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Objective: To evaluate the effectiveness of Chinese Herbal Medicine (CHM) on leukopenia/neutropenia induced by chemotherapy in adults with colorectal cancer (CRC).

Methods: Eight electronic databases were searched from their inception to June 2020. Randomized controlled trials with clarified sequence generation were qualified. Two reviewers independently conducted the screening and data extraction. Methodological quality was assessed using the Risk of Bias tool. RevMan 5.4 was applied to the meta-analysis.

Results: Twenty-seven studies involving 1867 participants were qualified, of which 26 were included in the quantitative synthesis. Meta-analysis showed that CHM significantly reduced the incidence of leukopenia induced by chemotherapy (RR = 0.69; 95% CI 0.59-0.82), as well as the grade 3/4 leukopenia (RR = 0.71; 95% CI 0.55-0.90). Meanwhile,CHM decreased the occurrence of neutropenia (RR = 0.52, 95% CI 0.35-0.77), especially for the grades 3/4 neutropenia (RR = 0.42, 95% CI 0.27-0.64). Twenty-six of the included studies focused on the adverse events related to CHM.

Conclusion: CHM may relieve neutropenia/leukopenia induced by chemotherapy in adults with colorectal cancer.

Titel:	Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis.
Autor/in / Beteiligte Person:	Yan, SH ; Feng, S ; Xu, Y ; Yan, YZ ; He, B ; Sun, LY ; Pang, B ; Liu, WJ ; Xu, YY ; Zhao, N ; Tang, M ; Chen, Y ; Yu, MK ; Yang, YF
Link:	Full Text Finder (Volltext)
Zeitschrift:	Integrative cancer therapies, Jg. 20 (2021), S. 15347354211021654
Veröffentlichung:	Thousand Oaks, CA : Sage Publications, c2002-, 2021
Medientyp:	academicJournal
ISSN:	1552-695X (electronic)
DOI:	10.1177/15347354211021654
Schlagwort:	Adult Herbal Medicine Humans Phytotherapy Colorectal Neoplasms drug therapy Drugs, Chinese Herbal therapeutic use Neutropenia chemically induced Neutropenia drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review Language: English [Integr Cancer Ther] 2021 Jan-Dec; Vol. 20, pp. 15347354211021654. MeSH Terms: Colorectal Neoplasms* / drug therapy ; Drugs, Chinese Herbal* / therapeutic use ; Neutropenia* / chemically induced ; Neutropenia* / drug therapy ; Adult ; Herbal Medicine ; Humans ; Phytotherapy References: Lancet. 2018 Nov 10;392(10159):1736-1788. (PMID: 30496103) ; J Clin Oncol. 2015 Nov 10;33(32):3733-40. (PMID: 26324362) ; N Engl J Med. 1991 Jul 18;325(3):164-70. (PMID: 1711156) ; Front Oncol. 2019 Aug 13;9:749. (PMID: 31456940) ; Toxicol Appl Pharmacol. 2020 May 15;395:114976. (PMID: 32222375) ; Ann Intern Med. 2006 Mar 7;144(5):364-7. (PMID: 16520478) ; Lancet. 1995 Apr 15;345(8955):939-44. (PMID: 7715291) ; Farm Hosp. 2019 Sep 01;43(5):158-162. (PMID: 31469628) ; Crit Rev Oncol Hematol. 2016 Sep;105:18-34. (PMID: 27497028) ; Support Care Cancer. 2019 Jul;27(7):2569-2577. (PMID: 30443809) ; Front Pharmacol. 2020 Feb 27;11:132. (PMID: 32174834) ; Medicine (Baltimore). 2021 Jan 29;100(4):e24307. (PMID: 33530221) ; BMC Complement Altern Med. 2019 Dec 9;19(1):356. (PMID: 31818289) ; J Clin Oncol. 2008 Apr 20;26(12):2006-12. (PMID: 18421053) ; Phytother Res. 2014 Jul;28(7):976-91. (PMID: 24343974) ; J Clin Oncol. 2005 Feb 20;23(6):1178-84. (PMID: 15718314) ; N Engl J Med. 2018 Mar 29;378(13):1177-1188. (PMID: 29590544) ; Invest New Drugs. 1989 Apr;7(1):13-25. (PMID: 2661480) ; Lancet Oncol. 2018 Apr;19(4):562-578. (PMID: 29611518) ; Cochrane Database Syst Rev. 2009 Apr 15;(2):CD006875. (PMID: 19370656) ; J Clin Oncol. 2005 Dec 1;23(34):8671-8. (PMID: 16314627) ; J Clin Oncol. 2007 Jun 1;25(16):2198-204. (PMID: 17470851) ; J Cancer Res Clin Oncol. 2011 Jun;137(6):927-38. (PMID: 20936301) ; Transfus Med Hemother. 2013 Aug;40(4):258-64. (PMID: 24179474) ; Ann Oncol. 1999 Nov;10(11):1317-20. (PMID: 10631459) ; Br J Cancer. 2009 Jun 2;100(11):1720-4. (PMID: 19436300) ; J Clin Oncol. 2007 Jan 1;25(1):102-9. (PMID: 17194911) ; Cochrane Database Syst Rev. 2008 Oct 08;(4):CD003189. (PMID: 18843642) ; Cochrane Database Syst Rev. 2014 Oct 30;(10):CD003039. (PMID: 25356786) ; Surg Oncol. 2010 Mar;19(1):38-45. (PMID: 19345093) ; J Clin Oncol. 2009 Jul 1;27(19):3109-16. (PMID: 19451431) ; Oncologist. 2018 Dec;23(12):1436-1445. (PMID: 29802221) ; J Clin Oncol. 1996 Oct;14(10):2682-7. (PMID: 8874327) ; J Clin Oncol. 2011 Jul 10;29(20):2781-6. (PMID: 21646604) ; Biomed Pharmacother. 2019 Jul;115:108927. (PMID: 31071509) ; J Clin Oncol. 1994 Jan;12(1):14-20. (PMID: 7677801) ; J Clin Oncol. 1998 Jan;16(1):295-300. (PMID: 9440756) ; CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593) ; Ann Intern Med. 2010 Jun 1;152(11):726-32. (PMID: 20335313) ; Am J Hematol. 2003 Aug;73(4):294-5. (PMID: 12879437) Contributed Indexing: Keywords: Chinese herbal medicine; chemotherapy; colorectal cancer; leukopenia; neutropenia Substance Nomenclature: 0 (Drugs, Chinese Herbal) Entry Date(s): Date Created: 20210612 Date Completed: 20211011 Latest Revision: 20211011 Update Code: 20231215 PubMed Central ID: PMC8202260

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Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis.