Efficacy and safety of convalescent plasma therapy in patients with moderate-to-severe COVID-19: A non-randomized comparative study with historical control in a referral hospital in Indonesia.
In: Journal of infection and public health, Jg. 15 (2022), Heft 1, S. 100-108
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Zugriff:
Background: Studies to confirm the efficacy and safety of convalescent plasma (CP) as an adjunctive treatment for COVID-19 are still required especially for the countries where standard treatments are unevenly distributed.
Methods: A non-randomized comparative study was done from June - September 2020 in Dr. Sardjito Hospital, Yogyakarta, Indonesia. Plasma with anti-SARS-CoV-2 specific IgG titer of >1:320 were used. Primary end points were clinical and laboratory parameters outcome including BGA, chest X-ray, CT value, CRP, procalcitonin, IL-6, D-Dimer and ALC examined on day 1, 2 and 7 post-transfusion.
Results: The experimental arm of this study consisted of 15 patients who received CP: 3 (20%) with moderate COVID-19 and 12 (80%) with severe COVID-19. There were 15 historical controls in this study. Ten recipients survived and 5 deceased (survival rate was 66.7%). There were higher rate of pneumonia resolution (OR 1.54, CI95% 0.33-7.23), ARDS resolution (OR 1.20, CI95% 0.25-5.84) and shorter median length of stay (20 vs 22 days, p = 0.41) among recipients compared to controls. Lower mortality rate was observed in recipients vs controls (33.3% vs 46.7% (OR 0.75, CI95% 0.17-3.33)). Median death onset was longer in recipient vs control (7 th vs 1 st day, p = 0.13). Survival analysis showed protective effect of CP (HR 0.69, CI 95% 0.21-2.27, p = 0.545). Higher CT value improvement (p = 0.51) and negative conversion rate (OR1.20, CI95% 0.25-5.84) were observed in recipients compared to controls. Sub-analysis showed more number of comorbidities, higher procalcitonin and higher D-Dimer among CP recipients who did not survive (p = 0.02 and p = 0.02 respectively). Lower CRP and procalcitonin, and higher ALC were found in survivors compared to non-survivors (p = 0.0437; p = 0.0049; and p = 0.0002 respectively).
Conclusion: This study showed promising results for CP marked by improvements in clinical outcome, as well as significant reduction of inflammatory markers among recipients.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
| Titel: |
Efficacy and safety of convalescent plasma therapy in patients with moderate-to-severe COVID-19: A non-randomized comparative study with historical control in a referral hospital in Indonesia.
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| Autor/in / Beteiligte Person: | Kurnianda, J ; Hardianti, MS ; Triyono, T ; Thobari, JA ; Trisnawati, I ; Wisudarti, CFR ; Sukorini, U ; Anshori, F ; Setiawan, SA ; Ucche, M ; Farahnaz, A ; Suryani, Y |
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| Zeitschrift: | Journal of infection and public health, Jg. 15 (2022), Heft 1, S. 100-108 |
| Veröffentlichung: | Oxford : Elsevier, 2008-, 2022 |
| Medientyp: | academicJournal |
| ISSN: | 1876-035X (electronic) |
| DOI: | 10.1016/j.jiph.2021.10.028 |
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