New Cu(II) coordination polymer inhibits cervical cancer development by regulating BRCA1 protein via miR-9-5p.
In: Journal of inorganic biochemistry, Jg. 226 (2022), S. 111655
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Zugriff:
A novel Cu(II)-based coordination polymer [chemical composition, {[CuL(CH 3 CO 2 )](H 2 O)(DMF)} n (1, DMF = N,N-dimethylformamide) was successfully prepared via Cu(NO 3 ) 2 ·3H 2 O reaction with HL ligand in DMF and H 2 O mixture by using a hetero-donor ligand 4-(bis(4-(4H-1,2,4-triazol-4-yl)phenyl)amino)benzoic acid (HL) featuring carboxylic acid and triazole groups. Reverse transcription-polymerase chain reaction (RT-PCR) was adopted to determine miR-9-5p expression in cervical cancer cells after compound treatment. Bioinformatic analysis and luciferase reporter assay were utilized to confirm miR-9-5p and BRCA1 interaction to discover the potential goal of miR-9-5p in cervical cancer cells. Cell Counting Kit-8 (CCK-8) and reactive oxygen species (ROS) detection kits were adopted to examine cancer cell proliferation and ROS accumulation after compound treatment.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Titel: |
New Cu(II) coordination polymer inhibits cervical cancer development by regulating BRCA1 protein via miR-9-5p.
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Autor/in / Beteiligte Person: | Zhang, L ; Li, WP |
Zeitschrift: | Journal of inorganic biochemistry, Jg. 226 (2022), S. 111655 |
Veröffentlichung: | New York, Elsevier., 2022 |
Medientyp: | academicJournal |
ISSN: | 1873-3344 (electronic) |
DOI: | 10.1016/j.jinorgbio.2021.111655 |
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