronic Publication: </i>2021 May 14 (<i>Print Publication: </i>2021). MeSH Terms: Myocardium* ; Diastole / physiology ; Fibrosis / physiopathology ; Heart / physiopathology ; Hyperaldosteronism / physiopathology ; Adult ; Aged ; Female ; Fibrosis / diagnostic imaging ; Heart / diagnostic imaging ; Humans ; Hyperaldosteronism / diagnostic imaging ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Ventricular Dysfunction, Left / diagnostic imaging ; Ventricular Dysfunction, Left / physiopathology ; Young Adult References: Radiology. 2012 Dec;265(3):724-32. (PMID: 23091172) ; J Magn Reson Imaging. 2020 Dec;52(6):1714-1721. (PMID: 32525266) ; J Magn Reson Imaging. 2012 Jun;35(6):1349-55. (PMID: 22282406) ; Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H176-84. (PMID: 12388314) ; J Biol Chem. 2009 Jun 12;284(24):16633-16647. (PMID: 19372600) ; JACC Cardiovasc Imaging. 2014 Oct;7(10):991-7. (PMID: 25240451) ; J Nutr. 2014 Oct;144(10):1571-8. (PMID: 25122644) ; JACC Cardiovasc Imaging. 2020 Oct;13(10):2149-2159. (PMID: 32950448) ; J Mol Cell Cardiol. 2000 Jun;32(6):865-79. (PMID: 10888242) ; J Am Coll Cardiol. 2005 Apr 19;45(8):1243-8. (PMID: 15837256) ; J Cardiovasc Magn Reson. 2017 Oct 9;19(1):75. (PMID: 28992817) ; Hypertension. 2013 Aug;62(2):331-6. (PMID: 23753408) ; Endocrinology. 2010 Sep;151(9):4467-76. (PMID: 20591974) ; JACC Cardiovasc Imaging. 2020 Jan;13(1 Pt 2):245-257. (PMID: 31202759) ; Endocr Connect. 2018 Mar;7(3):413-424. (PMID: 29440130) ; Cardiovasc Res. 1992 Jul;26(7):671-7. (PMID: 1423431) ; Ann Cardiol Angeiol (Paris). 2018 Nov;67(5):315-320. (PMID: 30327134) ; Curr Hypertens Rep. 2013 Aug;15(4):395-400. (PMID: 23686824) ; Circ Cardiovasc Imaging. 2013 Nov;6(6):1056-65. (PMID: 24036385) ; J Am Coll Cardiol. 2008 Nov 4;52(19):1574-80. (PMID: 19007595) ; Int J Cardiol. 2019 Oct 1;292:141-147. (PMID: 31256994) ; J Hypertens. 2018 Feb;36(2):353-360. (PMID: 28902663) ; J Hypertens. 2020 Feb;38(2):332-339. (PMID: 31834121) ; J Clin Endocrinol Metab. 2016 May;101(5):1889-916. (PMID: 26934393) ; Int J Cardiol Hypertens. 2020 Apr 15;5:100029. (PMID: 33447758) ; J Cardiovasc Magn Reson. 2012 Oct 29;14:76. (PMID: 23107451) ; Hypertension. 2008 Sep;52(3):529-34. (PMID: 18645048) ; Circ Cardiovasc Imaging. 2016 Jun;9(6):. (PMID: 27307552) ; Amyloid. 2019 Mar;26(1):45-51. (PMID: 30931628) ; Circ Cardiovasc Imaging. 2012 Jan;5(1):51-9. (PMID: 22135399) ; J Mol Cell Cardiol. 2018 Feb;115:32-38. (PMID: 29289651) ; Circ Cardiovasc Imaging. 2012 Nov;5(6):740-7. (PMID: 23019275) ; J Hypertens. 2012 Aug;30(8):1606-13. (PMID: 22688266) ; J Hypertens. 2020 Sep;38(9):1841-1848. (PMID: 32384388) ; J Hum Hypertens. 2021 Feb;35(2):131-147. (PMID: 33067554) ; J Card Fail. 2004 Dec;10(6):511-8. (PMID: 15599842) ; J Magn Reson Imaging. 2018 Aug;48(2):415-422. (PMID: 29328539) ; Hypertension. 2007 Nov;50(5):911-8. (PMID: 17893375) ; Hypertension. 2012 Sep;60(3):618-24. (PMID: 22824982) ; N Engl J Med. 2006 Jul 20;355(3):251-9. (PMID: 16855265) Contributed Indexing: Keywords: CMR; essential hypertension; left ventricular function; myocardial fibrosis; primary aldosteronism; the global circumferential PDSR Molecular Sequence: ChiCTR ChiCTR2000031792 Entry Date(s): Date Created: 20210531 Date Completed: 20211220 Latest Revision: 20211220 Update Code: 20231215 PubMed Central ID: PMC8160454

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CMR-Verified Myocardial Fibrosis Is Associated With Subclinical Diastolic Dysfunction in Primary Aldosteronism Patients.