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Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.

Winning, L ; El Karim, IA ; et al.
In: Journal of periodontal research, Jg. 57 (2022), Heft 1, S. 186-194
Online academicJournal

Titel:
Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
Autor/in / Beteiligte Person: Winning, L ; El Karim, IA ; Linden, GJ ; Irwin, CR ; Killough, SA ; Lundy, FT
Link:
Zeitschrift: Journal of periodontal research, Jg. 57 (2022), Heft 1, S. 186-194
Veröffentlichung: Malden, MA : Wiley-Blackwell ; <i>Original Publication</i>: Copenhagen : Munksgaard International Publishers, 2022
Medientyp: academicJournal
ISSN: 1600-0765 (electronic)
DOI: 10.1111/jre.12952
Schlagwort:
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Gene Expression
  • Humans
  • Neuropeptide Y genetics
  • Osteogenesis
  • Stem Cells
  • Substance P
  • Cytokines
  • Periodontal Ligament
  • Receptors, Neurokinin-1 metabolism
  • Receptors, Neuropeptide Y metabolism
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article
  • Language: English
  • [J Periodontal Res] 2022 Jan; Vol. 57 (1), pp. 186-194. <i>Date of Electronic Publication: </i>2021 Nov 13.
  • MeSH Terms: Cytokines* ; Periodontal Ligament* ; Receptors, Neurokinin-1 / *metabolism ; Receptors, Neuropeptide Y / *metabolism ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Gene Expression ; Humans ; Neuropeptide Y / genetics ; Osteogenesis ; Stem Cells ; Substance P
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Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis. J Biol Chem. 2007;282(26):19092-19102. ; Jana B, Całka J, Palus K. Inflammation changes the expression of neuropeptide Y receptors in the pig myometrium and their role in the uterine contractility. PLoS One. 2020;15(7):e0236044. ; Eapen PM, Rao CM, Nampoothiri M. Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders. Rev Neurosci. 2019;30(3):233-243. ; Divaris K, Monda KL, North KE, et al. Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Hum Mol Genet. 2013;22(11):2312-2324. ; Freitag-Wolf S, Dommisch H, Graetz C, et al. Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men. J Clin Periodontol. 2014;41(12):1115-1121. ; Lundy FT, El Karim IA, Linden GJ. Neuropeptide Y (NPY) and NPY Y1 receptor in periodontal health and disease. 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Neuropeptide Y Y1 receptor antagonist PD160170 promotes osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro and femoral defect repair in rats. Nan Fang Yi Ke Da Xue Xue Bao. 2018;38(6):669-676. ; Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000. 1997;14(1):9-11. ; Nilsson BO. Mechanisms involved in regulation of periodontal ligament cell production of pro-inflammatory cytokines: Implications in periodontitis. J Periodontal Res. 2021;56(2):249-255. ; Ji RR, Zhang X, Wiesenfeld-Hallin Z, Hokfelt T. Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation. J Neurosci. 1994;14(11 Pt 1):6423-6434. ; Franquinho F, Liz MA, Nunes AF, Neto E, Lamghari M, Sousa MM. Neuropeptide Y and osteoblast differentiation - the balance between the neuro-osteogenic network and local control. FEBS J. 2010;277(18):3664-3674. ; Sousa DM, Herzog H, Lamghari M. NPY signalling pathway in bone homeostasis: Y1 receptor as a potential drug target. Curr Drug Targets. 2009;10(1):9-19. ; Rosen CJ. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab. 2008;7(1):7-10. ; Birmingham E, Niebur GL, McHugh PE, Shaw G, Barry FP, McNamara LM. Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche. Eur Cells Mater. 2012;23:13-27. ; Liu S, Jin D, Wu JQ, et al. Neuropeptide Y stimulates osteoblastic differentiation and VEGF expression of bone marrow mesenchymal stem cells related to canonical Wnt signaling activating in vitro. Neuropeptides. 2016;56:105-113. ; Gu XC, Zhang XB, Hu B, Zi Y, Li M. Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells. Neuropeptides. 2016;60:61-66. ; Zhang B, Zhang X, Xiao J, Zhou X, Chen Y, Gao C. Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3-E1 cells via an autocrine mechanism. Mol Med Rep. 2020;22(5):4376-4382. ; Bedoui S, Miyake S, Lin Y, et al. Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY1 receptor-specific inhibition of autoreactive Th1 responses in vivo. J Immunol (Baltimore, Md: 1950). 2003;171(7):3451-3458. ; Zukowska-Grojec Z, Karwatowska-Prokopczuk E, Rose W, et al. Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. Circ Res. 1998;83(2):187-195. ; Zukowska Z, Grant DS, Lee EW. Neuropeptide Y: a novel mechanism for ischemic angiogenesis. Trends Cardiovasc Med. 2003;13(2):86-92. ; El Karim IA, Linden GJ, Orr DF, Lundy FT. Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J Neuroimmunol. 2008;200(1-2):11-16. ; Fu S, Mei G, Wang Z, et al. Neuropeptide substance P improves osteoblastic and angiogenic differentiation capacity of bone marrow stem cells in vitro. Biomed Res Int. 2014;2014:10. ; Mori T, Ogata T, Okumura H, Shibata T, Nakamura Y, Kataoka K. Substance P regulates the function of rabbit cultured osteoclast; Increase of intracellular free calcium concentration and enhancement of bone resorption. Biochem Biophys Res Comm. 1999;262(2):418-422. ; Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE, O'Connor KC. In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells (Dayton, Ohio). 2010;28(4):788-798. ; Waddington RJ, Youde SJ, Lee CP, Sloan AJ. Isolation of distinct progenitor stem cell populations from dental pulp. Cells Tissues Organs. 2009;189(1-4):268-274. ; Sullivan LM, Weinberg J, Keaney JF Jr. Common statistical pitfalls in basic science research. 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  • Grant Information: British Society of Periodontology
  • Contributed Indexing: Keywords: neurogenic inflammation; neuropeptide Y; osteoblastic differentiation; periodontal ligament stem cells; substance P
  • Substance Nomenclature: 0 (Cytokines) ; 0 (Neuropeptide Y) ; 0 (Receptors, Neurokinin-1) ; 0 (Receptors, Neuropeptide Y) ; 0 (neuropeptide Y-Y1 receptor) ; 33507-63-0 (Substance P)
  • Entry Date(s): Date Created: 20211113 Date Completed: 20220118 Latest Revision: 20220531
  • Update Code: 20240513

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