[Severe Covid-19 comprises a self-amplifying loop of inflammation and coagulopathy].
In: Lakartidningen, Jg. 119 (2022-01-07)
Online
academicJournal
Zugriff:
Severe Covid-19 has a high mortality rate. Vital organ dysfunction results from pathophysiological self-amplifying loops of innate immunological hyperactivation, cytokine release, complement deposition, endothelial damage, and macro- and microvascular thromboembolism. Resulting alveolar exudation and pulmonary capillary thromboembolism lead to ventilation-perfusion mismatch, considered to be a primary cause of death in severe Covid-19. Therapeutic immunomodulation is believed to be safer and more effective during time periods with decreasing viral exposition and increasing inflammation.
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[Severe Covid-19 comprises a self-amplifying loop of inflammation and coagulopathy].
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Autor/in / Beteiligte Person: | Loo, K ; Åkeson, J |
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Zeitschrift: | Lakartidningen, Jg. 119 (2022-01-07) |
Veröffentlichung: | Stockholm : Sveriges Lakarforbund, 2022 |
Medientyp: | academicJournal |
ISSN: | 1652-7518 (electronic) |
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