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Purpose: To determine the risk of adverse outcomes among prefrail and frail individuals with and without cognitive impairment as well as those with isolated cognitive impairment compared to robust individuals without cognitive impairment.

Methods: Data from the Malaysian elders longitudinal research (MELoR) study were utilised. Baseline data were obtained from home-based computer-assisted interviews and hospital-based health-checks from 2013 to 2015. Protocol of MELoR study has been described in previous study (Lim in PLoS One 12(3):e0173466, 2017). Follow-up interviews were conducted in 2019 during which data on the adverse outcomes of falls, sarcopenia, hospitalization, and memory worsening were obtained. Sarcopenia at follow-up was determined using the strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire.

Results: Follow-up data was available for 776 participants, mean (SD) age 68.1 (7.1) years and 57.1% women. At baseline, 37.1% were robust, 12.8% had isolated cognitive impairment, 24.1% were prefrail, 1.0% were frail, 20.2% were prefrail with cognitive impairment, and 4.8% had CF. Differences in age, ethnicity, quality of life, psychological status, function and comorbidities were observed across groups. The association between CF with hospitalisation and falls compared to robust individuals was attenuated by ethnic differences. Pre-frail individuals were at increased risk of memory worsening compared robust individuals [aOR(95%CI) = 1.69 (1.09-2.60)]. Frail [7.70 (1.55-38.20)], prefrail with cognitive impairment [3.35 (1.76-6.39)] and CF [6.15 (2.35-16.11)] were significantly more likely to be sarcopenic at 5-year follow-up compared to the robust group.

Conclusions: Cognitive frailty was an independently predictor of sarcopenia at 5-year follow-up. The relationship between CF with falls and hospitalization, however, appeared to be accounted for by ethnic disparities. Future studies should seek to unravel the potential genetic and lifestyle variations between ethnic groups to identify potential interventions to reduce the adverse outcomes associated with CF.

Titel:	Cognitive frailty and 5-year adverse health-related outcomes for the Malaysian elders longitudinal research (MELoR) study.
Autor/in / Beteiligte Person:	Ong, JYQ ; Mat, S ; Kioh, SH ; Hasmuk, K ; Saedon, N ; Mahadzir, H ; Chin, AV ; Kamaruzzaman, SB ; Tan, MP
Link:	View record at Springer (Volltext)
Zeitschrift:	European geriatric medicine, Jg. 13 (2022-12-01), Heft 6, S. 1309-1316
Veröffentlichung:	2018- : Cham : Springer International Publishing ; <i>Original Publication</i>: Issy-les-Moulineaux, Paris : Elsevier Masson SAS, 2022
Medientyp:	academicJournal
ISSN:	1878-7649 (print)
DOI:	10.1007/s41999-022-00673-x
Schlagwort:	Aged Female Humans Male Cognition Frail Elderly Geriatric Assessment methods Quality of Life Middle Aged Frailty epidemiology Sarcopenia
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Eur Geriatr Med] 2022 Dec; Vol. 13 (6), pp. 1309-1316. <i>Date of Electronic Publication: </i>2022 Jul 09. MeSH Terms: Frailty* / epidemiology ; Sarcopenia* ; Aged ; Female ; Humans ; Male ; Cognition ; Frail Elderly ; Geriatric Assessment / methods ; Quality of Life ; Middle Aged References: Lim LM et al (2017) “Prevalence, risk factors and health outcomes associated with polypharmacy among urban community-dwelling older adults in multi-ethnic Malaysia.” PLoS ONE 12(3):e0173466. https://doi.org/10.1371/journal.pone.0173466 (in English). (PMID: 10.1371/journal.pone.0173466) ; Department of Statistics Malaysia (2016) “Population projections 2010-2040. Putrajaya, Malaysia.” [Online]. Available: https://www.dosm.gov.my/v1/index.php/index.php?r=column/ctheme&menu_id=L0pheU43NWJwRWVSZklWdzQ4TlhUUT09&bul_id=Y3kwU2tSNVFDOWp1YmtZYnhUeVBEdz09 . 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Contributed Indexing: Keywords: Accidental falls; Aged; Cognitive impairment; Frailty; Hospitalization; Sarcopenia Entry Date(s): Date Created: 20220709 Date Completed: 20221212 Latest Revision: 20230804 Update Code: 20240513

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Cognitive frailty and 5-year adverse health-related outcomes for the Malaysian elders longitudinal research (MELoR) study.