Activation of 5-HT <subscript>1</subscript> receptor in lateral habenula impaired contextual fear memory and hippocampal LTP in rat.

Gu, J ; Hou, Z ; et al.

In: Neuroscience letters, Jg. 770 (2022-01-23), S. 136305

academicJournal

Serotonin (5-hydroxytraptamine, 5-HT) is a neurotransmitter plays important roles in emotion and motivation. The action of 5-HT varies across nucleus and the receptor sub-types. Lateral habenula (LHb) in a brain area reciprocally connects with raphe nucleus and plays important roles in emotion and depression. In this study, we aimed to study the role of 5-HT 1 receptor in LHb on fear learning. 15 min before or immediate after the fear conditioning, 5-Carboxyamidotrypamine maleate salt (5-CT), an agonist of 5-HT 1 receptor, was bilaterally delivered into LHb (1 μg/μl, 1 μl/side) in rats. We found that activation of 5-HT 1 receptor in LHb impaired the acquisition but not consolidation of fear memory in rats, which was accompanied by impaired long-term potentiation (LTP) and decreased phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subunit 1 (GluA1) at the Ser845 site in hippocampus. In addition, 5-CT decreased the time spent in center area of the open field and time spent in open arm in elevated plus maze. These results suggest that activation of 5-HT 1 receptor in LHb impaired acquisition of hippocampal dependent fear memory and increased anxiety- like behavior in rats.

Titel:	Activation of 5-HT <subscript>1</subscript> receptor in lateral habenula impaired contextual fear memory and hippocampal LTP in rat.
Autor/in / Beteiligte Person:	Gu, J ; Hou, Z ; Zhou, X ; Wang, Q ; Chen, Y ; Zhang, J
Zeitschrift:	Neuroscience letters, Jg. 770 (2022-01-23), S. 136305
Veröffentlichung:	Limerick : Elsevier Scientific Publishers Ireland ; <i>Original Publication</i>: Amsterdam, Elsevier/North-Holland., 2022
Medientyp:	academicJournal
ISSN:	1872-7972 (electronic)
DOI:	10.1016/j.neulet.2021.136305
Schlagwort:	Animals Fear Habenula drug effects Habenula physiology Hippocampus drug effects Hippocampus physiology Male Maze Learning Rats Rats, Sprague-Dawley Receptors, AMPA metabolism Serotonin 5-HT1 Receptor Agonists pharmacology Habenula metabolism Hippocampus metabolism Long-Term Potentiation Memory Receptors, Serotonin, 5-HT1 metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Neurosci Lett] 2022 Jan 23; Vol. 770, pp. 136305. <i>Date of Electronic Publication: </i>2021 Oct 23. MeSH Terms: Long-Term Potentiation* ; Memory* ; Habenula / metabolism ; Hippocampus / metabolism ; Receptors, Serotonin, 5-HT1 / *metabolism ; Animals ; Fear ; Habenula / drug effects ; Habenula / physiology ; Hippocampus / drug effects ; Hippocampus / physiology ; Male ; Maze Learning ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA / metabolism ; Serotonin 5-HT1 Receptor Agonists / pharmacology Contributed Indexing: Keywords: Fear conditioning; Lateral Habenula; Long-Term potentiation; Serotonin receptor Substance Nomenclature: 0 (Receptors, AMPA) ; 0 (Receptors, Serotonin, 5-HT1) ; 0 (Serotonin 5-HT1 Receptor Agonists) ; TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1) Entry Date(s): Date Created: 20211026 Date Completed: 20220315 Latest Revision: 20220315 Update Code: 20240513

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