Persistent symptoms, quality of life, and risk factors in long COVID: a cross-sectional study of hospitalized patients in Brazil.

de Oliveira JF ; de Ávila RE ; et al.

In: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Jg. 122 (2022-09-01), S. 1044-1051

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Objectives: COVID-19 has been associated with long-term consequences to patient wellness and quality of life. Data on post-COVID-19 conditions are scarce in developing countries. This study aimed to investigate long COVID in a cohort of hospitalized patients in Brazil.

Methods: Surviving patients discharged from the hospital between July 1, 2020 and March 31, 2021 were assessed between 2 and 12 months after acute onset of COVID-19. The outcomes were the prevalence of persistent symptoms, risk factors associated with long COVID, and quality of life as assessed by the EuroQol 5D-3L questionnaire.

Results: Of 439 participants, most (84%) reported at least one long COVID symptom, at a median of 138 days (interquartile range [IQR] 90-201) after disease onset. Fatigue (63.1%), dyspnea (53.7%), arthralgia (56.1%), and depression/anxiety (55.1%) were the most prevalent symptoms. In multivariate analysis, dysgeusia (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.18-3.44, P <0.001) and intensive care unit (ICU) admission (OR 2.6, 95% CI 1.19-6.56, P = 0.03) were independently associated with long COVID. Fifty percent of patients reported a worsened clinical condition and quality of life.

Conclusion: Long-term outcomes of SARS-CoV-2 infection in a low- to middle-income country were relevant. Fatigue was the most common persistent symptom. ICU admission was an independent factor associated with long COVID. Dysgeusia could be a potential predictor of long COVID.

Titel:	Persistent symptoms, quality of life, and risk factors in long COVID: a cross-sectional study of hospitalized patients in Brazil.
Autor/in / Beteiligte Person:	de Oliveira JF ; de Ávila RE ; de Oliveira NR ; da Cunha Severino Sampaio N ; Botelho, M ; Gonçalves, FA ; Neto, CJF ; de Almeida Milagres AC ; Gomes, TCC ; Pereira, TL ; de Souza RP ; Molina, I
Link:	Full Text Finder (Volltext)
Zeitschrift:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Jg. 122 (2022-09-01), S. 1044-1051
Veröffentlichung:	Hamilton, ON : Elsevier ; <i>Original Publication</i>: Hamilton, ON : Decker, c1996-, 2022
Medientyp:	academicJournal
ISSN:	1878-3511 (electronic)
DOI:	10.1016/j.ijid.2022.07.063
Schlagwort:	Brazil epidemiology Cross-Sectional Studies Dysgeusia Fatigue epidemiology Fatigue etiology Humans Quality of Life Risk Factors SARS-CoV-2 Post-Acute COVID-19 Syndrome COVID-19 complications COVID-19 epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Infect Dis] 2022 Sep; Vol. 122, pp. 1044-1051. <i>Date of Electronic Publication: </i>2022 Jul 28. MeSH Terms: COVID-19* / complications ; COVID-19* / epidemiology ; Brazil / epidemiology ; Cross-Sectional Studies ; Dysgeusia ; Fatigue / epidemiology ; Fatigue / etiology ; Humans ; Quality of Life ; Risk Factors ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome References: Nat Med. 2021 Apr;27(4):626-631. (PMID: 33692530) ; Br J Anaesth. 2021 Mar;126(3):e110-e113. (PMID: 33413976) ; Thorax. 2021 Apr;76(4):396-398. (PMID: 33172844) ; Clin Microbiol Infect. 2021 Feb;27(2):258-263. (PMID: 33031948) ; Lancet. 2021 Jan 16;397(10270):220-232. (PMID: 33428867) ; PLoS One. 2020 Dec 11;15(12):e0243882. (PMID: 33306721) ; J Med Virol. 2022 Jan;94(1):253-262. (PMID: 34463956) ; JAMA Netw Open. 2021 May 3;4(5):e2111417. (PMID: 34037731) ; Clin Infect Dis. 2021 Aug 2;73(3):e826-e829. (PMID: 33624010) ; Front Med (Lausanne). 2021 May 04;8:653516. (PMID: 34017846) ; Nat Med. 2021 Apr;27(4):601-615. (PMID: 33753937) ; J Clin Med. 2021 Dec 16;10(24):. (PMID: 34945213) ; Eur Rev Med Pharmacol Sci. 2021 Jan;25(2):1114-1134. (PMID: 33577069) ; JAMA. 2020 Aug 11;324(6):603-605. (PMID: 32644129) ; Eur J Intern Med. 2022 Mar;97:36-41. (PMID: 34903448) ; EClinicalMedicine. 2021 May 24;36:100899. (PMID: 34036253) ; Clin Infect Dis. 2021 Jul 15;73(Suppl 1):S5-S16. (PMID: 33909072) ; ERJ Open Res. 2021 Feb 08;7(1):. (PMID: 33575312) ; Nat Med. 2020 Jul;26(7):1017-1032. (PMID: 32651579) ; ERJ Open Res. 2020 Oct 26;6(4):. (PMID: 33257910) ; Thorax. 2021 Apr;76(4):399-401. (PMID: 33273026) ; Emerg Infect Dis. 2022 Mar;28(3):730-733. (PMID: 35133956) ; Infection. 2021 Dec;49(6):1163-1186. (PMID: 34319569) Contributed Indexing: Keywords: Brazil; COVID-19; Dysgeusia; Long COVID; Quality of life; Risk factors Entry Date(s): Date Created: 20220731 Date Completed: 20220908 Latest Revision: 20230124 Update Code: 20240513 PubMed Central ID: PMC9330427

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