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Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD. In 4354 participants (76 ± 5 years; 58% female) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we identified five LLD symptom profiles, based on the Geriatric Depression Scale-15 (no LLD (57%); apathy (31%); apathy with emptiness (2%), mild LLD (8%) and severe LLD (2%)). Cox regression analyses showed that severe LLD, mild LLD and apathy increased risk of dementia up to 12 years, compared to no LLD. Additionally, hippocampal volume loss and white matter lesion increase, were assessed on 1.5 T MR images, at baseline and after 5 years follow-up. Only severe LLD showed increased WML volume over time, but not on hippocampal volume loss. WML increase over time mediated partially the relation between mild LLD and dementia but not for the other symptom profiles. It appears that hippocampal atrophy and LLD are independent predictors for dementia incidence, whereas for mild LLD the risk for dementia is partially mediated by WML changes.

Titel:	Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study.
Autor/in / Beteiligte Person:	Gerritsen, L ; Sigurdsson, S ; Jonsson, PV ; Gudnason, V ; Launer, LJ ; Geerlings, MI
Zeitschrift:	Neurobiology of aging, Jg. 111 (2022-03-01), S. 14-23
Veröffentlichung:	New York : Elsevier ; <i>Original Publication</i>: Fayetteville, N.Y. : Ankho International., 2022
Medientyp:	academicJournal
ISSN:	1558-1497 (electronic)
DOI:	10.1016/j.neurobiolaging.2021.09.025
Schlagwort:	Aged Aged, 80 and over Apathy Dementia genetics Depression psychology Female Forecasting Gene-Environment Interaction Humans Male Organ Size Patient Acuity Aging pathology Dementia etiology Dementia pathology Depression complications Depression pathology Hippocampus pathology White Matter pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Neurobiol Aging] 2022 Mar; Vol. 111, pp. 14-23. <i>Date of Electronic Publication: </i>2021 Nov 27. MeSH Terms: Aging / pathology ; Dementia / etiology ; Dementia / pathology ; Depression / complications ; Depression / pathology ; Hippocampus / pathology ; White Matter / *pathology ; Aged ; Aged, 80 and over ; Apathy ; Dementia / genetics ; Depression / psychology ; Female ; Forecasting ; Gene-Environment Interaction ; Humans ; Male ; Organ Size ; Patient Acuity References: Arch Gen Psychiatry. 1997 Oct;54(10):915-22. (PMID: 9337771) ; J Am Geriatr Soc. 2014 Jan;62(1):130-4. (PMID: 25093232) ; Am J Psychiatry. 2002 Aug;159(8):1424-7. (PMID: 12153839) ; Am J Geriatr Psychiatry. 2009 Apr;17(4):344-52. (PMID: 19307863) ; Am J Geriatr Psychiatry. 2014 Dec;22(12):1469-77. (PMID: 24211028) ; Alzheimers Dement. 2017 Apr;13(4):406-418. (PMID: 27599208) ; Int J Geriatr Psychiatry. 2008 Oct;23(10):1040-50. (PMID: 18412291) ; Front Aging Neurosci. 2018 Feb 20;10:40. (PMID: 29515435) ; Transl Psychiatry. 2017 May 2;7(5):e1117. (PMID: 28463236) ; Psychol Med. 2015 Jul;45(9):1931-44. (PMID: 25896060) ; J Alzheimers Dis. 2015;46(1):63-73. (PMID: 25697700) ; Biol Psychiatry. 2017 Sep 1;82(5):339-350. (PMID: 28318491) ; Neurology. 2018 Jan 2;90(1):e82-e89. (PMID: 29196576) ; Neurology. 2014 May 6;82(18):1628-35. (PMID: 24739783) ; Nat Rev Neurol. 2011 May 03;7(6):323-31. (PMID: 21537355) ; Neurology. 2008 Apr 8;70(15):1258-64. (PMID: 18391157) ; Am J Alzheimers Dis Other Demen. 2002 Nov-Dec;17(6):338-44. (PMID: 12501480) ; Ann N Y Acad Sci. 1997 Jun 21;821:271-84. (PMID: 9238211) ; Aging Ment Health. 2019 Jul;23(7):819-830. (PMID: 29381390) ; J Int Neuropsychol Soc. 2018 Mar;24(3):269-282. (PMID: 29032789) ; Psychiatr Clin North Am. 2011 Jun;34(2):377-401, viii. (PMID: 21536164) ; Am J Geriatr Psychiatry. 2009 May;17(5):387-96. (PMID: 19390296) ; Curr Opin Neurol. 2013 Dec;26(6):656-61. (PMID: 24184971) ; J Psychiatr Res. 2016 Nov;82:1-7. (PMID: 27447786) ; J Clin Psychiatry. 2007;68 Suppl 8:4-10. (PMID: 17640152) ; Neuroimage. 2012 Feb 15;59(4):3862-3870. (PMID: 22119006) ; Lancet Neurol. 2013 Feb;12(2):207-16. (PMID: 23332364) ; J Geriatr Psychiatry Neurol. 2021 Jan;34(1):21-28. (PMID: 32036772) ; Can J Neurol Sci. 2016 Apr;43 Suppl 1:S3-S50. (PMID: 27307127) ; Am J Geriatr Psychiatry. 2014 Feb;22(2):167-76. (PMID: 23567441) ; Mol Psychiatry. 2013 Sep;18(9):963-74. (PMID: 23439482) ; Neurology. 2019 Mar 12;92(11):e1157-e1167. (PMID: 30737341) ; Psychoneuroendocrinology. 2005 Apr;30(3):225-42. (PMID: 15511597) ; BMJ Open. 2015 Dec 21;5(12):e008853. (PMID: 26692556) ; Psychiatry Res. 1997 Aug 8;71(3):181-95. (PMID: 9271791) ; Int J Geriatr Psychiatry. 2012 Oct;27(10):1061-9. (PMID: 22135008) ; Acta Psychiatr Scand. 2018 Jun;137(6):491-502. (PMID: 29457245) ; Hippocampus. 2019 Jun;29(6):500-510. (PMID: 30307080) ; Am J Psychiatry. 2004 Nov;161(11):1957-66. (PMID: 15514393) ; Psychiatry Res. 2018 Aug;266:228-246. (PMID: 29605104) ; Am J Geriatr Psychiatry. 2019 Aug;27(8):873-882. (PMID: 30910421) ; Biol Psychiatry. 2013 Jan 15;73(2):169-76. (PMID: 23079234) ; Aging Ment Health. 2013;17(5):638-45. (PMID: 23339600) Grant Information: HHSN271201200022C United States DA NIDA NIH HHS; N01AG12100 United States AG NIA NIH HHS; ZIA AG007480 United States ImNIH Intramural NIH HHS Contributed Indexing: Keywords: Alzheimer's disease; dementia; hippocampus; late-life depression; white matter lesions Entry Date(s): Date Created: 20211219 Date Completed: 20220221 Latest Revision: 20240516 Update Code: 20240516 PubMed Central ID: PMC11095503

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Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study.