Inter- and Intramolecular Proton Transfer in an Isolated (Cytosine-Guanine)H <superscript>+</superscript> Pair: Direct Evidence from IRMPD Spectroscopy.
In: The journal of physical chemistry. A, Jg. 126 (2022-03-03), Heft 8, S. 1403-1411
academicJournal
Zugriff:
The collision-induced dissociation of the protonated cytosine-guanine pair was studied using tandem mass spectrometry (MS 3 ) coupled to infrared multiple photon dissociation spectroscopy with the free electron laser at Orsay (CLIO) to determine the structure of the CH + and GH + ionic fragments. The results were rationalized with the help of electronic structure calculations at the density functional theory level with the B3LYP/6-311++G(3df,2p) method. Several tautomers of each fragment were identified for the first time, some of which were previously predicted by other authors. In addition, two unexpected and minor tautomers were also found: cytosine keto-imino [CKI(1,2,3,4)H + ] and guanine keto-amino [GKA(1,3,7)H + ]. These results highlight the importance of the DNA base tautomerization assisted by inter- and intramolecular proton or hydrogen transfer within the protonated pairs.
Titel: |
Inter- and Intramolecular Proton Transfer in an Isolated (Cytosine-Guanine)H <superscript>+</superscript> Pair: Direct Evidence from IRMPD Spectroscopy.
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Autor/in / Beteiligte Person: | Cruz-Ortiz, AF ; Jara-Toro, RA ; Aranguren, JP ; Scuderi, D ; Pino, GA |
Zeitschrift: | The journal of physical chemistry. A, Jg. 126 (2022-03-03), Heft 8, S. 1403-1411 |
Veröffentlichung: | Washington, D.C. : American Chemical Society, c1997-, 2022 |
Medientyp: | academicJournal |
ISSN: | 1520-5215 (electronic) |
DOI: | 10.1021/acs.jpca.1c10651 |
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