Fructooligosaccharides on inflammation, immunomodulation, oxidative stress, and gut immune response: a systematic review.

Costa, GT ; Vasconcelos, QDJS ; et al.

In: Nutrition reviews, Jg. 80 (2022-03-10), Heft 4, S. 709-722

academicJournal

Context: Evidence shows that fructooligosaccharides (FOSs) can modulate inflammatory, oxidative, and immune activity in the gut, possibly leading to a systemic response, improving human health.

Objective: To assess the present knowledge of the effects of FOSs on inflammation, immunomodulation, oxidative stress, and gut immune response.

Data Sources: Studies published between December 2000 and January 2020 were systematically searched in four databases: MEDLINE, LILACS, Web of Science, and Scopus. After the screening of 1316 articles, 8 human studies and 20 animal models were included.

Data Extraction: Data were extracted separately by 2 reviewers. For each study, the design, population, exposures, main results, and conclusion were extracted. The research questions and the risk-of-bias information were also extracted. Additionally, the risk-of-bias were analyzed to guarantee the reliability of this review.

Data Analysis: A qualitative analysis revealed that FOSs can increase bifidobacteria counts and short-chain fatty acids in the gut, stimulate IgA secretion in the colon, and decrease proinflammatory cytokines, thus influencing metabolic diseases.

Conclusion: Studies suggest that FOS supplementation is positively associated with an anti-inflammatory and antioxidant effect, thus enhancing the gut immune system, which may be beneficial for the host's health.

Systematic Review Registration: PROSPERO registration nos 42020209865 and 42020220369.

Titel:	Fructooligosaccharides on inflammation, immunomodulation, oxidative stress, and gut immune response: a systematic review.
Autor/in / Beteiligte Person:	Costa, GT ; Vasconcelos, QDJS ; Aragão, GF
Zeitschrift:	Nutrition reviews, Jg. 80 (2022-03-10), Heft 4, S. 709-722
Veröffentlichung:	2015- : Oxford Oxford University Press ; <i>Original Publication</i>: [Washington, D.C.] : International Life Sciences Institute, 2022
Medientyp:	academicJournal
ISSN:	1753-4887 (electronic)
DOI:	10.1093/nutrit/nuab115
Schlagwort:	Animals Humans Immunity Oligosaccharides Oxidative Stress Reproducibility of Results Immunomodulation Inflammation
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Systematic Review Language: English [Nutr Rev] 2022 Mar 10; Vol. 80 (4), pp. 709-722. MeSH Terms: Immunomodulation* ; Inflammation* ; Animals ; Humans ; Immunity ; Oligosaccharides ; Oxidative Stress ; Reproducibility of Results Contributed Indexing: Keywords: fructooligosaccharides; gut immune response; immunomodulation; inflammation; oxidative stress* Substance Nomenclature: 0 (Oligosaccharides) ; 0 (fructooligosaccharide) Entry Date(s): Date Created: 20211230 Date Completed: 20220330 Latest Revision: 20220429 Update Code: 20240513

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