Racial/ethnic differences in postmenopausal breast cancer risk by hormone receptor status: The multiethnic cohort study.
In: International journal of cancer, Jg. 150 (2022-01-15), Heft 2, S. 221-231
Online
academicJournal
Zugriff:
There are racial/ethnic differences in the incidence of hormone receptor positive and negative breast cancer. To understand why these differences exist, we investigated associations between hormone-related factors and breast cancer risk by race/ethnicity in the Multiethnic Cohort (MEC) Study. Among 81 511 MEC participants (Native Hawaiian, Japanese American, Latina, African American and White women), 3806 estrogen receptor positive (ER+) and 828 ER- incident invasive breast cancers were diagnosed during a median of 21 years of follow-up. We used Cox proportional hazards regression models to calculate associations between race/ethnicity and breast cancer risk, and associations between hormone-related factors and breast cancer risk by race/ethnicity. Relative to White women, ER+ breast cancer risk was higher in Native Hawaiians and lower in Latinas and African Americans; ER- disease risk was higher in African Americans. We observed interaction with race/ethnicity in associations between oral contraceptive use (OC; P int .03) and body mass index (BMI; P int .05) with ER+ disease risk; ever versus never OC use increased risk only in Latinas and positive associations for obese versus lean BMI were strongest in Japanese Americans. For ER- disease risk, associations for OC use, particularly duration of use, were strongest for African Americans (P int .04). Our study shows that associations of OC use and obesity with ER+ and ER- breast cancer risk differ by race/ethnicity, but established risk factors do not fully explain racial/ethnic differences in risk. Further studies are needed to identify factors to explain observed racial/ethnic differences in breast cancer incidence.
(© 2021 UICC.)
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Racial/ethnic differences in postmenopausal breast cancer risk by hormone receptor status: The multiethnic cohort study.
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Autor/in / Beteiligte Person: | Sarink, D ; White, KK ; Loo, LWM ; Wu, AH ; Wilkens, LR ; Le Marchand, L ; Park, SY ; Setiawan, VW ; Merritt, MA |
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Zeitschrift: | International journal of cancer, Jg. 150 (2022-01-15), Heft 2, S. 221-231 |
Veröffentlichung: | 1995- : New York, NY : Wiley-Liss ; <i>Original Publication</i>: 1966-1984 : Genève : International Union Against Cancer, 2022 |
Medientyp: | academicJournal |
ISSN: | 1097-0215 (electronic) |
DOI: | 10.1002/ijc.33795 |
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