Einzeltreffer — DigiBib

The purpose of this study is to investigate the effect of varying coronary flow reserve (CFR) values on the calculation of computationally-derived fractional flow reserve (FFR). CFR reflects both vessel resistance due to an epicardial stenosis, and resistance in the distal microvascular tissue. Patients may have a wide range of CFR related to the tissue substrate that is independent of epicardial stenosis levels. Most computationally based virtual FFR values such as FFR CT do not measure patient specific CFR values but use a population-average value to create hyperemic flow conditions. In this study, a coronary arterial computational geometry was constructed using magnetic resonance angiography (MRA) data acquired in a patient with moderate CAD. Coronary flow waveforms under rest and stress conditions were acquired in 13 patients with phase-contrast magnetic resonance (PCMR) to calculate CFR, and these flow waveforms and CFR values were applied as inlet flow boundary conditions to determine FFR based on computational fluid dynamics (CFD) simulations. The stress flow waveform gave a measure of the functional significance of the vessel when evaluated with the physiologically-accurate behavior with the patient-specific CFR. The resting flow waveform was then scaled by a series of CFR values determined in the 13 patients to simulate how hyperemic flow and CFR affects FFR values. We found that FFR values calculated using non-patient-specific CFR values did not accurately predict those calculated with the true hyperemic flow waveform. This indicates that both patient-specific anatomic and flow information are required to accurately non-invasively assess the functional significance of coronary lesions.

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Titel:	Effect of Patient-Specific Coronary Flow Reserve Values on the Accuracy of MRI-Based Virtual Fractional Flow Reserve.
Autor/in / Beteiligte Person:	Hair, J ; Timmins, L ; El Sayed, R ; Samady, H ; Oshinski, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Frontiers in cardiovascular medicine, Jg. 8 (2021-07-02), S. 663767
Veröffentlichung:	Lausanne : Frontiers Media S.A., [2014]-, 2021
Medientyp:	academicJournal
ISSN:	2297-055X (print)
DOI:	10.3389/fcvm.2021.663767
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Front Cardiovasc Med] 2021 Jul 02; Vol. 8, pp. 663767. <i>Date of Electronic Publication: </i>2021 Jul 02 (<i>Print Publication: </i>2021). References: Lancet. 1986 Feb 8;1(8476):307-10. (PMID: 2868172) ; J Magn Reson Imaging. 1999 Nov;10(5):728-33. (PMID: 10548782) ; Am J Cardiol. 1974 Jan;33(1):87-94. (PMID: 4808557) ; JACC Cardiovasc Imaging. 2012 Feb;5(2):193-202. (PMID: 22340827) ; BMC Med Imaging. 2010 Jan 11;10:1. (PMID: 20064248) ; Circulation. 1990 Nov;82(5):1595-606. (PMID: 2225364) ; JAMA Cardiol. 2017 Jul 1;2(7):803-810. (PMID: 28538960) ; J Am Coll Cardiol. 2013 Oct 29;62(18):1639-1653. (PMID: 23954338) ; J Comput Assist Tomogr. 1999 Jul-Aug;23(4):567-76. (PMID: 10433289) ; N Engl J Med. 2014 Sep 25;371(13):1208-17. (PMID: 25176289) ; J Cardiovasc Magn Reson. 2018 Apr 30;20(1):29. (PMID: 29706134) ; Circulation. 2008 Mar 11;117(10):1283-91. (PMID: 18268144) ; J Am Coll Cardiol. 2012 Dec 4;60(22):2337-9. (PMID: 23194945) ; Radiology. 1999 Apr;211(1):129-35. (PMID: 10189462) ; J Am Coll Cardiol. 2007 May 29;49(21):2105-11. (PMID: 17531660) ; N Engl J Med. 2012 Sep 13;367(11):991-1001. (PMID: 22924638) ; J Biomech. 2008;41(3):595-602. (PMID: 18036532) ; J Am Coll Cardiol. 2013 Jul 23;62(4):357-96. (PMID: 23665367) ; Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H878-85. (PMID: 16126811) ; J Appl Physiol (1985). 2008 May;104(5):1281-6. (PMID: 18323461) ; Circulation. 1995 Dec 1;92(11):3183-93. (PMID: 7586302) ; Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1591-5. (PMID: 11607632) ; AJNR Am J Neuroradiol. 2018 Mar;39(3):485-487. (PMID: 29269408) ; Eur Radiol. 2006 May;16(5):1124-30. (PMID: 16411084) ; Ann Biomed Eng. 2015 Jan;43(1):94-106. (PMID: 25316593) ; J Am Coll Cardiol. 2013 Jun 4;61(22):2233-41. (PMID: 23562923) ; Curr Cardiol Rep. 2014 May;16(5):484. (PMID: 24652346) ; Circulation. 2015 Jan 27;131(4):e29-322. (PMID: 25520374) ; JACC Cardiovasc Interv. 2017 May 22;10(10):999-1007. (PMID: 28521932) ; Circulation. 2000 May 23;101(20):2375-81. (PMID: 10821813) ; J Am Coll Cardiol. 2009 Jun 30;54(1):69-76. (PMID: 19555843) ; IEEE Trans Med Imaging. 2003 May;22(5):674-84. (PMID: 12846436) ; J Cardiovasc Magn Reson. 2015 Jul 14;17:57. (PMID: 26170046) ; Magn Reson Med. 2017 Feb;77(2):529-537. (PMID: 28019028) ; Proc Natl Acad Sci U S A. 1926 Mar;12(3):207-14. (PMID: 16576980) ; Biometrics. 1989 Mar;45(1):255-68. (PMID: 2720055) Grant Information: R01 EB027774 United States EB NIBIB NIH HHS; R01 HL150608 United States HL NHLBI NIH HHS; UL1 TR002378 United States TR NCATS NIH HHS Contributed Indexing: Keywords: CFD; CFR; FFR; MRI; vFFR Entry Date(s): Date Created: 20210719 Latest Revision: 20211117 Update Code: 20240513 PubMed Central ID: PMC8282891

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Effect of Patient-Specific Coronary Flow Reserve Values on the Accuracy of MRI-Based Virtual Fractional Flow Reserve.