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Aims: Insulin deficiency (ID) and resistance (IR) contribute to progression from normal glucose tolerance to diabetes to insulin requirement although their relative contributions in young-onset diabetes is unknown.

Methods: We examined the associations of HOMA2 using fasting plasma glucose and C-peptide in Chinese aged 20-50 years with (1) progression to type 2 diabetes (T2D) in participants without diabetes in a community-based cohort (1998-2013) and (2) glycaemic deterioration in patients with T2D in a clinic-based cohort (1995-2014). We defined ID as HOMA2-%B below median and insulin IR as HOMA2-IR above median.

Results: During 10-year follow-up, 62 (17.9%) of 347 community-dwelling participants progressed to T2D. After 8.6 years, 291 (48.1%) of 609 patients with T2D had glycaemic deterioration. At baseline, progressors for T2D had higher HOMA2-IR, while in patients with T2D, progressors for glycaemic deterioration had higher HOMA2-IR and lower HOMA2-%B than non-progressors. The non-ID/IR group and the ID/IR group had an adjusted odds ratios of 2.47 (95% CI: 1.28, 4.94) and 5.36 (2.26, 12.79), respectively, for incident T2D versus the ID/non-IR group. In patients with T2D, 50% of the ID/IR group required insulin at 6.7 years versus around 11 years in the non-ID/IR or ID/non-IR, and more than 15 years in the non-ID/non-IR group. Compared with the latter group, the adjusted hazard ratios were 2.74 (1.80, 4.16) in the ID/non-IR, 2.73 (1.78, 4.19) in the non-ID/IR and 4.46 (2.87, 6.91) in the ID/IR group (p-interaction = 0.049).

Conclusions: In young Chinese adults, IR and ID contributed to progression to T2D and glycaemic deterioration.

Titel:	Associations of the HOMA2-%B and HOMA2-IR with progression to diabetes and glycaemic deterioration in young and middle-aged Chinese.
Autor/in / Beteiligte Person:	Fan, B ; Wu, H ; Shi, M ; Yang, A ; Lau, ESH ; Tam, CHT ; Mao, D ; Lim, CKP ; Kong, APS ; Ma, RCW ; Chow, E ; Luk, AOY ; Chan, JCN
Link:	Full Text Finder (Volltext)
Zeitschrift:	Diabetes/metabolism research and reviews, Jg. 38 (2022-07-01), Heft 5, S. e3525
Veröffentlichung:	Oxford, England : Wiley-Blackwell, c1999-, 2022
Medientyp:	academicJournal
ISSN:	1520-7560 (electronic)
DOI:	10.1002/dmrr.3525
Schlagwort:	Adult Blood Glucose China epidemiology Humans Insulin Insulin, Regular, Human Middle Aged Diabetes Mellitus, Type 2 complications Insulin Resistance
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Diabetes Metab Res Rev] 2022 Jul; Vol. 38 (5), pp. e3525. <i>Date of Electronic Publication: </i>2022 Mar 08. MeSH Terms: Diabetes Mellitus, Type 2* / complications ; Insulin Resistance* ; Adult ; Blood Glucose ; China / epidemiology ; Humans ; Insulin ; Insulin, Regular, Human ; Middle Aged References: Diabetes Care. 2000 Jan;23(1):57-63. (PMID: 10857969) ; PLoS Med. 2020 Feb 20;17(2):e1003052. (PMID: 32078650) ; PLoS Med. 2020 Jul 28;17(7):e1003209. (PMID: 32722720) ; Epidemiology. 1992 Sep;3(5):452-6. (PMID: 1391139) ; Diabetes Care. 2019 Nov;42(11):2022-2031. (PMID: 31530658) ; Diabet Med. 1998 Apr;15(4):297-303. (PMID: 9585394) ; Diabetes Metab J. 2016 Aug;40(4):318-25. (PMID: 27273908) ; Diabetes Metab Res Rev. 2020 May;36(4):e3289. (PMID: 31922637) ; Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839) ; J Clin Endocrinol Metab. 2019 Apr 1;104(4):1131-1140. (PMID: 30445509) ; CMAJ. 2009 Apr 28;180(9):919-26. (PMID: 19398738) ; Acta Diabetol. 2015 Oct;52(5):905-15. (PMID: 25794879) ; Lancet. 2021 Dec 19;396(10267):2019-2082. (PMID: 33189186) ; Diabetes Care. 1998 Dec;21(12):2191-2. (PMID: 9839117) ; Lancet. 2014 Mar 22;383(9922):1068-83. (PMID: 24315620) ; Int J Obes (Lond). 2007 Feb;31(2):254-60. (PMID: 16718283) ; Lancet Diabetes Endocrinol. 2020 Feb;8(2):115-124. (PMID: 31879247) ; Diabetes Care. 2004 Mar;27(3):727-33. (PMID: 14988293) ; Diabetes Care. 2013 Jun;36(6):1789-96. (PMID: 23704681) ; Diabetes Care. 2009 Jan;32 Suppl 1:S13-61. (PMID: 19118286) ; Lancet Diabetes Endocrinol. 2016 Jan;4(1):27-34. (PMID: 26577716) ; Diabet Med. 2013 Jul;30(7):803-17. (PMID: 23413806) ; Diabetes. 1999 Sep;48(9):1779-86. (PMID: 10480608) ; Diabetes Res Clin Pract. 2019 Nov;157:107843. (PMID: 31518657) ; Diabetes Care. 2014;37(3):718-724. (PMID: 24186880) ; Diabetes Care. 2008 Mar;31(3):386-90. (PMID: 18083790) ; Diabetes Care. 2014;37(1):149-57. (PMID: 24356598) ; Diabetologia. 2015 Jan;58(1):87-97. (PMID: 25292440) ; Stat Med. 1996 Feb 28;15(4):361-87. (PMID: 8668867) ; Lancet. 2017 Jun 3;389(10085):2239-2251. (PMID: 28190580) ; Diabetes Metab Res Rev. 2003 Jul-Aug;19(4):329-32. (PMID: 12879411) ; Eur J Epidemiol. 2011 Jun;26(6):433-8. (PMID: 21344323) ; Nutr Diabetes. 2015 Jul 20;5:e173. (PMID: 26192451) ; Metabolism. 1979 Nov;28(11):1086-96. (PMID: 386029) ; Diabet Med. 2017 Dec;34(12):1701-1709. (PMID: 28945282) ; JAMA. 2009 May 27;301(20):2129-40. (PMID: 19470990) ; Diabetes Metab Res Rev. 2022 Jul;38(5):e3525. (PMID: 35174618) ; Am J Med Sci. 2018 Jan;355(1):54-60. (PMID: 29289263) ; Diabet Med. 1998 Apr;15(4):290-6. (PMID: 9585393) ; Diabetes Care. 2004 Jun;27(6):1487-95. (PMID: 15161807) ; Lancet. 2019 Oct 26;394(10208):1519-1529. (PMID: 31542292) ; Lancet Diabetes Endocrinol. 2016 Jan;4(1):2-3. (PMID: 26577717) ; Diabetes Care. 2006 Dec;29(12):2733-4. (PMID: 17130216) Contributed Indexing: Keywords: HOMA2; T2D; beta-cell function; glycaemic deterioration; insulin resistance Substance Nomenclature: 0 (Blood Glucose) ; 0 (Insulin) ; 0 (Insulin, Regular, Human) Entry Date(s): Date Created: 20220217 Date Completed: 20220708 Latest Revision: 20221015 Update Code: 20231215 PubMed Central ID: PMC9542522

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Associations of the HOMA2-%B and HOMA2-IR with progression to diabetes and glycaemic deterioration in young and middle-aged Chinese.