Transcription Factor AhR, Cytokines IL-6 and IL-22 in Subjects with and without Peri-Implantitis: A Case Control-Study.
In: International journal of environmental research and public health, Jg. 19 (2022-06-17), Heft 12
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Zugriff:
Peri-implantitis is a plaque-associated condition characterized by mucosal inflammation and subsequent progressive loss of supporting bone; it is caused by bacterial biofilm, but the host response triggered by bacterial stimulation promotes the release of cells and mediators that culminate in tissue destruction. The Aryl-hydrocarbon Receptor (AhR) is associated with IL-22 production by Th22 and Th17 CD4+ Th cells. The presence of IL-6 may promote the Th22 phenotype. The present case-control study evaluated the gene expression of AhR, IL-22, and IL-6 in the peri-implant tissues of healthy and peri-implantitis patients. Tissue biopsies were collected from thirty-five volunteers (15 healthy and 20 with peri-implantitis). A real-time PCR reaction was utilized to assess the AhR, IL-22, and IL-6 gene expression levels relative to the reference gene (GAPDH). The results were analyzed using the Mann-Whitney test with a significance level of 5%. Higher levels of gene expression of AhR and IL-6 were detected in peri-implantitis tissues. The IL-22 gene expression levels did not differ between groups. In conclusion, higher gene expression levels for AhR and IL-6 were detected in the soft tissues of peri-implantitis patients. IL-22 did not vary between conditions, which may indicate the loss of the immunomodulatory role of IL-22 in periimplantitis.
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Transcription Factor AhR, Cytokines IL-6 and IL-22 in Subjects with and without Peri-Implantitis: A Case Control-Study.
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Autor/in / Beteiligte Person: | Martins, LRL ; Grzech-Leśniak, K ; Castro Dos Santos, N ; Suárez, LJ ; Giro, G ; Bastos, MF ; Shibli, JA |
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Zeitschrift: | International journal of environmental research and public health, Jg. 19 (2022-06-17), Heft 12 |
Veröffentlichung: | Basel : MDPI, c2004-, 2022 |
Medientyp: | academicJournal |
ISSN: | 1660-4601 (electronic) |
DOI: | 10.3390/ijerph19127434 |
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