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Duchenne muscular dystrophy (DMD) is a genetic disease associated with progressive skeletal muscle degeneration. In humans, DMD has an early onset, causes developmental delays, and is a devastating disease that drastically diminishes the quality of life of young individuals affected. The objective of this study was to evaluate the effects of a swimming protocol on memory and oxidative stress in an animal model of DMD. Male mdx and wild-type mice aged ≥ 28 days were used in this study. The animals were trained for a stepped swimming protocol for four consecutive weeks. The swimming protocol significantly reduced the levels of lipid peroxidation and protein carbonylation in the gastrocnemius, hippocampus, and striatum in the exercised animals. It also prevented lipid peroxidation in the diaphragm. Moreover, it increased the free thiol levels in the gastrocnemius, the diaphragm, and all central nervous system structures. The results showed that the protocol that applied swimming as a low-intensity aerobic exercise for 4 weeks prevented aversive memory and habituation in mdx mice.

Titel:	Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy.
Autor/in / Beteiligte Person:	Nocetti, PM ; Alberti, A ; Freiberger, V ; Ventura, L ; Grigollo, LR ; Andreau, CS ; Júnior, RJN ; Martins, DF ; Comim, CM
Link:	View record at Springer (Volltext)
Zeitschrift:	Molecular neurobiology, Jg. 58 (2021-10-01), Heft 10, S. 5067-5077
Veröffentlichung:	Clifton, NJ : Humana Press, c1987-, 2021
Medientyp:	academicJournal
ISSN:	1559-1182 (electronic)
DOI:	10.1007/s12035-021-02482-y
Schlagwort:	Animals Brain metabolism Male Memory Disorders genetics Memory Disorders metabolism Memory Disorders therapy Mice Mice, Inbred C57BL Mice, Inbred mdx Muscular Dystrophy, Duchenne psychology Oxidative Stress physiology Physical Conditioning, Animal methods Physical Conditioning, Animal psychology Swimming psychology Antioxidants metabolism Memory physiology Muscular Dystrophy, Duchenne metabolism Muscular Dystrophy, Duchenne therapy Physical Conditioning, Animal physiology Swimming physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Mol Neurobiol] 2021 Oct; Vol. 58 (10), pp. 5067-5077. <i>Date of Electronic Publication: </i>2021 Jul 10. MeSH Terms: Antioxidants / metabolism ; Memory / physiology ; Muscular Dystrophy, Duchenne / metabolism ; Muscular Dystrophy, Duchenne / therapy ; Physical Conditioning, Animal / physiology ; Swimming / physiology ; Animals ; Brain / metabolism ; Male ; Memory Disorders / genetics ; Memory Disorders / metabolism ; Memory Disorders / therapy ; Mice ; Mice, Inbred C57BL ; Mice, Inbred mdx ; Muscular Dystrophy, Duchenne / psychology ; Oxidative Stress / physiology ; Physical Conditioning, Animal / methods ; Physical Conditioning, Animal / psychology ; Swimming / psychology References: Sinha R, Sarkar S, Khaitan T, Dutta S (2017) Duchenne muscular dystrophy: case report and review. J Fam Med Prim Care 6(3):654. 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(PMID: 10.1111/j.1471-4159.1992.tb10990.x) Contributed Indexing: Keywords: Animal; Duchenne muscular dystrophy; Mice; Oxidative stress; Swimming Substance Nomenclature: 0 (Antioxidants) Entry Date(s): Date Created: 20210710 Date Completed: 20220203 Latest Revision: 20220203 Update Code: 20240513

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Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy.