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Cardio-cerebrovascular disease (CCVD) has become the leading cause of human mortality with the coming acceleration of global population aging. Atherosclerosis is among the most common pathological changes in CCVDs. It is also a multifactorial disorder; oxidative stress caused by excessive production of reactive oxygen species (ROS) has become an important mechanism of atherosclerosis. Chinese herbal medicine (CHM) is a major type of natural medicine that has made great contributions to human health. CHMs are increasingly used in the auxiliary clinical treatment of atherosclerosis. Although their mechanism of action is unclear, CHMs can exert a variety of antiatherosclerosis effects by regulating intracellular ROS. In this review, we discussed the mechanism of ROS regulation in atherosclerosis and analyzed the role of CHMs in the treatment of atherosclerosis via ROS.

Competing Interests: The authors declare that the research was conducted in the absence of any commercial of financial relationships that could be constructed as a potential conflict of interest.

Titel:	Targeting Reactive Oxygen Species in Atherosclerosis via Chinese Herbal Medicines.
Autor/in / Beteiligte Person:	Zhang, L ; Huang, J ; Zhang, D ; Lei, X ; Ma, Y ; Cao, Y ; Chang, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Oxidative medicine and cellular longevity, Jg. 2022 (2022-01-10), S. 1852330
Veröffentlichung:	2011- : New York : Hindawi Pub. Corp. ; <i>Original Publication</i>: 2008-2010: Austin, TX : Landes Bioscience, 2022
Medientyp:	academicJournal
ISSN:	1942-0994 (electronic)
DOI:	10.1155/2022/1852330
Schlagwort:	Drugs, Chinese Herbal pharmacology Humans Atherosclerosis drug therapy Drugs, Chinese Herbal therapeutic use Reactive Oxygen Species metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Oxid Med Cell Longev] 2022 Jan 10; Vol. 2022, pp. 1852330. <i>Date of Electronic Publication: </i>2022 Jan 10 (<i>Print Publication: </i>2022). MeSH Terms: Atherosclerosis / drug therapy ; Drugs, Chinese Herbal / therapeutic use ; Reactive Oxygen Species / *metabolism ; Drugs, Chinese Herbal / pharmacology ; Humans References: Biomed Pharmacother. 2019 Apr;112:108639. (PMID: 30784924) ; Phytomedicine. 2021 Jul;87:153577. (PMID: 33994055) ; Curr Opin Hematol. 2018 Jan;25(1):44-51. (PMID: 28914666) ; Biomed Pharmacother. 2018 Jun;102:510-516. (PMID: 29579712) ; Eur J Pharmacol. 2011 Jan 25;651(1-3):152-8. (PMID: 21118684) ; Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1605-12. (PMID: 22580898) ; Pulm Pharmacol Ther. 2009 Dec;22(6):562-6. (PMID: 19665057) ; Mol Aspects Med. 2001 Aug-Oct;22(4-5):189-216. 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(PMID: 28921056) ; Physiol Rev. 2004 Oct;84(4):1381-478. (PMID: 15383655) Substance Nomenclature: 0 (Drugs, Chinese Herbal) ; 0 (Reactive Oxygen Species) Entry Date(s): Date Created: 20220120 Date Completed: 20220308 Latest Revision: 20220308 Update Code: 20231215 PubMed Central ID: PMC8763505

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Targeting Reactive Oxygen Species in Atherosclerosis via Chinese Herbal Medicines.