Einzeltreffer — DigiBib

Cyclic GMP-AMP synthase (cGAS) recognizes double-stranded DNA (dsDNA) derived from invading pathogens and induces an interferon response via activation of the key downstream adaptor protein stimulator of interferon genes (STING). This is the most classic biological function of the cGAS-STING signaling pathway and is critical for preventing pathogenic microorganism invasion. In addition, cGAS can interact with various types of nucleic acids, including cDNA, DNA : RNA hybrids, and circular RNA, to contribute to a diverse set of biological functions. An increasing number of studies have revealed an important relationship between the cGAS-STING signaling pathway and autophagy, cellular senescence, antitumor immunity, inflammation, and autoimmune diseases. This review details the mechanism of action of cGAS as it interacts with different types of nucleic acids, its rich biological functions, and the potential for targeting this pathway to treat various diseases.

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Titel:	A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions.
Autor/in / Beteiligte Person:	Wang, D ; Zhao, H ; Shen, Y ; Chen, Q
Link:	Full Text Finder (Volltext)
Zeitschrift:	Frontiers in immunology, Jg. 13 (2022-02-04), S. 826880
Veröffentlichung:	[Lausanne : Frontiers Research Foundation], 2022
Medientyp:	academicJournal
ISSN:	1664-3224 (electronic)
DOI:	10.3389/fimmu.2022.826880
Schlagwort:	Animals Autoimmune Diseases immunology Autophagy physiology Cellular Senescence DNA metabolism Humans Interferon Type I physiology Signal Transduction physiology Inflammation etiology Membrane Proteins physiology Nucleic Acids classification Nucleotidyltransferases physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review Language: English [Front Immunol] 2022 Feb 04; Vol. 13, pp. 826880. <i>Date of Electronic Publication: </i>2022 Feb 04 (<i>Print Publication: </i>2022). MeSH Terms: Inflammation / etiology ; Membrane Proteins / physiology ; Nucleic Acids / classification ; Nucleotidyltransferases / physiology ; Animals ; Autoimmune Diseases / immunology ; Autophagy / physiology ; Cellular Senescence ; DNA / metabolism ; Humans ; Interferon Type I / physiology ; Signal Transduction / physiology References: Elife. 2019 Dec 06;8:. (PMID: 31808743) ; Nat Rev Cancer. 2020 Apr;20(4):203-217. (PMID: 32161398) ; EMBO Rep. 2020 Apr 3;21(4):e49799. (PMID: 32202065) ; Cell Rep. 2019 Feb 26;26(9):2377-2393.e13. (PMID: 30811988) ; PLoS One. 2013 Oct 07;8(10):e76983. (PMID: 24116191) ; Nat Immunol. 2015 Oct;16(10):1025-33. (PMID: 26343537) ; Mol Cancer Res. 2019 Apr;17(4):974-986. 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A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions.