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The differences between Chinese herbal medicine (CHM)- and Western medicine (WM)-induced liver injury have rarely been reported. Our aim was to investigate the clinical features of patients with drug-induced liver injury (DILI) caused by CHM or WM. The medical records of 726 DILI patients were retrospectively collected at Peking University First Hospital from January 1995 through August 2019. The number of inpatients with DILI in our hospital showed an increasing trend over time. The incidence of DILI caused by CHM exhibited a linear trend toward an increase with time (P = .0012). Of the 726 DILI patients, females accounted for 65.8%. There were 353 cases (48.6%) caused by CHM and 225 cases (40.0%) caused by WM. The 3 most common causative CHMs were Polygonum multiflorum (38 cases), Fructus Psoraleae (35 cases), and Epimedium (26 cases). The proportions of female patients, alanine aminotransferase (ALT) levels, aspartate aminotransferase (AST) levels, total bilirubin (TBIL) levels and antinuclear antibody (ANA) positivity rates among cases caused by CHM were higher than those of cases caused by WM (P < .05). There were more patients with severe cases caused by CHM than with severe cases caused by WM (P < .05). The clinical characteristics of DILI caused by CHM differ from those caused by WM. The incidence of DILI caused by CHM is increasing yearly. The medication time of DILI caused by CHM is longer than that of DILI caused by WM, and the severity is greater. Therefore, it is necessary to scientifically and rationally use traditional CHM and monitor liver function. For DILI caused by CHM, the CHM prescription should be recorded in detail to provide detailed clinical data for scientific research on the liver toxicity of CHM.

Titel:	Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury.
Autor/in / Beteiligte Person:	Tan, K ; Yang, W ; Pang, L ; Hou, F
Link:	Full Text Finder (Volltext)
Zeitschrift:	Medicine, Jg. 101 (2022-08-12), Heft 32, S. e29909
Veröffentlichung:	Hagerstown, Md : Lippincott Williams & Wilkins, 2022
Medientyp:	academicJournal
ISSN:	1536-5964 (electronic)
DOI:	10.1097/MD.0000000000029909
Schlagwort:	Female Humans Retrospective Studies Chemical and Drug Induced Liver Injury drug therapy Chemical and Drug Induced Liver Injury epidemiology Chemical and Drug Induced Liver Injury etiology Chemical and Drug Induced Liver Injury, Chronic Drugs, Chinese Herbal adverse effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Medicine (Baltimore)] 2022 Aug 12; Vol. 101 (32), pp. e29909. MeSH Terms: Chemical and Drug Induced Liver Injury* / drug therapy ; Chemical and Drug Induced Liver Injury* / epidemiology ; Chemical and Drug Induced Liver Injury* / etiology ; Chemical and Drug Induced Liver Injury, Chronic* ; Drugs, Chinese Herbal* / adverse effects ; Female ; Humans ; Retrospective Studies References: Chalasani NP, Maddur H, Russo MW, et al. Reddy KR: ACG clinical guideline: diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2021;116:878–98. ; Reuben A, Koch DG, Lee WM. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010;52:2065–76. ; Bernal W, Auzinger G, Dhawan A, et al. Acute liver failure. Lancet. 2010;376:190–201. ; Suk KT, Kim DJ, Kim CH, et al. 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JAMA Dermatol. 2013;149:1025–32. Substance Nomenclature: 0 (Drugs, Chinese Herbal) Entry Date(s): Date Created: 20220812 Date Completed: 20220816 Latest Revision: 20230103 Update Code: 20240513 PubMed Central ID: PMC9371566

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Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury.