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Neuropeptides are small proteinaceous molecules (3-100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n = 24) and depressed suicide (DS) (n = 24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression.

Titel:	Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study.
Autor/in / Beteiligte Person:	Sharma, A ; Ren, X ; Zhang, H ; Pandey, GN
Zeitschrift:	Progress in neuro-psychopharmacology & biological psychiatry, Jg. 112 (2022-01-10), S. 110428
Veröffentlichung:	Oxford ; New York : Pergamon Press, c1982-, 2022
Medientyp:	academicJournal
ISSN:	1878-4216 (electronic)
DOI:	10.1016/j.pnpbp.2021.110428
Schlagwort:	Adult Female Hippocampus Humans Male Prefrontal Cortex Autopsy Depression physiopathology Neuropeptide Y physiology RNA, Messenger metabolism Receptors, Neuropeptide Y physiology Stress, Psychological physiopathology Suicide
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural Language: English [Prog Neuropsychopharmacol Biol Psychiatry] 2022 Jan 10; Vol. 112, pp. 110428. <i>Date of Electronic Publication: </i>2021 Aug 17. MeSH Terms: Autopsy* ; Suicide* ; Depression / physiopathology ; Neuropeptide Y / physiology ; RNA, Messenger / metabolism ; Receptors, Neuropeptide Y / physiology ; Stress, Psychological / *physiopathology ; Adult ; Female ; Hippocampus ; Humans ; Male ; Prefrontal Cortex References: Brain Res. 2006 Jun 20;1095(1):154-8. (PMID: 16713589) ; Behav Brain Res. 2003 May 15;141(2):251-5. (PMID: 12742262) ; Neuropeptides. 2016 Feb;55:99-109. (PMID: 26441327) ; Eur J Pharmacol. 1988 Mar 15;147(3):465-7. (PMID: 2967771) ; Trends Neurosci. 1994 Feb;17(2):80-5. (PMID: 7512773) ; Neuropsychopharmacology. 2002 Nov;27(5):756-64. (PMID: 12431850) ; Int J Neuropsychopharmacol. 2012 Sep;15(8):1051-61. (PMID: 22008251) ; J Consult Clin Psychol. 2020 Jan;88(1):25-38. (PMID: 31841022) ; Brain Behav Immun. 2019 Jan;75:101-111. (PMID: 30266463) ; Neurosci Lett. 1996 Sep 20;216(1):57-60. (PMID: 8892391) ; J Neurosci Res. 2004 Sep 1;77(5):723-9. (PMID: 15352219) ; Front Behav Neurosci. 2018 Aug 07;12:159. (PMID: 30131681) ; Cell Tissue Res. 2006 Nov;326(2):583-98. (PMID: 16847638) ; Psychopharmacology (Berl). 1989;98(4):524-9. (PMID: 2570434) ; Neuropharmacology. 2002 Dec;43(7):1165-72. (PMID: 12504923) ; Biomed Res Int. 2013;2013:687575. (PMID: 23986909) ; Expert Opin Ther Targets. 2011 Nov;15(11):1317-31. (PMID: 21995655) ; Brain Res Dev Brain Res. 2001 Nov 26;131(1-2):149-52. (PMID: 11718845) ; Neuropsychopharmacology. 2001 Jul;25(1):91-7. (PMID: 11377922) ; Eur Neuropsychopharmacol. 2014 Dec;24(12):1907-15. (PMID: 25453484) ; Neurosci Biobehav Rev. 2002 May;26(3):259-83. (PMID: 12034130) ; Neuropeptides. 2020 Apr;80:102001. (PMID: 31916978) ; Front Endocrinol (Lausanne). 2013 Feb 04;4:5. (PMID: 23382728) ; J Psychiatr Res. 2004 Mar-Apr;38(2):113-21. (PMID: 14757324) ; J Endocrinol. 2008 May;197(2):421-7. (PMID: 18434372) ; Mol Psychiatry. 2013 Jun;18(6):646-55. (PMID: 22801411) ; Neuropsychopharmacology. 2000 Nov;23(5):477-501. (PMID: 11027914) ; Br J Pharmacol. 2012 Jun;166(4):1461-73. (PMID: 22289084) ; Neuroscience. 2009 Feb 18;158(4):1717-30. (PMID: 19121371) ; Eur Neuropsychopharmacol. 2004 Dec;14(6):479-85. (PMID: 15589387) ; J Psychopharmacol. 2010 Oct;24(10):1541-9. (PMID: 19351805) ; Pharmacol Biochem Behav. 2002 Mar;71(3):419-23. (PMID: 11830176) ; Int J Neuropsychopharmacol. 2014 Oct 31;18(1):. (PMID: 25539507) ; Int J Neuropsychopharmacol. 2018 Jan 1;21(1):3-11. (PMID: 29186416) ; Biochem Biophys Res Commun. 2000 Oct 14;277(1):264-9. (PMID: 11027673) ; Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12852-7. (PMID: 11058155) ; Psychoneuroendocrinology. 2013 Nov;38(11):2628-39. (PMID: 23845513) ; Peptides. 1996;17(3):359-62. (PMID: 8735959) ; J Neurosci Res. 2021 Jan;99(1):57-66. (PMID: 32162350) ; Peptides. 1998;19(2):359-63. (PMID: 9493869) ; Mediators Inflamm. 2019 May 15;2019:7898095. (PMID: 31736656) ; Neuropeptides. 2004 Aug;38(4):225-34. (PMID: 15337374) ; Eur J Pharmacol. 2001 Mar 2;414(2-3):215-24. (PMID: 11239922) ; Brain Res. 2011 Aug 17;1407:27-37. (PMID: 21777907) ; Depress Anxiety. 1997;6(1):1-9. (PMID: 9394869) ; Int J Neuropsychopharmacol. 2020 Dec 29;23(12):783-790. (PMID: 33009815) ; Am J Psychiatry. 1999 Dec;156(12):1895-901. (PMID: 10588402) ; Neuropeptides. 2017 Aug;64:39-45. (PMID: 28196617) ; PLoS One. 2018 Jan 29;13(1):e0191794. (PMID: 29377906) ; J Chem Neuroanat. 2009 Dec;38(4):266-72. (PMID: 19505571) ; Nature. 2018 Apr;556(7702):520-524. (PMID: 29670288) ; Brain Res. 2010 Feb 16;1314:194-205. (PMID: 19782662) ; Psychopharmacology (Berl). 2008 Jan;195(4):547-57. (PMID: 17891380) ; Behav Pharmacol. 1995 Apr;6(3):215-222. (PMID: 11224329) ; Brain Res Gene Expr Patterns. 2001 Aug;1(1):17-21. (PMID: 15018814) ; J Neurochem. 1992 Jul;59(1):73-80. (PMID: 1613514) ; Neurosci Lett. 1999 Apr 23;265(3):191-4. (PMID: 10327163) Grant Information: R01 MH098554 United States MH NIMH NIH HHS; R01 MH106565 United States MH NIMH NIH HHS Contributed Indexing: Keywords: Depression; Hippocampus; Neuropeptide Y; Prefrontal cortex; Suicide Substance Nomenclature: 0 (Neuropeptide Y) ; 0 (RNA, Messenger) ; 0 (Receptors, Neuropeptide Y) Entry Date(s): Date Created: 20210819 Date Completed: 20220214 Latest Revision: 20230111 Update Code: 20240513 PubMed Central ID: PMC8489679

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Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study.