Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease.
In: Biomedicines, Jg. 10 (2022-04-29), Heft 5
Online
academicJournal
Zugriff:
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (Aβ) aggregates in multiple brain regions, including the hippocampus and cortex. The formation of senile plaques involving tau hyperphosphorylation, fibrillar Aβ, and neurofibrillary tangles (NFTs) is used as a pathological marker of AD and eventually produces aggregation or misfolded protein. Importantly, it has been found that the failure to degrade these aggregate-prone proteins leads to pathological consequences, such as synaptic impairment, cytotoxicity, neuronal atrophy, and memory deficits associated with AD. Recently, increasing evidence has suggested that the autophagy pathway plays a role as a central cellular protection system to prevent the toxicity induced by aggregation or misfolded proteins. Moreover, it has also been revealed that AD-related protein aggresomes could be selectively degraded by autophagosome and lysosomal fusion through the autophagy pathway, which is known as aggrephagy. Therefore, the regulation of autophagy serve as a useful approach to modulate the formation of aggresomes associated with AD. This review focuses on the recent improvements in the application of natural compounds and small molecules as a potential therapeutic approach for AD prevention and treatment via aggrephagy.
Titel: |
Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease.
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Autor/in / Beteiligte Person: | Rahman, MA ; Rahman, MDH ; Mamun-Or-Rashid, ANM ; Hwang, H ; Chung, S ; Kim, B ; Rhim, H |
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Zeitschrift: | Biomedicines, Jg. 10 (2022-04-29), Heft 5 |
Veröffentlichung: | Basel, Switzerland : MDPI AG, [2013]-, 2022 |
Medientyp: | academicJournal |
ISSN: | 2227-9059 (print) |
DOI: | 10.3390/biomedicines10051027 |
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