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This study analyzed the clinical features and molecular characteristics of methicillin-susceptible Staphylococcus aureus (MSSA) ocular infections in Taiwan and compared them between community-associated (CA) and health-care-associated (HA) infections. We collected S. aureus ocular isolates from patients at Chang Gung Memorial Hospital between 2010 and 2017. The infections were classified as CA or HA using epidemiological criteria, and the isolates were molecularly characterized using pulsed-field gel electrophoresis, multilocus sequence typing, and Panton-Valentine leukocidin (PVL) gene detection. Antibiotic susceptibility was evaluated using disk diffusion and an E test. A total of 104 MSSA ocular isolates were identified; 46 (44.2%) were CA-MSSA and 58 (55.8%) were HA-MSSA. Compared with HA-MSSA strains, CA-MSSA strains caused a significantly higher rate of keratitis, but a lower rate of conjunctivitis. We identified 14 pulsotypes. ST 7/pulsotype BA was frequently identified in both CA-MSSA (28.3%) and HA-MSSA (37.9%) cases. PVL genes were identified in seven isolates (6.7%). Both CA-MSSA and HA-MSSA isolates were highly susceptible to vancomycin, teicoplanin, tigecycline, sulfamethoxazole-trimethoprim, and fluoroquinolones. The most common ocular manifestations were keratitis and conjunctivitis for CA-MSSA and HA-MSSA, respectively. The MSSA ocular isolates had diverse molecular characteristics; no specific genotype differentiated CA-MSSA from HA-MSSA. Both strains exhibited similar antibiotic susceptibility.

Titel:	Clinical Features and Molecular Characteristics of Methicillin-Susceptible Staphylococcus aureus Ocular Infection in Taiwan.
Autor/in / Beteiligte Person:	Chen, YL ; Kang, EY ; Yeh, LK ; Ma, DHK ; Tan, HY ; Chen, HC ; Hung, KH ; Huang, YC ; Hsiao, CH
Link:	Full Text Finder (Volltext)
Zeitschrift:	Antibiotics (Basel, Switzerland), Jg. 10 (2021-11-25), Heft 12
Veröffentlichung:	Basel, Switzerland : MDPI AG, 2012-, 2021
Medientyp:	academicJournal
ISSN:	2079-6382 (print)
DOI:	10.3390/antibiotics10121445
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Antibiotics (Basel)] 2021 Nov 25; Vol. 10 (12). <i>Date of Electronic Publication: </i>2021 Nov 25. References: J Clin Microbiol. 2000 Mar;38(3):1008-15. (PMID: 10698988) ; Cornea. 2020 Nov;39(11):1415-1418. (PMID: 32452982) ; Diagn Microbiol Infect Dis. 2012 Dec;74(4):363-8. (PMID: 23021064) ; MMWR Morb Mortal Wkly Rep. 2019 Mar 08;68(9):214-219. (PMID: 30845118) ; PLoS One. 2012;8(8):e42437. (PMID: 22880135) ; BMC Infect Dis. 2019 May 10;19(1):402. (PMID: 31077140) ; J Hosp Infect. 2006 Feb;62(2):241. (PMID: 16289455) ; Clin Microbiol Infect. 2013 Sep;19(9):860-8. (PMID: 23039210) ; mSphere. 2016 Jun 08;1(3):. (PMID: 27303750) ; BMC Infect Dis. 2012 Dec 10;12:343. (PMID: 23228040) ; J Clin Microbiol. 2008 Sep;46(9):2842-7. (PMID: 18614654) ; Ophthalmology. 2012 Mar;119(3):522-7. (PMID: 22176801) ; Acta Ophthalmol. 2020 Mar;98(2):e178-e180. (PMID: 31486592) ; N Engl J Med. 2018 Nov 1;379(18):1732-1744. (PMID: 30380384) ; JAMA Ophthalmol. 2020 May 1;138(5):439-450. (PMID: 32271355) ; Clin Infect Dis. 1999 Nov;29(5):1128-32. (PMID: 10524952) ; J Microbiol Immunol Infect. 2016 Jun;49(3):363-70. (PMID: 25305708) ; Medicine (Baltimore). 2015 Oct;94(42):e1620. (PMID: 26496268) ; Infect Drug Resist. 2019 Apr 11;12:831-843. (PMID: 31043797) ; Clin Infect Dis. 2020 Mar 3;70(6):1021-1028. (PMID: 31245810) ; Eur J Ophthalmol. 2019 Nov;29(6):673-677. (PMID: 30295039) ; Cornea. 1996 Jan;15(1):66-71. (PMID: 8907383) ; Medicine (Baltimore). 2015 Feb;94(5):e474. (PMID: 25654386) ; Clin Epidemiol. 2018 Oct 12;10:1489-1501. (PMID: 30349396) ; Curr Eye Res. 2011 Feb;36(2):94-102. (PMID: 21158584) ; Nat Rev Microbiol. 2019 Apr;17(4):203-218. (PMID: 30737488) ; Diagn Microbiol Infect Dis. 2009 Dec;65(4):351-7. (PMID: 19766426) ; Cornea. 1989;8(2):115-21. (PMID: 2714094) ; Int J Microbiol. 2020 Oct 29;2020:8831322. (PMID: 33488725) ; Am J Ophthalmol. 2004 Mar;137(3):453-8. (PMID: 15013867) ; Am J Ophthalmol. 2008 Jun;145(6):951-958. (PMID: 18374299) Grant Information: CMRPG1 I0021 Linkou Chang Gung Memorial Hospital Contributed Indexing: Keywords: MSSA; Panton-Valentine leukocidin; Staphyloccus aureus; antibiotic resistance; multilocus sequence typing; ocular infection; pulsed-field gel electrophoresis Entry Date(s): Date Created: 20211224 Latest Revision: 20211228 Update Code: 20240513 PubMed Central ID: PMC8698105

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Clinical Features and Molecular Characteristics of Methicillin-Susceptible Staphylococcus aureus Ocular Infection in Taiwan.